FB2026_02 , released June 18, 2026
Allele: Dmel\Snmp1T274Y.L439Y.UAS
Open Close
General Information
Symbol
Dmel\Snmp1T274Y.L439Y.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0321671
Feature type
allele
Associated gene
Dmel\Snmp1
Associated Insertion(s)
Carried in Construct
P{UAS-Snmp1.T274Y.L439Y}
Key Links
Transgenic product class
missense_variant
(Gomez-Diaz et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Gomez-Diaz et al., 2016)
Mutagen
in vitro construct
(Gomez-Diaz et al., 2016)
Progenitor genotype
Carried in construct
P{UAS-Snmp1.T274Y.L439Y}
Cytology
Description

UASt regulates expression of Snmp1 bearing T274Y and L439Y mutations within the internal 'tunnel' of the protein.

(Gomez-Diaz et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Snmp1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Snmp1T274Y.L439Y.UAS/Scer\GAL4Or67d.PF partially rescues Snmp11/Snmp12

      (Gomez-Diaz et al., 2016)

      Snmp1T274Y.L439Y.UAS/Scer\GAL4Or67d-GAL4-1 partially rescues Snmp11/Snmp12

      (Gomez-Diaz et al., 2016)
      Comments

      The impaired male pheromone (cis-vaccenyl acetate, cVA) detection characteristic for Snmp11/Snmp12 adult males is partially rescued by expression of Snmp1T274Y.L439Y.Scer\UAS under the control of Scer\GAL4Or67d.PF : the lack of Or67d neuronal activity (measured by extracellular recordings in individual sensilla) is significantly, albeit not fully, restored.

      The failure of adult flies transheterozygous for Snmp11/Snmp12 to detect the moth Heliothis virescens sex pheromone (Z)-11-hexadecenal when they are also ectopically expressing Hvir\HR13Scer\UAS.cKa under the control of two copies of Scer\GAL4Or67d-GAL4-1 can be partially restored by co-expression of Snmp1T274Y.L439Y.Scer\UAS : The Or67d neurons display significant activity (measured by extracellular recordings in individual sensilla) upon (Z)-11-hexadecenal presentation.

      (Gomez-Diaz et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Snmp1T274Y.L439Y.Scer\UAS
      Snmp1T274Y.L439Y.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)