FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\toc
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General Information
Symbol
Dmel\toc
Species
D. melanogaster
Name
toucan
Annotation Symbol
CG9660
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015600
Gene Model Status
Current
Stock Availability
63 publicly available
Gene Summary
toucan (toc) encodes a protein that associates with spindle microtubules being involved in mitotic spindle organization, mitotic sister chromatid segregation and ovarian follicle cell formation. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
23D1-23D2
Sequence location
Recombination map
2-8
RefSeq locus
NT_033779 REGION:3068345..3144786
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables microtubule binding
inferred from biological aspect of ancestor with PANTHER:PTN001271408
(GO Reference Genome Project, 2011-)
Biological Process (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in syncytial blastoderm mitotic cell cycle
inferred from mutant phenotype
(Mirouse et al., 2005, Debec et al., 2001)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (8 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
located_in cell cortex
inferred from direct assay
(Grammont et al., 2000)
located_in centrosome
inferred from direct assay
(Debec et al., 2001)
located_in midbody
inferred from direct assay
(Debec et al., 2001)
located_in nuclear membrane
inferred from direct assay
(Debec et al., 2001)
located_in nucleus
inferred from direct assay
(Grammont et al., 2000)
located_in spindle pole
inferred from direct assay
(Debec et al., 2001)
located_in spindle
inferred from direct assay
(Debec et al., 2001)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
colocalizes_with cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN001271408
(GO Reference Genome Project, 2011-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001271408
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
toucan (toc) encodes a protein that associates with spindle microtubules being involved in mitotic spindle organization, mitotic sister chromatid segregation and ovarian follicle cell formation. [Date last reviewed: 2019-03-14]
Gene Model and Products
Number of Transcripts
10
Number of Unique Polypeptides
10

Please see the JBrowse view of Dmel\toc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VQM0)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Stop-codon suppression (UGA) postulated; FBrf0216884.

Gene model reviewed during 5.44

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
toc-RA
FBtr0077662
NM_057805
8297
2162
toc-RB
FBtr0077665
NM_164526
4854
993
toc-RC
FBtr0077664
NM_164525
3121
888
toc-RD
FBtr0077663
NM_164524
3410
984
toc-RE
FBtr0110903
NM_001042864
4787
945
toc-RF
FBtr0112883
NM_001103594
2525
682
toc-RG
FBtr0329906
NM_001273058
4265
840
toc-RH
FBtr0329907
NM_001273059
4787
993
toc-RI
FBtr0335388
NM_001273060
3266
936
toc-RJ
FBtr0335389
NM_001273061
4628
892
Additional Transcript Data and Comments
Reported size (kB)

8, 7 (northern blot)

(Grammont et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
toc-PA
FBpp0077346
234.1
2162
9.06
Q9VQM0
NP_477153
AAF51145
toc-PB
FBpp0077349
109.9
993
7.13
Q9VQL8
NP_722877
AAF51147
toc-PC
FBpp0077348
98.5
888
6.90
Q8IPZ1
NP_722876
AAN10408
toc-PD
FBpp0077347
108.2
984
7.96
Q8IPZ2
NP_722875
AAN10407
toc-PE
FBpp0110203
104.6
945
7.89
Q0E8U3
NP_001036329
ABI31284
toc-PF
FBpp0111796
76.6
682
5.65
A8DYU0
NP_001097064
ABV53609
toc-PG
FBpp0302940
93.2
840
5.16
M9PBW7
NP_001259987
AGB92524
toc-PH
FBpp0302941
110.0
993
6.05
M9PCH2
NP_001259988
AGB92525
toc-PI
FBpp0307372
103.1
936
7.07
M9PC13
NP_001259989
AGB92526
toc-PJ
FBpp0307373
99.3
892
7.05
M9PED5
NP_001259990
AGB92527
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

2176 (aa); 235 (kD predicted)

(Grammont et al., 1997)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\toc using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.15

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4
organism | ubiquitous
(Grammont et al., 1997)
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
central brain anlage in statu nascendi
(Fisher et al., 2012)
dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
foregut anlage in statu nascendi
(Fisher et al., 2012)
hindgut anlage in statu nascendi
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
amnioserosa anlage
(Fisher et al., 2012)
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic head sensory system
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
embryonic optic lobe primordium
(Fisher et al., 2012)
adult stageoogenesis stage S3 -- S8
oocyte | posterior
(Grammont et al., 1997)
oogenesis stage S7
follicle cell | posterior
(Grammont et al., 1997)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
(Grammont et al., 1997)
Additional Descriptive Data

Seven and 8 kb transcripts were detected in Northern blots of adults.

