FlyBase Gene Report: Dmel\lbm

General Information

Symbol

Dmel\lbm

Species

D. melanogaster

Name

late bloomer

Annotation Symbol

CG2374

Feature Type

protein_coding_gene

FlyBase ID

FBgn0016032

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

Facilitates synapse formation. (UniProt, Q24188)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

lbl

Key Links

Genomic Location

Cytogenetic map

42E6-42E6

Sequence location

2R:7,049,238..7,051,964 [+]

Recombination map

2-55

RefSeq locus

NT_033778 REGION:7049238..7051964

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in synapse assembly

inferred from mutant phenotype

(Kopczynski et al., 1996)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in extracellular region

inferred from direct assay

(Kopczynski et al., 1996)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

located_in extracellular region

inferred from sequence or structural similarity

(Kopczynski et al., 1996)

located_in membrane

inferred from electronic annotation with InterPro:IPR008952, InterPro:IPR018499

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity

(Todres et al., 2000)

inferred from sequence model

(Fradkin et al., 2002)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001060286

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

TETRASPANINS

Protein Family (UniProt)

Belongs to the tetraspanin (TM4SF) family. (Q24188)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

TETRASPANINS -: Tetraspanins (TSP) have four transmembrane domains and two extracellular loops containing specific short motifs, including highly conserved cysteine residues. TSPs are thought to function as scaffolds that bring multiple proteins - including other TSPs, membrane-associated proteins, extracellular and cytosolic proteins - into single membrane region. These regions are called tetraspanin-enriched microdomains. (Adapted from FBrf0227776 and FBrf0152316).

Protein Function (UniProtKB)

Facilitates synapse formation.

(UniProt, Q24188)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\lbm for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q24188)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.48

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

lbm-RA

FBtr0089033

NM_078915

1029

208

lbm-RB

FBtr0336873

NM_001273828

923

208

Additional Transcript Data and Comments

Reported size (kB)

1.0 (longest cDNA)

(Kopczynski et al., 1996)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

lbm-PA

FBpp0088104

23.0

208

4.62

FBpp0307822

23.0

208

4.62

Q24188

NP_001260757

AGB93290

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

208 aa isoforms: lbm-PA, lbm-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

208 (aa)

(Kopczynski et al., 1996)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\lbm using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

lbm_1
lbm_2

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.13

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 14

RP neuron

(Kopczynski et al., 1996)

larval VUM neuron

(Kopczynski et al., 1996)

U neuron

(Kopczynski et al., 1996)

larval DA1 motor neuron

(Kopczynski et al., 1996)

Additional Descriptive Data

lbm is expressed specifically by motor neurons, such as aCC, RP1-RP5, the three U neurons, and the VUM neurons. It is also expressed transiently and at lower levels in some peripheral sensory neurons.

(Kopczynski et al., 1996)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16

motor neuron

• axon

(Kopczynski et al., 1996)

Additional Descriptive Data

lbm protein, a cell surface protein, is transiently expressed along the entire length of motor axons, including their growth cones and presynaptic terminals. The protein is present in late embryogenesis,but disappears by third larval instar.

(Kopczynski et al., 1996)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in extracellular region

inferred from direct assay

(Kopczynski et al., 1996)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\lbm in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\lbm

View exonic expression by tissue for Dmel\lbm

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0016032

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35623/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0016032

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0016032

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0016032

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2374

Flygut - An atlas of the Drosophila adult midgut

FBgn0016032

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\lbm

Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of lbm

Transgenic constructs containing regulatory region of lbm

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2R)Δ42E

(Lin et al., 2005)

Df(2R)Exel6283

(Ryder, 2004.4.26)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

lbm^GD1843

viable, with Scer\GAL4^Mef2.PR

lbm^GD1843

viable, with Scer\GAL4^pnr-MD237

lbm^GD1843

Other Phenotypes

Allele

abnormal neuroanatomy

lbm^Y13

abnormal neuroanatomy, with Scer\GAL4^elav-C155

lbm^EY02692

abnormal neuroanatomy | embryonic stage

lbm^Y13

Phenotype manifest in

Allele

growth cone

lbm^Y13

larval VL3/4 motor neuron

presynaptic ribbon

lbm^Y13

RP3 neuron & synapse

lbm^Y13

synapse

lbm^Y13

synapse, with Scer\GAL4^elav-C155

lbm^EY02692

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (32)

