FB2026_02 , released June 18, 2026
Allele: Dmel\ash1AM2
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General Information
Symbol
Dmel\ash1AM2
Species
D. melanogaster
Name
FlyBase ID
FBal0338139
Feature type
allele
Associated gene
Dmel\ash1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(McCracken and Locke, 2016)
Mutagen
ethyl methanesulfonate
(McCracken and Locke, 2016)
Progenitor genotype
Cytology
Description

Deletion of nucleotides 2310-2334, resulting in a premature stop codon at amino acid residue W770.

(McCracken and Locke, 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:19,595,814..19,595,838 [-]
Comment:

A 25 bp deletion resulting in a stop codon at amino acid W779 (originally reported as W770 based on an outdated version of the ash1 annotation).

(Locke, 2018.7.13)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ash1W770mut is a dominant enhancer of eye pigment variegation observed in the E1 (combination of gypsy{}ci-E1, P{lacW}Dplac) and Pci (P{lacW}Dplac) backgrounds; no eye pigmentation silencing is observed in a P{lacW}3-76a background.

      ash1W770mut is a significant dominant suppressor of eye pigment variegation observed in the In(1)w[m4] background.

      The following transheterozygotes are lethal: ash1W770mut/Df(3L)Exel9007, ash1W770mut/ash1W790term, ash1W770mut/ash1Q893term, ash1W770mut/ash1N303mut and ash1W770mut/ash1H1873W.

      (McCracken and Locke, 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      ash1AM2, trx[+]/trxAM2 has viable phenotype

      (McCracken and Locke, 2016)

      ash1AM2, trxAM3/trx[+] has viable phenotype

      (McCracken and Locke, 2016)

      ash1AM2, trxAM1/trx[+] has viable phenotype

      (McCracken and Locke, 2016)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The following double heterozygotes are viable compared to controls: ash1W770mut/+, trxS2582a/+; ash1W770mut/+, trxR1578mut/+; and ash1W770mut/+, trxS2582b/+.

      (McCracken and Locke, 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      4a89a
      (McCracken and Locke, 2016)
      ash1AM2
      ash1W770*
      (McCracken and Locke, 2016)
      ash1W770mut
      Name Synonyms
      Secondary FlyBase IDs
        References (2)