(Grammont et al., 1997)

toc transcript is detected in the germarium as soon as the 16-cell cysts are formed, and through stages S1-S2 of oogenesis. In stages S10A-S10B expression is detected in the nurse cell and in the posterior of the oocyte. Expression is uniform in the late stage oocyte and the early embryo. The expression pattern detected in a EcollacZ enhancer trap (EcollacZtoc-P) is consistent with toc transcript expression.

(Grammont et al., 1997)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic cycle 2 -- embryonic cycle 13
organism
• nucleus

Comment: absent by cycle 14

(Debec et al., 2001)
organism

Comment: telophase

(Debec et al., 2001)
organism

Comment: interphase

(Debec et al., 2001)
organism
• spindle

Comment: prophase and metaphase

(Debec et al., 2001)
organism

Comment: anaphase

(Debec et al., 2001)
organism
• midbody

Comment: telophase

(Debec et al., 2001)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 2
organism
(Debec et al., 2001)
Additional Descriptive Data

toc protein is visible during all syncytial divisions in the embryo. Protein levels decrease during the 13th division,and are undetectable by embryonic cycle 14. Localization of toc protein is dynamic during the mitotic cycle. During interphase, toc localizes to the centrosomes and nuclear envelope. During prophase, toc protein is associated with the two half-spindles. At metaphase, toc is associated with the entire spindle. During anaphase, toc protein accumulates at the spindle poles, under the centrosomes. During telophase, toc protein accumulates at the midbody and in the centrosome area.

