FlyBase Allele Report: Dmel\Efa6[12]

General Information

Symbol

Dmel\Efa6¹²

Species

D. melanogaster

Name

FlyBase ID

FBal0370560

Feature type

allele

Associated gene

Dmel\Efa6

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Bu et al., 2021)

Progenitor genotype

Cytology

Description

Deletion within Efa6; removes almost all of the coding region.

(Bu et al., 2021)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

3R:22,589,422..22,605,021 [+]

Inserted_sequence:

ATTGTCAAATGAGTGAGGGGT

Comment:

Most of the Efa6 coding region is removed and 21 nucleotides (ATTGTCAAATGAGTGAGGGGT) are inserted.

(Bu et al., 2021)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | P-stage (with Efa6^GX6w-)

(Bu et al., 2021)

abnormal neuroanatomy | P-stage | somatic clone

(Bu et al., 2021)

Phenotype Manifest In

dendrite | P-stage (with Efa6^GX6w-)

(Bu et al., 2021)

dendrite | P-stage | somatic clone

(Bu et al., 2021)

embryonic/larval sensory neuron | larval stage (with Efa6^GX6w-)

(Bu et al., 2021)

embryonic/larval sensory neuron | P-stage (with Efa6^GX6w-)

(Bu et al., 2021)

embryonic/larval sensory neuron | P-stage | somatic clone

(Bu et al., 2021)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Efa6^GX6w-/Efa6¹² has abnormal neuroanatomy | P-stage phenotype, enhanceable by Scer\GAL4^ppk.PU/stai^GL01099

(Bu et al., 2021)

NOT Enhanced by

Statement

Reference

Efa6^GX6w-/Efa6¹² has abnormal neuroanatomy | P-stage phenotype, non-enhanceable by CG17528⁶⁷/CG17528⁴¹

(Bu et al., 2021)

Suppressed by

Statement

Reference

Efa6^GX6w-/Efa6¹² has abnormal neuroanatomy | P-stage phenotype, suppressible | partially by gammaTub23C[+]/γTub23C^A15-2

(Bu et al., 2021)

NOT suppressed by

Statement

Reference

Efa6^GX6w-/Efa6¹² has abnormal neuroanatomy | P-stage phenotype, non-suppressible by CG17528⁶⁷/CG17528⁴¹

(Bu et al., 2021)

Enhancer of

Statement

Reference

Efa6^GX6w-/Efa6¹² is an enhancer of abnormal neuroanatomy | P-stage phenotype of Scer\GAL4^ppk.PU, stai^GL01099

(Bu et al., 2021)

Phenotype Manifest In

Enhanced by

Statement

Reference

Efa6^GX6w-/Efa6¹² has embryonic/larval sensory neuron | P-stage phenotype, enhanceable by Scer\GAL4^ppk.PU/stai^GL01099

(Bu et al., 2021)

Efa6^GX6w-/Efa6¹² has dendrite | P-stage phenotype, enhanceable by Scer\GAL4^ppk.PU/stai^GL01099

(Bu et al., 2021)

NOT Enhanced by

Statement

Reference

Efa6^GX6w-/Efa6¹² has embryonic/larval sensory neuron | P-stage phenotype, non-enhanceable by CG17528⁶⁷/CG17528⁴¹

(Bu et al., 2021)

Efa6^GX6w-/Efa6¹² has dendrite | P-stage phenotype, non-enhanceable by CG17528⁶⁷/CG17528⁴¹

(Bu et al., 2021)

Suppressed by

Statement

Reference

Efa6^GX6w-/Efa6¹² has embryonic/larval sensory neuron | P-stage phenotype, suppressible | partially by gammaTub23C[+]/γTub23C^A15-2

(Bu et al., 2021)

Efa6^GX6w-/Efa6¹² has dendrite | P-stage phenotype, suppressible | partially by gammaTub23C[+]/γTub23C^A15-2

(Bu et al., 2021)

NOT suppressed by

Statement

Reference

Efa6^GX6w-/Efa6¹² has embryonic/larval sensory neuron | P-stage phenotype, non-suppressible by CG17528⁶⁷/CG17528⁴¹

(Bu et al., 2021)

Efa6^GX6w-/Efa6¹² has dendrite | P-stage phenotype, non-suppressible by CG17528⁶⁷/CG17528⁴¹

(Bu et al., 2021)

Enhancer of

Statement

Reference

Efa6^GX6w-/Efa6¹² is an enhancer of embryonic/larval sensory neuron | P-stage phenotype of Scer\GAL4^ppk.PU, stai^GL01099

(Bu et al., 2021)

Efa6^GX6w-/Efa6¹² is an enhancer of dendrite | P-stage phenotype of Scer\GAL4^ppk.PU, stai^GL01099

(Bu et al., 2021)

Other

Statement

Reference

γTub23C^A15-2, Efa6^GX6w-/Efa6¹² has embryonic/larval sensory neuron | larval stage phenotype

(Bu et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Efa6^GX6w-/Efa6¹² is rescued by Scer\GAL4^ppk.PU/Efa6^ΔPH.UAS

(Bu et al., 2021)

Efa6^GX6w-/Efa6¹² is rescued by Scer\GAL4^ppk.PU/Efa6^{Nterm.UAS.Tag:CAAX(Unk)}

(Bu et al., 2021)

Efa6^GX6w-/Efa6¹² is rescued by Scer\GAL4^ppk.PU/Efa6^Nterm.UAS

(Bu et al., 2021)

Efa6^GX6w-/Efa6¹² is rescued by Efa6^UAS.FL/Scer\GAL4^ppk.PU

(Bu et al., 2021)

Efa6¹² is rescued by Efa6^UAS.FL/Scer\GAL4^ppk.PU

(Bu et al., 2021)

Not rescued by

Efa6^GX6w-/Efa6¹² is not rescued by Scer\GAL4^ppk.PU/Efa6^ΔMTED.UAS

(Bu et al., 2021)

Efa6^GX6w-/Efa6¹² is not rescued by Efa6^Cterm.UAS/Scer\GAL4^ppk.PU

(Bu et al., 2021)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Efa6¹²

efa6¹²

(Bu et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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