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General Information
Symbol
Dmel\PRL-116
Species
D. melanogaster
Name
FlyBase ID
FBal0356149
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Inserted_sequence:

A

Comment:

The insertion of a single base (A on the coding strand) in the first coding exon of (PRL-1) causes a frameshift and leads to early translation termination.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Introduction of one base pair into the first exon of PRL-1, causing a frameshift and STOP codon in the following sequence and terminating translation after the 35th amino acid.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

PRL-116 mutants develop into morphologically normal adults. Upon treatment of flies with various stress stimuli, including ultraviolet, X-ray, cold, heat, starvation, CO[[2]], N[[2]] or ether, only high concentration of CO[[2]] treatment (5L/min CO[[2]] for 20s) causes a highly prevalent, non-reversible held-up wing phenotype; this phenotype is mostly induced at 3 days post eclosion onwards; spontaneous held-up wings are uncommon in the absence of CO[[2]] exposure; PRL-116 mutants with held-up wings have the same lifespan as controls; PRL-116 mutants exhibit the same avoidance to CO[[2]] as controls.

Examination of PRL-116 mutant indirect flight muscles by phalloidin staining and transmission electrical microscopy shows no obvious differences to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

PRL-116 has visible | adult stage | chemical conditional phenotype, suppressible by Scer\GAL4elav.PU/Gr21aHMS02850

PRL-116 has visible | adult stage | chemical conditional phenotype, suppressible | RU486 conditional | partially by Scer\GAL4elav.Switch.PO/uexUAS.cGa

PRL-116 has visible | adult stage | chemical conditional phenotype, suppressible by Scer\GAL4elav.PU/Hsap\PTP4A1UAS.cGa

PRL-116 has visible | adult stage | chemical conditional phenotype, suppressible by Scer\GAL4elav.PU/Hsap\PTP4A2UAS.cGa

Phenotype Manifest In
Suppressed by
Statement
Reference

PRL-116 has wing | chemical conditional phenotype, suppressible by Scer\GAL4elav.PU/Gr21aHMS02850

PRL-116 has wing | chemical conditional phenotype, suppressible | RU486 conditional | partially by Scer\GAL4elav.Switch.PO/uexUAS.cGa

PRL-116 has wing | chemical conditional phenotype, suppressible by Scer\GAL4elav.PU/Hsap\PTP4A1UAS.cGa

PRL-116 has wing | chemical conditional phenotype, suppressible by Scer\GAL4elav.PU/Hsap\PTP4A2UAS.cGa

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)