(Debec et al., 2001)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cell cortex
inferred from direct assay
(Grammont et al., 2000)
located_in centrosome
inferred from direct assay
(Debec et al., 2001)
located_in midbody
inferred from direct assay
(Debec et al., 2001)
located_in nuclear membrane
inferred from direct assay
(Debec et al., 2001)
located_in nucleus
inferred from direct assay
(Grammont et al., 2000)
located_in spindle pole
inferred from direct assay
(Debec et al., 2001)
located_in spindle
inferred from direct assay
(Debec et al., 2001)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\toc in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 42 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of toc
Transgenic constructs containing regulatory region of toc
Aberrations (Deficiencies and Duplications) ( 29 )
Inferred from experimentation ( 29 )
Gene disrupted in
Df(2L)16X42
(Grammont et al., 1997)
Df(2L)17
(Ferro, 2002.12)
Df(2L)18
(Ferro, 2002.12)
Df(2L)AS2
(Ferro, 2002.12)
Df(2L)AS4
(Ferro, 2002.12)
Df(2L)AS9
(Ferro, 2002.12)
Df(2L)BSC162
(Christensen and Cook, 2006.8.29)
Df(2L)BSC163
(Christensen and Cook, 2006.8.29)
Df(2L)BSC164
(Christensen and Cook, 2006.8.29)
Df(2L)BSC232
(Christensen and Cook, 2007.3.22)
Df(2L)BSC238
(Christensen and Cook, 2006.12.5)
Df(2L)Exel7015
(Ryder, 2004.4.26)
Df(2L)JS7
(Su et al., 2001, Eeken, 2000.2.29)
Df(2L)JS17
(Ferro, 2002.12, Su et al., 2001, Eeken, 2000.2.29, Spradling et al., 1999, BDGP Project Members, 1994-1999)
Df(2L)JS25
(Ferro, 2002.12)
Df(2L)JS27
(Ferro, 2002.12)
Df(2L)JS31
(Grammont et al., 1997)
Df(2L)S2590
(Laverty, 1998.12.3)
In(2LR)DTD16LDTD42R
(Su et al., 2001, Spradling et al., 1999, BDGP Project Members, 1994-1999)
Ts(2Rt;3Lt)DTD62+Ts(2Lt;3Rt)HVD7
(Su et al., 2001)
Gene not disrupted in
Df(2L)16
(Ferro, 2002.12)
Df(2L)19
(Ferro, 2002.12)
Df(2L)20
(Ferro, 2002.12)
Df(2L)30A-C
(BDGP Project Members, 1994-1999)
Df(2L)AS8
(Ferro, 2002.12)
Df(2L)C28
(Ferro, 2002.12, Su et al., 2001, Eeken, 2000.2.29)
Df(2L)C144
(Su et al., 2001, Spradling et al., 1999, BDGP Project Members, 1994-1999)
Df(2L)DTD52-D51
(Su et al., 2001)
Df(2L)S2590
(BDGP Project Members, 1994-1999)
Gene partially disrupted in
Df(2L)C28
(Wisotzkey et al., 2003)
Df(2L)CRIMIC-CR71046
(Gene Disruption Project members, 2018-)
Inferred from location ( 10 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | maternal effect
lethal | recessive
lethal - all die during embryonic stage | maternal effect, with Scer\GAL4VP16.mat.αTub67C
lethal - all die during embryonic stage | maternal effect, with Scer\GAL4VP16.mat.αTub67C, tocP
lethal - all die during embryonic stage | maternal effect, with Scer\GAL4VP16.mat.αTub67C, tocPR3
lethal - all die during embryonic stage | maternal effect, with Scer\GAL4VP16.mat.αTub67C, tocRNAi.UASp
partially lethal
viable
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile | recessive
fertile
Other Phenotypes
Allele
abnormal mitotic cell cycle | embryonic stage | maternal effect
abnormal mitotic cell cycle | embryonic stage | maternal effect, with Scer\GAL4VP16.mat.αTub67C
some die during embryonic stage | maternal effect, with Scer\GAL4VP16.mat.αTub67C
some die during embryonic stage | maternal effect, with Scer\GAL4VP16.mat.αTub67C, tocP
some die during embryonic stage | maternal effect, with Scer\GAL4VP16.mat.αTub67C, tocPR3
some die during embryonic stage | maternal effect, with Scer\GAL4VP16.mat.αTub67C, tocRNAi.UASp
Phenotype manifest in
Allele
dorsal appendage
dorsal appendage | germline clone
egg
egg chamber
fertilized egg | germline clone
follicle cell
germarium
kinetochore microtubule, with Scer\GAL4VP16.mat.αTub67C
nuclear chromosome, with Scer\GAL4VP16.mat.αTub67C
spindle
spindle, with Scer\GAL4VP16.mat.αTub67C
spindle microtubule, with Scer\GAL4VP16.mat.αTub67C
spindle pole
spindle pole, with Scer\GAL4VP16.mat.αTub67C
stalk follicle cell
stretch follicle cell
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (6)
Hsap\MTUS1
3 of 14
Yes
Yes
Hsap\MTUS2
3 of 14
Yes
Yes
Hsap\CCDC69
2 of 14
No
Yes
Hsap\CGNL1
1 of 14
No
Yes
Hsap\CTTNBP2
1 of 14
No
No
Hsap\MNS1
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (5)
Rnor\Mtus1
3 of 14
Yes
Yes
Rnor\Mtus2
3 of 14
Yes
Yes
Rnor\Ccdc69
1 of 14
No
Yes
Rnor\Lamc1
1 of 14
No
No
Rnor\Mns1
1 of 14
No
No
Mus musculus (laboratory mouse) (5)
Mmus\Mtus2
5 of 14
Yes
Yes
Mmus\Mtus1
3 of 14
No
Yes
Mmus\Ccdc69
1 of 14
No
Yes
Mmus\Cgnl1
1 of 14
No
Yes
Mmus\Mns1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (5)
Xtro\asb7
1 of 13
Yes
Yes
Xtro\mns1
1 of 13
Yes
No
Xtro\mtus1
1 of 13
Yes
Yes
Xtro\septin5
1 of 13
Yes
No
Xtro\srbd1
1 of 13
Yes
No
Danio rerio (Zebrafish) (11)
Drer\mtus1a
3 of 14
Yes
Yes
Drer\mtus1b
3 of 14
Yes
Yes
Drer\mtus2a
3 of 14
Yes
Yes
Drer\ccdc69
1 of 14
No
Yes
Drer\LOC110437717
1 of 14
No
Yes
Drer\mns1
1 of 14
No
No
Drer\si:busm1-105l16.2
1 of 14
No
Yes
Drer\si:ch211-51a19.5
1 of 14
No
Yes
Drer\si:dkey-88n24.5
1 of 14
No
Yes
Drer\si:dkey-103d23.3
1 of 14
No
Yes
Drer\zgc:174719
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\ttr-14
1 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (3)
Agam\AgaP_AGAP008556
3 of 12
Yes
Yes
Agam\AgaP_AGAP008554
2 of 12
No
Yes
Agam\AgaP_AGAP004208
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:toc. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    MTUS1; microtubule associated scaffold protein 1
    3 of 14
    609589
        MTUS2; microtubule associated scaffold protein 2
        3 of 14
        619358
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Interaction Browsers
            Summary of Genetic Interactions
            Interaction Browsers
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            External Data
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyBase
            External Links
            External Data
            Linkouts
            Class of Gene
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2L
            Recombination map
            2-8
            Cytogenetic map
            23D1-23D2
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            23D1-23D2
            Limits computationally determined from genome sequence between P{PZ}lilli00632 and P{PZ}toc01361
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            23D-23D
            (Couderc, 1997.7.4, Grammont et al., 1996)
            23D1-23D2
            (determined by in situ hybridisation)
            (Spradling et al., 1999)
            23D-23D
            (determined by in situ hybridisation)
            (Grammont et al., 1997)
            23D1-23D2
            (BDGP Project Members, 1994-1999)
            Experimentally Determined Recombination Data
            Location

