Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
135, 119 (aa); 12 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\janA using the Feature Mapper tool.
Comment: reported as dorsal/lateral sensory complexes
GBrowse - Visual display of RNA-Seq signalsView Dmel\janA in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Expression is enriched in embryonic gonads.
The molecular organization of the 'rp49-Sry-jan' gene cluster, including gene order, direction of transcription and partial overlap of the janA and janB genes is strictly conserved between D.melanogaster and D.pseudoobscura.pseudoobscura. In D.melanogaster the translation initiation codons of the divergently transcribed Sry-β and janA are separated by only 378bp, whereas the corresponding distance is only 176bp in D.pseudoobscura.pseudoobscura. Promoter analysis reveals that despite the physical proximity of the two genes, their transcription is regulated by separate cis-acting sequences.
Analysis of the expression of a number of janB-Ecol\lacZ constructs shows that the testis-specific expression of janB is mediated by a short DNA sequence (from -174 to +107bp) that is located entirely within the last exon of the upstream, partially overlapping, janA gene. The presence in cis of an active janA gene leads to a reduced accumulation of janB-Ecol\lacZ hybrid RNA, supporting the hypothesis that janA transcription interferes with the function of the janB cis-regulatory elements.
One of two partially overlapping genes, janA and janB, regulate the expression of somatic sex differentiation. janA is expressed in a complex way in both males and females; janB is only expressed in males (Yanicostas, Vincent and Lepesant, 1989).