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FB2026_01
,
released March 12, 2026
fs(1)107, l(1)6P6, fs(1)A107
glycosyltransferase - directs glycosphingolipid biosynthesis - functions in oogenesis and EGF-R signaling - helps maintain epithelial structures - controls the extracellular gradient of the EGFR ligand Gurken
Please see the JBrowse view of Dmel\brn for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.52
Gene model reviewed during 5.55
1.3 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
325 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\brn using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Northern analysis shows that brn is expressed in ovaries, in adult males and females, and throughout embryogenesis. In situ analysis of oogenesis shows that the expression of brn begins in germ cells in germarium region 2a, at the time when follicle cells first surround the nurse cell-oocyte complex. brn expression continues uniformly until oocyte stage S10A, when transcript levels in oocytes and nurse cells increase sharply.
JBrowse - Visual display of RNA-Seq signals
View Dmel\brn in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Phenotypic analysis proposes that brn and egh, originating from the germline, collaborate with N on the apical surface of follicle cells to mediate germline-follicle cell adhesion. Wild type function of egh and brn is required for the formation of the follicular epithelium and maintenance of the apical-basal polarity, to inhibit follicle cell division, induction of dorsal follicle cell fates (but not specification of polar/stalk cell fates) and for concerted border cell-main body epithelium migration.
brn has a role in chorion formation and neurogenesis. Double mutant phenotypes with Egfr alleles suggest brn is required for dorsoventral patterning of the ovarian follicle. Mosaic experiments show that whereas the Egfr product is required in the follicle cells, the brn product is required in the germline. The brn/Egfr interaction is required for migration of prefollicular cells between each oocyte/nurse cell complex and for establishing continuous follicular epithelium around each oocyte/nurse cell complex. brn may be part of a germline signalling pathway differentially regulating successive Egfr-dependent follicle cell activities.
brn is a neurogenic locus, mutants show characteristic neural hyperplasia. Eggshells have fused dorsal appendages suggesting that the chorion has been ventralised.
Source for identity of: brn CG4934
