FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\trxAM1
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General Information
Symbol
Dmel\trxAM1
Species
D. melanogaster
Name
FlyBase ID
FBal0338142
Feature type
allele
Associated gene
Dmel\trx
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(McCracken and Locke, 2016)
Progenitor genotype
Cytology
Description

Deletion of nucleotides 5578-5590. This results in a frameshift starting at amino acid residue 1578 and a premature stop codon (QQQQR to HGMLTstop).

(McCracken and Locke, 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:14,271,575..14,271,587 [-]
Comment:

A 13 bp deletion (reported a nucleotides 5578-5590) leads to a frameshift at amino acid 1578 of trx-PA and early translation termination after the addition of four novel amino acids.

(McCracken and Locke, 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      trxR1578mut homozygotes and trxR1578mut/trxS2582b transheterozygotes are lethal; trxR1578mut/trxS2582a transheterozygotes are near lethal.

      trxR1578mut is a dominant enhancer of eye pigment variegation observed in the E1 (combination of gypsy{}ci-E1, P{lacW}Dplac) and Pci (P{lacW}Dplac) backgrounds; in a P{lacW}3-76a background, however, only females show significant eye pigmentation silencing.

      trxS2582a is a male-only dominant suppressor of the eye pigment variegation observed in the In(1)wm4 background.

      (McCracken and Locke, 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      P{lacW}Dplac, trxAM1 has enhancer of variegation | dominant phenotype, enhanceable by ash1AM5/ash1[+]

      (McCracken and Locke, 2016)
      Enhancer of
      Statement
      Reference

      trxAM1/trx[+] is an enhancer of enhancer of variegation | dominant phenotype of P{lacW}Dplac, ash1AM5

      (McCracken and Locke, 2016)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The following double heterozygotes are semi-viable compared to controls: ash1W790term/+, trxR1578mut/+; ash1Q893term/+, trxR1578mut/+; and ash1N303mut/+, trxR1578mut/+. The following double heterozygotes are viable: ash1H1873W/+, trxR1578mut/+; and ash1W770mut/+, trxR1578mut/+.

      ash1H1873W/+, trxR1578mut/+ double heterozygotes show a dominant enhancer of eye pigment variegation phenotype which is more severe than either single heterozygote.

      (McCracken and Locke, 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      5b19a
      (McCracken and Locke, 2016)
      trxAM1
      trxR1578*
      (McCracken and Locke, 2016)
      trxR1578mut
      Name Synonyms
      Secondary FlyBase IDs
        References (2)