FlyBase Allele Report: Dmel\Acly[HMC06049]

General Information

Symbol

Dmel\Acly^HMC06049

Species

D. melanogaster

Name

FlyBase ID

FBal0322318

Feature type

allele

Associated gene

Dmel\Acly

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC06049}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HMC06049}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMC06049

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | adult stage, with Scer\GAL4^Tk.PS

(Jugder et al., 2021)

female fertile, with Scer\GAL4^bam.PU

(François et al., 2023)

lethal - all die before end of larval stage, with Scer\GAL4^bam.PU

(François et al., 2023)

male fertile, with Scer\GAL4^NP1624

(François et al., 2023)

male sterile, with Scer\GAL4^bam.PU

(François et al., 2023)

Phenotype Manifest In

adult anterior midgut, with Scer\GAL4^Tk.PS

(Jugder et al., 2021)

adult enteroendocrine cell | decreased number, with Scer\GAL4^Tk.PS

(Jugder et al., 2021)

spermatozoon | absent, with Scer\GAL4^bam.PU

(François et al., 2023)

waste bag | absent, with Scer\GAL4^bam.PU

(François et al., 2023)

Detailed Description

Statement

Reference

The expression of ATPCL^HMC06049 under the control of Scer\GAL4^Tk.PS leads to fewer enteroendocrine cells and more lipid droplets in the adult anterior midgut

(Jugder et al., 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Acly^HMC06049 is rescued by Scer\GAL4^bam.PU/Acly^UASp.Tag:HA

(François et al., 2023)

Acly^HMC06049 is rescued by Acly^topi.Tag:HA

(François et al., 2023)

Not rescued by

Acly^HMC06049 is not rescued by Acly^{D1038A.UASp.Tag:HA}/Scer\GAL4^bam.PU

(François et al., 2023)

Acly^HMC06049 is not rescued by Scer\GAL4^bam.PU/Acly^{H772A.UASp.Tag:HA}

(François et al., 2023)

Acly^HMC06049 is not rescued by Acly^{R380A.UASp.Tag:HA}/Scer\GAL4^bam.PU

(François et al., 2023)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

65175

y¹ sc^* v¹ sev²¹; P{TRiP.HMC06049}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

ACLY^RNAi

(Jugder et al., 2021)

ATPCL^HMC06049

Acly^HMC06049

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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