FlyBase Allele Report: Dmel\POLDIP2[del]

General Information

Symbol

Dmel\POLDIP2^del

Species

D. melanogaster

Name

FlyBase ID

FBal0407878

Feature type

allele

Associated gene

Dmel\POLDIP2

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Chen et al., 2025)

Mutagen

CRISPR/Cas9

(Chen et al., 2025)

Progenitor genotype

Cytology

Description

Deletion that removes most of the POLDIP2 coding region.

(Chen et al., 2025)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | spermatogenesis

(Chen et al., 2025)

male semi-sterile | progressive

(Chen et al., 2025)

Phenotype Manifest In

mitochondrial derivative

(Chen et al., 2025)

mitochondrial nucleoid | spermatogenesis

(Chen et al., 2025)

nuclear chromosome | spermatogenesis

(Chen et al., 2025)

seminal vesicle

(Chen et al., 2025)

spermatid

(Chen et al., 2025)

spermatozoon | decreased number

(Chen et al., 2025)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

POLDIP2^del has male semi-sterile | progressive phenotype, suppressible by Hsap\POLDIP2^POLDIP2.PC

(Chen et al., 2025)

POLDIP2^del has male semi-sterile | progressive phenotype, suppressible by Ecol\ExoIII^POLDIP2-mito

(Chen et al., 2025)

Other

Statement

Reference

EndoG^MB07150/EndoG^KO, POLDIP2^del has sterile phenotype

(Chen et al., 2025)

Phenotype Manifest In

Suppressed by

Statement

Reference

POLDIP2^del has mitochondrial nucleoid | spermatogenesis phenotype, suppressible by Ecol\ExoIII^POLDIP2-mito

(Chen et al., 2025)

POLDIP2^del has spermatozoon phenotype, suppressible by Ecol\ExoIII^POLDIP2-mito

(Chen et al., 2025)

Other

Statement

Reference

Atg7^HMS01358, POLDIP2^del, Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG has mitochondrial chromosome | parental effect | embryonic stage phenotype

(Chen et al., 2025)

EndoG^MB07150/EndoG^KO, POLDIP2^del has spermatid phenotype

(Chen et al., 2025)

EndoG^MB07150/EndoG^KO, POLDIP2^del has cystic bulge phenotype

(Chen et al., 2025)

EndoG^MB07150/EndoG^KO, POLDIP2^del has investment cone phenotype

(Chen et al., 2025)

EndoG^MB07150/EndoG^KO, POLDIP2^del has mitochondrial nucleoid | spermatogenesis phenotype

(Chen et al., 2025)

EndoG^MB07150/EndoG^KO, POLDIP2^del has nuclear chromosome | spermatogenesis phenotype

(Chen et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

POLDIP2^del is rescued by POLDIP2^+tCa

(Chen et al., 2025)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

POLDIP2^del

poldip2^del

(Chen et al., 2025)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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