FlyBase Allele Report: Dmel\mir-958[KO]

General Information

Symbol

Dmel\mir-958^KO

Species

D. melanogaster

Name

FlyBase ID

FBal0301938

Feature type

allele

Associated gene

Dmel\mir-958

Associated Insertion(s)

TI{TI}mir-958^KO

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Chen et al., 2014)

Mutagen

ends-out gene targeting

(Chen et al., 2014)

FLPase

(Chen et al., 2014)

I-SceI

(Chen et al., 2014)

Progenitor genotype

Associated Insertion(s)

TI{TI}mir-958^KO

Cytology

Description

The mir-958 hairpin has been deleted. A w^+mW.hs marker which is flanked firstly by a pair of loxP sites and secondly (flanking the loxP sites) by a pair of inverted attP sites is present in place of the deleted sequence.

(Chen et al., 2014)

Allele components

Component

Use(s)

Also carries

attP

integrase target site

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female fertile

(Chen et al., 2014)

increased cell number | adult stage

(Mukherjee et al., 2021)

long lived | female (with Df(3L)BSC21)

(Chen et al., 2014)

male fertile

(Chen et al., 2014)

viable

(Chen et al., 2014)

Phenotype Manifest In

adult midgut epithelium

(Mukherjee et al., 2021)

intestinal stem cell | adult stage | increased number

(Mukherjee et al., 2021)

Detailed Description

Statement

Reference

mir-958^KO/Df(3L)BSC21 females show a significant increase in median lifespan compared to controls.

(Chen et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

mir-958^KO has increased cell number | adult stage phenotype, non-enhanceable by gbb^D20

(Mukherjee et al., 2021)

mir-958^KO has increased cell number | adult stage phenotype, non-enhanceable by gbb^D4

(Mukherjee et al., 2021)

Suppressed by

Statement

Reference

mir-958^KO has increased cell number | adult stage phenotype, suppressible by cbt^EP2237E1

(Mukherjee et al., 2021)

mir-958^KO has increased cell number | adult stage phenotype, suppressible by dpp^d12

(Mukherjee et al., 2021)

mir-958^KO has increased cell number | adult stage phenotype, suppressible by tkv^KK102319/Scer\GAL4^NP5130

(Mukherjee et al., 2021)

NOT suppressed by

Statement

Reference

mir-958^KO has increased cell number | adult stage phenotype, non-suppressible by gbb^D20

(Mukherjee et al., 2021)

mir-958^KO has increased cell number | adult stage phenotype, non-suppressible by gbb^D4

(Mukherjee et al., 2021)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

mir-958^KO has intestinal stem cell | adult stage | increased number phenotype, non-enhanceable by gbb^D20

(Mukherjee et al., 2021)

mir-958^KO has intestinal stem cell | adult stage | increased number phenotype, non-enhanceable by gbb^D4

(Mukherjee et al., 2021)

Suppressed by

Statement

Reference

mir-958^KO has intestinal stem cell | increased number | adult stage phenotype, suppressible by cbt^EP2237E1

(Mukherjee et al., 2021)

mir-958^KO has intestinal stem cell | increased number | adult stage phenotype, suppressible by dpp^d12

(Mukherjee et al., 2021)

mir-958^KO has adult midgut epithelium phenotype, suppressible by tkv^KK102319/Scer\GAL4^NP5130

(Mukherjee et al., 2021)

NOT suppressed by

Statement

Reference

mir-958^KO has intestinal stem cell | increased number | adult stage phenotype, non-suppressible by gbb^D20

(Mukherjee et al., 2021)

mir-958^KO has intestinal stem cell | increased number | adult stage phenotype, non-suppressible by gbb^D4

(Mukherjee et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

mir-958^KO is rescued by mir-958^+tCH322-67A5

(Mukherjee et al., 2021)

mir-958^KO is rescued by mir-958^1.4.H2A.GFP

(Mukherjee et al., 2021)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

58943

w^*; TI{TI}mir-958^KO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

miR-958^KO

(He et al., 2022)

mir-958^KO

(Mukherjee et al., 2021, Niu et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

Open Close