FB2026_02 , released June 18, 2026
Gene: Rat\CamKII-I
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General Information
Symbol
Rat\CamKII-I
Species
R. unknown
Name
CaM kinase α autoinhibitory domain
Annotation Symbol
Feature Type
engineered_foreign_region
FlyBase ID
FBgn0016128
Gene Model Status
Not Applicable
Stock Availability
1 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

CaMKII

Foreign Gene Data

Foreign sequence; species == Rattus; sequence == 'CamKII-I, CaM kinase α autoinhibitory domain' {aminoacid residues 273--302}.

(FlyBase Curators, 1992-)
Summaries
Alleles, Insertions, Transgenic Constructs
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Rat\CamKII-I
Transgenic constructs containing regulatory region of Rat\CamKII-I
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Other Phenotypes
Allele
abnormal behavior
abnormal neuroanatomy
abnormal neuroanatomy, with Scer\GAL4Toll-6-D42
abnormal neuroanatomy, with Scer\GAL4unspecified
abnormal neuroanatomy | larval stage, with Scer\GAL4Toll-6-D42
abnormal neuroanatomy | somatic clone, with Scer\FLP1UAS.cUa, Scer\GAL4Act.PU, Scer\GAL4eve.RRK
abnormal neurophysiology
abnormal neurophysiology, with Scer\GAL4eve.RRa
abnormal neurophysiology, with Scer\GAL4Mef2.PR
abnormal neurophysiology, with Scer\GAL4Mhc.PW
abnormal neurophysiology | third instar larval stage, with Scer\GAL4how-24B
abnormal size | larval stage, with Scer\GAL4Toll-6-D42
Phenotype manifest in
Allele
axon | larval stage, with Scer\GAL4Toll-6-D42
bouton
dendrite | somatic clone, with Scer\FLP1UAS.cUa, Scer\GAL4Act.PU, Scer\GAL4eve.RRK
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4how-24B
larval abdominal segmental nerve
larval RP2 motor neuron | somatic clone, with Scer\FLP1UAS.cUa, Scer\GAL4Act.PU, Scer\GAL4eve.RRK
larval VL3/4 motor neuron
larval VO1 motor neuron
larval VO2 motor neuron
neuromuscular junction
neuromuscular junction & postsynaptic membrane, with Scer\GAL4unspecified
neuromuscular junction | larval stage, with Scer\GAL4Toll-6-D42
neuron
presynaptic active zone | larval stage, with Scer\GAL4Toll-6-D42
synapse
synapse, with Scer\GAL4Toll-6-D42
t-bar, with Scer\GAL4Mhc.PW
Orthologs
Downloads
Download All DIOPT Orthologs
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Drosophila melanogaster (Fruit fly) (0)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Rat\CamKII-IAla.UAS
    ameliorates  tauopathy
    modeled by Hsap\MAPTUAS.cWa
    (Oka et al., 2017)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Interaction Browsers
    Summary of Genetic Interactions
    Interaction Browsers
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Class of Gene
    Stocks and Reagents
    Other Comments

    There are parallels in the physiological and behavioural phenotypes caused by eag mutations and Rat\CamKII-I. Interactions of eag and Rat\CamKII-I have been investigated at the behavioural, physiological, genetical and biochemical level.

    (Griffith et al., 1994)

    Study of transformed lines expressing a specific inhibitor of CaMKII (Rat\CamKII-I) suggests an important role of CaMKII in the stability of synaptic transmission.

    (Wang et al., 1994)
    Relationship to Other Genes
    Source for database merge of
    Additional comments
    Nomenclature History
    Source for database identify of
    Nomenclature comments
    Etymology
    Synonyms and Secondary IDs (7)
    Reported As
    Symbol Synonym
    Ala
    (Haghighi et al., 2003)
    CKII
    (Karagas et al., 2022)
    CaMKII
    (Harrisingh et al., 2007, van der Plas et al., 2006)
    CamKII
    (Lee et al., 2009)
    Rat\CamKII-I
    α CaM kinase
    (Broughton et al., 1996)
    Name Synonyms
    CaM kinase α autoinhibitory domain
    Secondary FlyBase IDs
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      Study result (0)
      Result
      Result Type
      Title
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      References (35)