Gene Group: G PROTEIN COUPLED RECEPTORS

General Information

Name

G PROTEIN COUPLED RECEPTORS

Species

D. melanogaster

Symbol

GPCR

FlyBase ID

FBgg0000172

Date last reviewed

2023-06-30

Number of members

117

Description

G protein coupled receptors (GPCRs) are seven-transmembrane spanning receptors that couple extracellular signaling events to intracellular effector molecules. GPCRs signal via heterotrimeric G proteins (Gα.Gβγ) associated on the inner leaflet of the plasma membrane. Agonist-binding by the GPCR promotes the release of Gα from Gβγ which targets downstream effectors such as adenylate cyclases, ion channels and phospholipases. (Adapted from PMID:15747061).

Notes on Group

Source Material

The G PROTEIN COUPLED RECEPTORS Gene Group has been compiled using the following publication(s): Fujinaga et al., 2025, Vieira Contreras et al., 2024, Scholz et al., 2023, Schlichting et al., 2022, Qi et al., 2017, de Mendoza et al., 2016, Xia et al., 2016, Hanlon and Andrew, 2015, Hilbrant et al., 2014, Agrawal et al., 2013, Araújo et al., 2013, Bayliss et al., 2013, Collin et al., 2013, Gasque et al., 2013, Li et al., 2013, Vogel et al., 2013, Caers et al., 2012, Ohhara et al., 2012, Patel et al., 2012, Posnien et al., 2012, Hansen et al., 2011, Ida et al., 2011, Veenstra, 2009, Yapici et al., 2008, Dolezelova et al., 2007, Garczynski et al., 2006, Hauser et al., 2006, Hauser et al., 2006, Hummel and Klämbt, 2006, Jorgensen et al., 2006, Cazzamali et al., 2005, Evans and Maqueira, 2005, Sudo et al., 2005, Huang and Klein, 2004, Mitri et al., 2004, Park et al., 2003, Harmar, 2001, Mezler et al., 2001, Brody and Cravchik, 2000, and Josefsson, 1999 .

Key Gene Ontology (GO) terms

Molecular Function

G protein-coupled receptor activity

Biological Process

G protein-coupled receptor signaling pathway

Cellular Component

plasma membrane

Related Gene Groups

Parent group(s)

TRANSMEMBRANE RECEPTORS

Component group(s)

CLASS A GPCRs