FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Pgm2b
Open Close
General Information
Symbol
Dmel\Pgm2b
Species
D. melanogaster
Name
Phosphoglucomutase 2b
Annotation Symbol
CG10202
Feature Type
protein_coding_gene
FlyBase ID
FBgn0033969
Gene Model Status
Current
Stock Availability
6 publicly available
Enzyme Name (EC)
phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (5.4.2.2)
phosphopentomutase (5.4.2.7)
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
51C4-51C4
Sequence location
Recombination map
2-72
RefSeq locus
NT_033778 REGION:14817857..14819987
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables intramolecular phosphotransferase activity
inferred from electronic annotation with InterPro:IPR005844, InterPro:IPR005846, InterPro:IPR016055
(InterPro Project Members, 2004-)
inferred from electronic annotation with InterPro:IPR005844, InterPro:IPR016055
(InterPro Project Members, 2004-)
enables phosphoglucomutase activity
inferred from sequence or structural similarity with UniProtKB:Q96G03
(Gene Ontology Curators, 2002-)
enables phosphopentomutase activity
inferred from biological aspect of ancestor with PANTHER:PTN001860097
(GO Reference Genome Project, 2011-)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in carbohydrate metabolic process
(InterPro Project Members, 2004-)
inferred from electronic annotation with InterPro:IPR005844, InterPro:IPR005845, InterPro:IPR016055
(InterPro Project Members, 2004-)
involved_in purine ribonucleoside salvage
inferred from biological aspect of ancestor with PANTHER:PTN001860097
(GO Reference Genome Project, 2011-)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
phosphoglucomutase activity
alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (5.4.2.2)
RHEA 23536: phosphopentomutase activity
alpha-D-ribose 1-phosphate = D-ribose 5-phosphate (5.4.2.7)
Summaries
Gene Group (FlyBase)
INTRAMOLECULAR PHOSPHOTRANSFERASES -
Intramolecular phosphotransferases catalyze the transfer of a phosphate group from one part of a molecule to another. (Adapted from FBrf0238665.)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Pgm2b for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A1Z9V3)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.50

Gene model reviewed during 5.44

Gene model reviewed during 5.56

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Pgm2b-RA
FBtr0087464
NM_137148
2059
628
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Pgm2b-PA
FBpp0086594
71.3
628
5.04
A1Z9V3
NP_610992
AAF58201
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pgm2b using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

5.06

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood | male -- day 7 of adulthood | male
spermatozoon
(Wasbrough et al., 2010, Dorus et al., 2006)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Pgm2b in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Pgm2b
Transgenic constructs containing regulatory region of Pgm2b
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (5)
Hsap\PGM2
13 of 14
Yes
Yes
Hsap\PGM2L1
12 of 14
No
Yes
Hsap\PGM1
1 of 14
No
No
Hsap\PGM3
1 of 14
No
No
Hsap\PGM5
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (5)
Rnor\Pgm2l1
12 of 14
Yes
Yes
Rnor\Pgm2
12 of 14
Yes
Yes
Rnor\Pgm1
1 of 14
No
No
Rnor\Pgm3
1 of 14
No
No
Rnor\Pgm5
1 of 14
No
No
Mus musculus (laboratory mouse) (5)
Mmus\Pgm2l1
12 of 14
Yes
Yes
Mmus\Pgm2
12 of 14
Yes
Yes
Mmus\Pgm1
1 of 14
No
No
Mmus\Pgm3
1 of 14
No
No
Mmus\Pgm5
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (3)
Xtro\pgm2l1
10 of 13
Yes
Yes
Xtro\pgm2
8 of 13
No
Yes
Xtro\siae
1 of 13
No
Yes
Danio rerio (Zebrafish) (8)
Drer\pgm2
13 of 14
Yes
Yes
Drer\pgm2l1
12 of 14
No
Yes
Drer\hprt1l
1 of 14
No
Yes
Drer\pgm1
1 of 14
No
No
Drer\pgm3
1 of 14
No
No
Drer\pgm5
1 of 14
No
No
Drer\prtfdc1a
1 of 14
No
Yes
Drer\prtfdc1b
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\Y43F4B.5
13 of 14
Yes
Yes
Cele\F21D5.1
1 of 14
No
No
Cele\R05F9.6
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (3)
Agam\AgaP_AGAP008305
6 of 12
Yes
No
Agam\AgaP_AGAP005860
1 of 12
No
No
Agam\AgaP_AGAP007215
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (6)
Atha\AT1G70820
3 of 13
Yes
Yes
Atha\AT5G17530
3 of 13
Yes
Yes
Atha\DRT101
1 of 13
No
No
Atha\PGM2
1 of 13
No
No
Atha\PGM3
1 of 13
No
No
Atha\PGM
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\PRM15
13 of 13
Yes
Yes
Scer\PCM1
1 of 13
No
No
Scer\PGM1
1 of 13
No
No
Scer\PGM2
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\SPCC1840.05c
12 of 12
Yes
Yes
Spom\SPAC13C5.05c
1 of 12
No
No
Spom\SPAC1296.01c
1 of 12
No
No
Spom\SPBC32F12.10
1 of 12
No
No
Escherichia coli (enterobacterium) (3)
Ecol\cpsG
2 of 11
Yes
Yes
Ecol\glmM
2 of 11
Yes
No
Ecol\pgm
1 of 11
No
No
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Pgm2b. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (3)
Pgm2a
13 of 13
nst
2 of 13
Pgm1
2 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PGM2; phosphoglucomutase 2
    13 of 14
    172000
        PGM2L1; phosphoglucomutase 2 like 1
        12 of 14
        611610
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          Interaction Browsers
          Summary of Genetic Interactions
          Interaction Browsers
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          External Data
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          External Data
          Linkouts
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Class of Gene
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          2R
          Recombination map
          2-72
          Cytogenetic map
          51C4-51C4
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          51C4-51C4
          Limits computationally determined from genome sequence between P{lacW}Rpn6k00103 and P{PZ}chn02064
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          Experimentally Determined Recombination Data
          Location

          2-72

          (FlyBase, 2016)

          2-76.5

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (6)
          Genomic Clones (19)
          cDNA Clones (25)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments
              Relationship to Other Genes
              Source for database merge of

              Source for merge of: CG10202 anon-WO0140519.148

              (FlyBase, 1996-)
              Additional comments

              Source for merge of CG10202 anon-WO0140519.148 was sequence comparison ( date:051113 ).

              (FlyBase, 1996-)
              Nomenclature History
              Source for database identify of

              Source for identity of: Pgm2b CG10202

              (FlyBase, 2017-)
              Nomenclature comments

              There are two D. melanogaster genes called as clear orthologs to the human PGM2 (phosphoglucomutase 2) gene - CG8073 and CG10202, named here as Pgm2a and Pgm2b, respectively.

              (FlyBase, 2017-)
              Etymology

              Named 'Pgm2b' after the human ortholog.

              (FlyBase, 2017-)
              Synonyms and Secondary IDs (4)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 60 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
              KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
              References (34)