Hsap\TSPAN11

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (27)

Rnor\Cd9

2 of 14

Yes

Rnor\Cd37

2 of 14

Yes

Rnor\Cd53

2 of 14

Yes

Rnor\Cd63

2 of 14

Yes

Rnor\Cd81

2 of 14

Yes

Rnor\Cd82

2 of 14

Yes

Rnor\Tspan1

2 of 14

Yes

Rnor\Tspan2

2 of 14

Yes

Rnor\Tspan3

2 of 14

Yes

Rnor\Tspan5

2 of 14

Yes

Rnor\Tspan6

2 of 14

Yes

Rnor\Tspan8

2 of 14

Yes

Rnor\Tspan11

2 of 14

Yes

Rnor\Tspan15

2 of 14

Yes

Rnor\Tspan33

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mus musculus (laboratory mouse) (30)

Mmus\Tspan11

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (13)

Xtro\cd53

1 of 13

Yes

Xtro\cd81

1 of 13

Yes

Xtro\LOC100492951

1 of 13

Yes

Xtro\pds5a

1 of 13

Yes

Xtro\slc25a12

1 of 13

Yes

Xtro\stam

1 of 13

Yes

Xtro\tspan3

1 of 13

Yes

Xtro\tspan5

1 of 13

Yes

Xtro\tspan7

1 of 13

Yes

Xtro\tspan9

1 of 13

Yes

Xtro\tspan14

1 of 13

Yes

Xtro\tspan18

1 of 13

Yes

Xtro\zmym4

1 of 13

Yes

Danio rerio (Zebrafish) (48)

Drer\cd9a

2 of 14

Yes

Drer\cd9b

2 of 14

Yes

Drer\cd63

2 of 14

Yes

Drer\cd81a

2 of 14

Yes

Drer\cd81b

2 of 14

Yes

Drer\cd82a

2 of 14

Yes

Drer\cd82b

2 of 14

Yes

Drer\cd151

2 of 14

Yes

Drer\cd151l

2 of 14

Yes

Drer\si:ch73-139j3.4

2 of 14

Yes

Drer\tspan1

2 of 14

Yes

Drer\tspan2a

2 of 14

Yes

Drer\tspan3b

2 of 14

Yes

Drer\tspan4b

2 of 14

Yes

Drer\tspan5a

2 of 14

Yes

Drer\tspan5b

2 of 14

Yes

Drer\tspan7b

2 of 14

Yes

Drer\tspan7

2 of 14

Yes

Drer\tspan9a

2 of 14

Yes

Drer\tspan9b

2 of 14

Yes

Drer\tspan11

2 of 14

Yes

Drer\tspan15

2 of 14

Yes

Drer\tspan18a

2 of 14

Yes

Drer\tspan18b

2 of 14

Yes

Drer\tspan33a

2 of 14

Yes

Drer\tspan36

2 of 14

Yes

Drer\upk1a

2 of 14

Yes

Drer\zgc:64051

2 of 14

Yes

Drer\zgc:113223

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (17)

Cele\tsp-4

2 of 14

Yes

Cele\tsp-5

2 of 14

Yes

Cele\tsp-6

2 of 14

Yes

Cele\tsp-7

2 of 14

Yes

Cele\tsp-8

2 of 14

Yes

Cele\tsp-9

2 of 14

Yes

Cele\tsp-11

2 of 14

Yes

Cele\tsp-12

2 of 14

Yes

Cele\tsp-13

2 of 14

Yes

Cele\tsp-21

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (17)

Agam\AgaP_AGAP000823

2 of 12

Yes

Agam\AgaP_AGAP002257

2 of 12

Yes

Agam\AgaP_AGAP004861

2 of 12

Yes

Agam\AgaP_AGAP005233

2 of 12

Yes

Agam\AgaP_AGAP007209

2 of 12

Yes

Agam\AgaP_AGAP007210

2 of 12

Yes

Agam\AgaP_AGAP008527

2 of 12

Yes

Agam\AgaP_AGAP008647

2 of 12

Yes

Agam\AgaP_AGAP008886

2 of 12

Yes

Agam\AgaP_AGAP009651

2 of 12

Yes

Agam\AgaP_AGAP009653

2 of 12

Yes

Agam\AgaP_AGAP010598

2 of 12

Yes

Agam\AgaP_AGAP011342

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (1)