            2-8

            (FlyBase, 2016)

            2-7.0

            (Comeron et al., 2012)

            2-

            (Grammont et al., 1996, Lemaitre et al., 1993)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (63)
            Genomic Clones (71)
            cDNA Clones (49)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            Antibody Information
            Laboratory Generated Antibodies
             

            polyclonal

            (Debec et al., 2001)
            Commercially Available Antibodies
             
            Cell Line Information
            Publicly Available Cell Lines
             
              Other Stable Cell Lines
               
                Other Comments

                Candidate stable intronic sequence RNA (sisRNA) identified within 5'UTR of this gene.

                (Pek et al., 2015)

                toc is essential for the assembly and function of the syncytial mitotic spindles.

                (Debec et al., 2001)

                Dominant interactions indicate that toc is acting in the same signalling pathways for the formation of the egg chamber as da, N and Dl.

                (Grammont et al., 1997)

                toc is expressed and required in germline cells to promote proper differentiation of the somatic follicle cells. Results propose toc participates in the production or localisation of a germline-specific signal(s) that is required for the patterning of the follicular epithelium.

                (Grammont et al., 1997)

                Mutant ovaries are defective in the enclosure of newly formed germline cysts by the follicle cells, the formation of interfollicular stalks, the migration of follicle cells over the oocyte and the formation of the eggshell. Overexpression of toc causes the production of longer interfollicular stalks.

                (Grammont et al., 1997)

                Identified via an enhancer-trap line showing maternal effect female sterility.

                (Grammont et al., 1996)

                Analysis of revertant alleles of tocP suggest toc is required for communciation between germline cells and somatic cells during oogenesis.

                (Grammont et al., 1996)
                Relationship to Other Genes
                Source for database merge of

                Source for merge of: toc BcDNA:LD27161

                (FlyBase, 1996-)
                Additional comments

                Source for merge of toc BcDNA:LD27161 was a shared cDNA ( date:020730 ).

                (FlyBase, 1996-)
                Nomenclature History
                Source for database identify of
                Nomenclature comments
                Etymology
                Synonyms and Secondary IDs (12)
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                Study result (0)
                Result
                Result Type
                Title
                External Crossreferences and Linkouts ( 97 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                FlyMine - An integrated database for Drosophila genomics
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                MIST (protein-protein) - An integrated Molecular Interaction Database
                References (91)