FlyBase Gene Report: Dmel\Tsp42Ej

General Information

Symbol

Dmel\Tsp42Ej

Species

D. melanogaster

Name

Tetraspanin 42Ej

Annotation Symbol

CG12143

Feature Type

protein_coding_gene

FlyBase ID

FBgn0033132

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Summary

Tetraspanin 42Ej (Tsp42Ej) encodes a lysosomal member protein required for the degradation of endocytosed rhodopsin. It prevents light-induced retinal degeneration. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Sunglasses, sun

Key Links

Genomic Location

Cytogenetic map

42E5-42E5

Sequence location

2R:7,040,136..7,042,762 [+]

Recombination map

2-55

RefSeq locus

NT_033778 REGION:7040136..7042762

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in cellular response to high light intensity

inferred from mutant phenotype

(Xu et al., 2004)

involved_in endocytosis

inferred from mutant phenotype

(Han et al., 2007)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in lysosome

inferred from direct assay

(Xu et al., 2004)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR008952, InterPro:IPR018499

(InterPro Project Members, 2004-)

inferred from sequence model

(Xu et al., 2004, Fradkin et al., 2002)

inferred from sequence or structural similarity

(Todres et al., 2000)

Gene Group (FlyBase)

TETRASPANINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Tetraspanin 42Ej (Tsp42Ej) encodes a lysosomal member protein required for the degradation of endocytosed rhodopsin. It prevents light-induced retinal degeneration. [Date last reviewed: 2019-03-14]

Gene Group (FlyBase)

TETRASPANINS -: Tetraspanins (TSP) have four transmembrane domains and two extracellular loops containing specific short motifs, including highly conserved cysteine residues. TSPs are thought to function as scaffolds that bring multiple proteins - including other TSPs, membrane-associated proteins, extracellular and cytosolic proteins - into single membrane region. These regions are called tetraspanin-enriched microdomains. (Adapted from FBrf0227776 and FBrf0152316).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Tsp42Ej for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7K3Z2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.48

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Tsp42Ej-RA

FBtr0089030

NM_078912

1116

227

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Tsp42Ej-PA

FBpp0088101

25.3

227

6.94

Q7K3Z2

NP_523636

AAF59305

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q7K3Z2

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tsp42Ej using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.75

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

eye

(Xu et al., 2004)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic esophagus

(Fisher et al., 2012)

embryonic head epidermis

(Fisher et al., 2012)

embryonic/larval garland cell

(Fisher et al., 2012)

larval nervous system

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

eye

(Xu et al., 2004)

Additional Descriptive Data

Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads.

(Xu et al., 2004)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

distribution deduced from reporter or direct label

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

photoreceptor neuron

• lysosome

(Xu et al., 2004)

immuno-electron microscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

photoreceptor neuron

• vesicle

(Xu et al., 2004)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in lysosome

inferred from direct assay

(Xu et al., 2004)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Tsp42Ej in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Tsp42Ej

View exonic expression by tissue for Dmel\Tsp42Ej

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0033132

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35620/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0033132

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0033132

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0033132

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12143

Flygut - An atlas of the Drosophila adult midgut

FBgn0033132

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Tsp42Ej

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Tsp42Ej

Transgenic constructs containing regulatory region of Tsp42Ej

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2R)Δ42E

(Lin et al., 2005)

Df(2R)Exel6283

(Ryder, 2004.4.26)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Tsp42Ej^d01125

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Tsp42Ej^GD1842

viable, with Scer\GAL4^Mef2.PR

Tsp42Ej^GD1842

viable, with Scer\GAL4^pnr-MD237

Tsp42Ej^GD1842

Sterility

Allele

fertile

Tsp42Ej^d01125

Other Phenotypes

Allele

visible, with Scer\GAL4^pnr-MD237

Tsp42Ej^GD1842

Phenotype manifest in

Allele

retina

Tsp42Ej¹

trichogen cell, with Scer\GAL4^pnr-MD237

Tsp42Ej^GD1842

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (31)

