FlyBase Allele Report: Dmel\Ar1[10-1]

General Information

Symbol

Dmel\Ar1^10-1

Species

D. melanogaster

Name

FlyBase ID

FBal0375594

Feature type

allele

Associated gene

Dmel\Ar1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

loss of function allele

(Sano et al., 2022)

Mutagen

CRISPR/Cas9

(Sano et al., 2022)

Progenitor genotype

Cytology

Description

Causes a frameshift leading to a premature termination in all isoforms of the Akr1B protein. The mutant proteins lack most of the catalytic domain.

(Sano et al., 2022)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

3L:11,622,154..11,622,157 [-]

Comment:

ACCG is replaced with TTGTC for a net 1bp insertion at codon 30 of Akr1A-RA and Akr1D-RB (codon 64 of Akr1B-RB and Akr1b-RC), causing a frameshift and leading to early translation termination after the addition of eight novel amino acids.

Inserted_sequence:

TTGTC

(Sano, 2022.10.26)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Ar1^10-1, Ar2^10-1 has decreased body weight | larval stage | nutrition conditional phenotype, suppressible | partially by Mondo^UAS.ORF/Scer\GAL4^Cg.PA

(Sano et al., 2022)

Ar1^10-1, Ar2^10-1 has decreased body weight | larval stage | nutrition conditional phenotype, suppressible | partially by Mondo^UAS.ORF/Scer\GAL4^Act5C.PI

(Sano et al., 2022)

Other

Statement

Reference

Ar1^10-1, Ar2^10-1 has abnormal developmental rate | larval stage phenotype

(Sano et al., 2022)

Ar1^10-1, Ar2^10-1 has some die during larval stage phenotype

(Sano et al., 2022)

Ar1^10-1, Ar2^10-1 has lethal - all die before end of larval stage | nutrition conditional phenotype

(Sano et al., 2022)

Ar1^10-1, Ar2^10-1 has decreased body weight | larval stage | nutrition conditional phenotype

(Sano et al., 2022)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Akr1B^10-1

Ar1^10-1

CG6084^10-1

(Sano et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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