FlyBase Allele Report: Dmel\scrib[RNAi.UAS.cUa]

General Information

Symbol

Dmel\scrib^RNAi.UAS.cUa

Species

D. melanogaster

Name

FlyBase ID

FBal0407713

Feature type

allele

Associated gene

Dmel\scrib

Associated Insertion(s)

Carried in Construct

P{UAS-scrib.RNAi.U}

Also Known As

UAS-scrib-IR

Key Links

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-scrib.RNAi.U}

Cytology

Description

UAS regulatory sequences drive expression of an RNAi line that targets scrib.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

scrib

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of carcinoma

CEA

(Song et al., 2023, Xu et al., 2022)

model of cancer

CEA with Ras85D^V12.UAS

(Hodgson et al., 2021)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of carcinoma

is ameliorated by Glyat^TH00482

(Xu et al., 2022)

is ameliorated by Glyat^c02982

(Xu et al., 2022)

is ameliorated by Gadd45^HMS01436

(Xu et al., 2022)

is ameliorated by Gadd45^KK104250

(Xu et al., 2022)

is ameliorated by apt^UAS.cEa

(Song et al., 2023)

is exacerbated by apt^GD1367

(Song et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death | larval stage, with Scer\GAL4^ptc.PU

(Xu et al., 2025)

visible | adult stage, with Scer\GAL4^ptc.PU

(Xu et al., 2025)

Phenotype Manifest In

anterior crossvein | absent, with Scer\GAL4^ptc.PU

(Xu et al., 2025)

wing disc | larval stage, with Scer\GAL4^ptc.PU

(Xu et al., 2025)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^ptc.PU, scrib^RNAi.UAS.cUa has visible | adult stage phenotype, suppressible by Gp93^GS16347, Scer\GAL4^ptc.PU

(Xu et al., 2025)

Scer\GAL4^ptc.PU, scrib^RNAi.UAS.cUa has increased cell death | larval stage phenotype, suppressible by Gp93^GS16347, Scer\GAL4^ptc.PU

(Xu et al., 2025)

Other

Statement

Reference

Dcr-2^UAS.cDa, Scer\GAL4^en-e16E, scrib^RNAi.UAS.cUa has visible phenotype

(Liang et al., 2014)

Dcr-2^UAS.cDa, Scer\GAL4^en-e16E, scrib^RNAi.UAS.cUa has abnormal size phenotype

(Liang et al., 2014)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^ptc.PU, scrib^RNAi.UAS.cUa has anterior crossvein | absent phenotype, suppressible by Gp93^GS16347, Scer\GAL4^ptc.PU

(Xu et al., 2025)

Scer\GAL4^ptc.PU, scrib^RNAi.UAS.cUa has wing disc | larval stage phenotype, suppressible by Gp93^GS16347, Scer\GAL4^ptc.PU

(Xu et al., 2025)

Other

Statement

Reference

Dcr-2^UAS.cDa, Scer\GAL4^en-e16E, scrib^RNAi.UAS.cUa has wing phenotype

(Liang et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

scrib^RNAi.UAS.cUa

scrib^VDRC.cUa

scrib^{dsRNA.UAS.cUa}

Name Synonyms

Secondary FlyBase IDs

FBal0362651
FBal0296167

References (9)

Report Sections

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