Hsap\CD37

3 of 14

Yes

Hsap\CD53

3 of 14

Yes

Hsap\CD81

3 of 14

Yes

Hsap\CD82

3 of 14

Yes

Hsap\TSPAN2

3 of 14

Yes

Hsap\TSPAN3

3 of 14

Yes

Hsap\TSPAN4

3 of 14

Yes

Hsap\TSPAN9

3 of 14

Yes

Hsap\TSPAN19

3 of 14

Yes

Hsap\UPK1B

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (29)

Rnor\Cd9

3 of 14

Yes

Rnor\Cd37

3 of 14

Yes

Rnor\Cd53

3 of 14

Yes

Rnor\Cd81

3 of 14

Yes

Rnor\Cd82

3 of 14

Yes

Rnor\Tspan1

3 of 14

Yes

Rnor\Tspan2

3 of 14

Yes

Rnor\Tspan3

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Upk1b

1 of 14

Mus musculus (laboratory mouse) (30)

Mmus\Cd9

3 of 14

Yes

Mmus\Cd37

3 of 14

Yes

Mmus\Cd53

3 of 14

Yes

Mmus\Cd81

3 of 14

Yes

Mmus\Cd82

3 of 14

Yes

Mmus\Tspan1

3 of 14

Yes

Mmus\Tspan2

3 of 14

Yes

Mmus\Tspan3

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (21)

Xtro\cd53

2 of 13

Yes

Xtro\cd81

2 of 13

Yes

Xtro\tspan3

2 of 13

Yes

Xtro\tspan9

2 of 13

Yes

Xtro\tspan18

2 of 13

Yes

Xtro\cd37

1 of 13

Xtro\cd82

1 of 13

Xtro\dkkx

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\zmym4

1 of 13

Danio rerio (Zebrafish) (49)

Drer\cd9b

3 of 14

Yes

Drer\cd81a

3 of 14

Yes

Drer\cd81b

3 of 14

Yes

Drer\cd82a

3 of 14

Yes

Drer\cd82b

3 of 14

Yes

Drer\si:ch73-139j3.4

3 of 14

Yes

Drer\tspan2a

3 of 14

Yes

Drer\tspan3b

3 of 14

Yes

Drer\tspan4b

3 of 14

Yes

Drer\tspan9b

3 of 14

Yes

Drer\tspan18a

3 of 14

Yes

Drer\tspan18b

3 of 14

Yes

Drer\tspan36

3 of 14

Yes

Drer\tspan37

3 of 14

Yes

Drer\upk1a

3 of 14

Yes

Drer\zgc:64051

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (17)

Cele\tsp-4

3 of 14

Yes

Cele\tsp-5

3 of 14

Yes

Cele\tsp-6

3 of 14

Yes

Cele\tsp-7

3 of 14

Yes

Cele\tsp-11

3 of 14

Yes

Cele\tsp-21

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (17)

Agam\AgaP_AGAP011342

3 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (1)

Atha\TET10

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Tsp42Ej. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (36)

CG30160

3 of 13

lbm

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

CD81; CD81 molecule

model of common variable immunodeficiency 6

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

3 of 14

3 of 14

3 of 14

IMMUNODEFICIENCY, COMMON VARIABLE, 6; CVID6

common variable immunodeficiency 6

CD82; CD82 molecule

3 of 14

600623

TSPAN2; tetraspanin 2

3 of 14

613133

TSPAN3; tetraspanin 3

3 of 14

613134

TSPAN4; tetraspanin 4

3 of 14

602644

TSPAN9; tetraspanin 9

3 of 14

613137

TSPAN19; tetraspanin 19

3 of 14

UPK1B; uroplakin 1B

3 of 14

602380

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Tsp42Ej - Gαq

pull down, anti tag western blot

(Han et al., 2007)

Tsp42Ej - ninaE

anti bait coimmunoprecipitation, western blot

(Xu et al., 2004)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Tsp42Ej

suppressible

ninaE

(Xu et al., 2004)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

61509

DroID - A comprehensive database of gene and protein interactions.