Atha\TET10

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:lbm. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (36)

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

TSPAN11; tetraspanin 11

3 of 14

621013

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

kay

suppressible

lbm

(Franciscovich et al., 2008)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0016032

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neutrophil degranulation

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-55

Cytogenetic map

42E6-42E6

Sequence location

2R:7,049,238..7,051,964 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

42E6-42E6

Limits computationally determined from genome sequence between P{lacW}vimar^k16722 and P{lacW}cos^k16101

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

42F1-42F1

(Kopczynski, 1996.2.12)

Experimentally Determined Recombination Data

Location

2-55

(FlyBase, 2016)

2-56.3

(Comeron et al., 2012)

(Kopczynski, 1996.2.12)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

27278

y¹ v¹; P{TRiP.JF02589}attP2

65640

w¹¹¹⁸; PBac{IT.GAL4}lbm^1252-G4

44781

y¹ w^*; Mi{MIC}lbm^MI08469

15583

y¹ w^67c23; P{EPgy2}lbm^EY02692

34173

y¹ w^*; Mi{MIC}lbm^MI01271/SM6a

35459

y¹ sc^* v¹ sev²¹; P{TRiP.GL00385}attP2

NIG-Fly

GL00385

y¹ sc^* v¹ sev²¹; P{TRiP.GL00385}attP2

2RG-1232

y² VhaAC39-1^cho-1 v¹; P{U6-lbm.NIG.sgRNA}attP40/CyO

VDRC

v102739

P{KK112318}VIE-260B

v7937

w¹¹¹⁸; P{GD1843}v7937

Genomic Clones (24)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (14)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE57845

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0016032

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0016032

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Kopczynski et al., 1996)

Commercially Available Antibodies

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

10C9_anti-late_bloomer

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Expression is enriched in embryonic gonads.

(Shigenobu et al., 2006)

lbm encodes a neural tetraspanin that facilitates synapse formation.

(Kopczynski et al., 1996)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: lbm CG2374

(Shue, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

CG2374

(National Institute of Genetics Fly Stocks, 2022-, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Fradkin et al., 2002, Todres et al., 2000)

Dm.Tsp42Em

(Todres et al., 2000)

Ibm

(Franciscovich et al., 2008)

LBM

(Brooks et al., 2011)

Lbm

(González-Méndez et al., 2020, Parchure et al., 2015, Beckett et al., 2013, Koles et al., 2012, Kopczynski et al., 1998)

lbl

(Todres et al., 2000, Lear et al., 1999, Kopczynski, 1996.2.12, Kopczynski et al., 1996)

lbm

(Dong et al., 2025, González-Méndez et al., 2020, Clandinin and Owens, 2016-, Crocker et al., 2016, Jeibmann et al., 2015, Perkins et al., 2009.8.10, Franciscovich et al., 2008, Shigenobu et al., 2006)

Name Synonyms

Late Bloomer

(Tran and Doe, 2008, Roush, 1996)

Late bloomer

(Parchure et al., 2015, Beckett et al., 2013)

late bloomer

(Ramond et al., 2020, Jeibmann et al., 2015, Hong et al., 2012, Brooks et al., 2011, Edwards et al., 2009)

latebloomer

(Kamphorst et al., 2002)

tetraspanin 42E

(Silverman et al., 2003)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 38 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35623

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q24188

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q24188

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0B4KF78

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q24188

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0016032

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35623/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0016032

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0016032

FlyMine - An integrated database for Drosophila genomics

FBgn0016032

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG2374

MARRVEL_MODEL - MARRVEL (model organism gene)

35623

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0016032

DroID - A comprehensive database of gene and protein interactions.

FBgn0016032

DRSC - Results frm RNAi screens

FBgn0016032

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

10C9_anti-late_bloomer

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

lbm_1
lbm_2

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0016032

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0016032

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2374

Flygut - An atlas of the Drosophila adult midgut

FBgn0016032

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neutrophil degranulation

References (63)

The following external sites may use different assemblies or annotations than FlyBase.

-1.13

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