FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dscam1ΔL
Open Close
General Information
Symbol
Dmel\Dscam1ΔL
Species
D. melanogaster
Name
FlyBase ID
FBal0353149
Feature type
allele
Associated gene
Dmel\Dscam1
Associated Insertion(s)
TI{TI}Dscam1ΔL
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Zhang et al., 2019)
Mutagen
CRISPR/Cas9
(Zhang et al., 2019)
gene targeting by homologous recombination
(Zhang et al., 2019)
Progenitor genotype
Associated Insertion(s)
TI{TI}Dscam1ΔL
Cytology
Description

The genomic region encompassing the distal polyA site and most of the long 3' UTR of Dscam1 is replaced with a 1.8kb casette containing a Disc\RFPDsRed.3xP3.cUa marker flanked by loxP sites; the proximal polyadenylation site is retained.

(Zhang et al., 2019)
Allele components
Component
Use(s)
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2R:7,317,348..7,319,421 [-]
Comment:

2 kb of the long 3'UTR and and distal polyA site was deleted and replaced with a 1.8 kb RFP cassette. The deletion endpoints were determined from the deleted sequence provided to FlyBase by the author.

(Miura, 2019.11.15, Zhang et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Dscam1ΔL homozygous adults have a significant reduction in arborization of the PDF-positive ventral lateral neurons, compared to controls; there is also a low-penetrance phenotype of loss of the L-shaped structure of the adult mushroom body, compared to controls, this phenotype is seen at 100 percent penetrance when mutants also express Dscam1miRNA.UAS.18-20 under the control of Scer\GAL4elav.PU.

      (Zhang et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Dscam1ΔL
      (Zhang et al., 2023, Zhang et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)