FBgn0033132

MIST (protein-protein) - An integrated Molecular Interaction Database

35620

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-55

Cytogenetic map

42E5-42E5

Sequence location

2R:7,040,136..7,042,762 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

42E5-42E5

Limits computationally determined from genome sequence between P{lacW}vimar^k16722 and P{lacW}cos^k16101

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-55

(FlyBase, 2016)

2-56.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

27335

w^*; Tsp42Ej¹

19159

w¹¹¹⁸; P{XP}Tsp42Ej^d01125

29392

y¹ v¹; P{TRiP.JF03325}attP2/TM3, Sb¹

83261

y¹ w^*; TI{CRIMIC.TG4.0}Tsp42Ej^{CR01312-TG4.0}

NIG-Fly

12143R-1

P{NIG.12143R}1

12143R-3

P{NIG.12143R}3

2RG-1122

y² VhaAC39-1^cho-1 v¹; P{U6-Tsp42Ej.NIG.sgRNA}attP40/CyO

VDRC

v105191

P{KK112458}VIE-260B

v7350

w¹¹¹⁸; P{GD1842}v7350

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (74)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH01773

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0033132

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0033132

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Identification: In a comprehensive microarray analysis for eye-enriched genes in the Drosophila genome, to identify new loci implicated in visual transduction or retinal degeneration. Tsp42Ej is a member of the tetraspanin protein encoding family.

(Xu et al., 2003)

Tsp42Ej may attenuate signaling from light illumination through down regulation of the rhodopsin level.

(Xu et al., 2003)

Mutation of Tsp42Ej locus induced slow, light dependent retinal degeneration. This rescue of photoresponse appeared to result from rescue of rhodopsin protein level.

(Xu et al., 2003)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Tsp42Ej CG12143

(Todres et al., 2000)

Source for identity of: Tsp42Ej sunglass

(Xu, 2003.2.10)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG12143

(National Institute of Genetics Fly Stocks, 2022-, Park et al., 2011, Keleman et al., 2009.8.5, Perkins et al., 2009, Yang et al., 2005, Xu et al., 2004, Fradkin et al., 2002, Todres et al., 2000)

Dm.Tsp42Ej

(Todres et al., 2000)

Sun

(Williamson et al., 2010, Venkatachalam et al., 2006, Xu et al., 2003)

Tsp42Ej

(Tsai et al., 2019, Gene Disruption Project members, 2018-, Fox and Andrew, 2015, Jeibmann et al., 2015, Japanese National Institute of Genetics, 2012.5.21, Park et al., 2011)

sun

(Han et al., 2007, Lee and Montell, 2004, Xu et al., 2004)

tsp42ej

(Brandt et al., 2008)

Name Synonyms

CG12143

(Yang et al., 2005)

Sunglasses

(Williamson et al., 2010, Han et al., 2007, Venkatachalam et al., 2006)

Tetraspanin 42Ej

(Jeibmann et al., 2015, Xu, 2003.2.10, Todres et al., 2000)

sunglass

(Xu et al., 2003)

sunglasses

(Lee and Montell, 2004, Xu et al., 2004)

tetraspanin 42E

(Silverman et al., 2003)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 31 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35620

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7K3Z2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q7K3Z2

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7K3Z2

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0033132

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35620/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0033132

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0033132

FlyMine - An integrated database for Drosophila genomics

FBgn0033132

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG12143

MARRVEL_MODEL - MARRVEL (model organism gene)

35620

Linkouts

BioGRID - A database of protein and genetic interactions.

61509

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0033132

DroID - A comprehensive database of gene and protein interactions.

FBgn0033132

DRSC - Results frm RNAi screens

FBgn0033132

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0033132

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0033132

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12143

Flygut - An atlas of the Drosophila adult midgut

FBgn0033132

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0033132

MIST (protein-protein) - An integrated Molecular Interaction Database

35620

References (47)

The following external sites may use different assemblies or annotations than FlyBase.

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