FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\ash1AM5
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General Information
Symbol
Dmel\ash1AM5
Species
D. melanogaster
Name
FlyBase ID
FBal0338138
Feature type
allele
Associated gene
Dmel\ash1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(McCracken and Locke, 2016)
Mutagen
ethyl methanesulfonate
(McCracken and Locke, 2016)
Progenitor genotype
Cytology
Description

Amino acid replacement: H1882Y (revision of data in FBrf0233053).

(Locke, 2018.7.13)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:19,592,468..19,592,468 [-]
Nucleotide change:

C19592468T

Amino acid change:

H1882Y | ash1-PB; H1882Y | ash1-PC

Reported amino acid change:

H1882Y

Comment:

The mutation was originally reported as H1873W based on an outdated version of the ash1 annotation. The amino acid location of the mutation relative to the current annotation is 1882. A C to T nucleotide change in this codon leads to a H1882Y mutation.

(Locke, 2018.7.13)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ash1H1873W is a dominant enhancer of eye pigment variegation observed in the E1 (combination of gypsy{}ci-E1, P{lacW}Dplac) and Pci (P{lacW}Dplac) backgrounds; no eye pigmentation silencing is observed in a P{lacW}3-76a background.

      ash1H1873W is not a significant dominant suppressor of eye pigment variegation observed in the In(1)w[m4] background.

      The following transheterozygotes are lethal: ash1H1873W/Df(3L)Exel9007, ash1H1873W/ash1W790term, ash1H1873W/ash1Q893term, ash1H1873W/ash1N303mut and ash1H1873W/ash1W770mut.

      (McCracken and Locke, 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      P{lacW}Dplac, ash1AM5 has enhancer of variegation | dominant phenotype, enhanceable by trxAM1/trx[+]

      (McCracken and Locke, 2016)
      Enhancer of
      Statement
      Reference

      ash1AM5/ash1[+] is an enhancer of enhancer of variegation | dominant phenotype of P{lacW}Dplac, trxAM1

      (McCracken and Locke, 2016)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      ash1H1873W/+, trxS2582a/+ and ash1H1873W/+, trxR1578mut/+ double heterozygotes are viable, whereas ash1H1873W/+, trxS2582b/+ double heterozygotes are semi-viable, as compared to controls.

      ash1H1873W/+, trxR1578mut/+ double heterozygotes show a dominant enhancer of eye pigment variegation phenotype which is more severe than either single heterozygote.

      (McCracken and Locke, 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      4a5a
      (McCracken and Locke, 2016)
      ash1AM5
      ash1H1873W
      (McCracken and Locke, 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)