FlyBase Allele Report: Dmel\Dld[Δ]

General Information

Symbol

Dmel\Dld^Δ

Species

D. melanogaster

Name

FlyBase ID

FBal0407029

Feature type

allele

Associated gene

Dmel\Dld

Associated Insertion(s)

TI{TI}Dld^Δ

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Wu et al., 2025)

Mutagen

CRISPR/Cas9

(Wu et al., 2025)

Progenitor genotype

Associated Insertion(s)

TI{TI}Dld^Δ

Cytology

Description

Most of the coding region of endogenous Dld is replaced with a STOP-loxP-Disc\RFP^3xP3.cUa-loxP-STOP cassette.

(Wu et al., 2025)

Allele components

Component

Use(s)

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage | dominant

(Wu et al., 2025)

decreased rate of larval locomotory behavior | dominant

(Wu et al., 2025)

lethal - all die during embryonic stage | recessive

(Wu et al., 2025)

partially lethal | dominant

(Wu et al., 2025)

some die during larval stage | dominant

(Wu et al., 2025)

some die during P-stage | dominant

(Wu et al., 2025)

Phenotype Manifest In

adult brain

(Wu et al., 2025)

vacuole | adult stage | increased number

(Wu et al., 2025)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Dld^Δ has increased mortality during development | dominant phenotype, enhanceable by Scer\GAL4^elav.PLu/AMPKα^K57A.UAS

(Wu et al., 2025)

Dld^Δ has decreased rate of larval locomotory behavior | dominant phenotype, enhanceable by Scer\GAL4^elav.PLu/AMPKα^K57A.UAS

(Wu et al., 2025)

Dld^Δ has some die during P-stage | dominant phenotype, enhanceable by Scer\GAL4^elav.PLu/AMPKα^K57A.UAS

(Wu et al., 2025)

Dld^Δ has some die during larval stage | dominant phenotype, enhanceable by Scer\GAL4^elav.PLu/AMPKα^K57A.UAS

(Wu et al., 2025)

Suppressed by

Statement

Reference

Dld^Δ has increased mortality during development | dominant phenotype, suppressible | partially by Scer\GAL4^elav.PLu/AMPKα^UAS.mCherry

(Wu et al., 2025)

Dld^Δ has decreased rate of larval locomotory behavior | dominant phenotype, suppressible | partially by Scer\GAL4^elav.PLu/AMPKα^UAS.mCherry

(Wu et al., 2025)

Dld^Δ has some die during P-stage | dominant phenotype, suppressible | partially by Scer\GAL4^elav.PLu/AMPKα^UAS.mCherry

(Wu et al., 2025)

Dld^Δ has some die during larval stage | dominant phenotype, suppressible | partially by Scer\GAL4^elav.PLu/AMPKα^UAS.mCherry

(Wu et al., 2025)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Dld^Δ

dDLD^Δ

(Wu et al., 2025)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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