FlyBase Gene Report: Dmel\Mctp

General Information

Symbol

Dmel\Mctp

Species

D. melanogaster

Name

Multiple C2 domain and transmembrane region protein

Annotation Symbol

CG15078

Feature Type

protein_coding_gene

FlyBase ID

FBgn0034389

Gene Model Status

Current

Stock Availability

8 publicly available

Gene Summary

Multiple C2 domain and transmembrane region protein (Mctp) encodes a regulator of both neuronal synaptic plasticity and neurotransmitter secretion. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

55F1-55F2

Sequence location

2R:18,761,758..18,774,824 [+]

Recombination map

2-86

RefSeq locus

NT_033778 REGION:18761758..18774824

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables calcium ion binding

inferred from direct assay

(Genç et al., 2017)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables calcium ion binding

inferred from sequence or structural similarity with UniProtKB:Q6DN14

(Shin et al., 2005)

inferred from biological aspect of ancestor with PANTHER:PTN002473508

(GO Reference Genome Project, 2011-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in regulation of neuronal synaptic plasticity

inferred from mutant phenotype

(Genç et al., 2017)

involved_in regulation of neurotransmitter secretion

inferred from mutant phenotype

(Genç et al., 2017)

involved_in synaptic vesicle exocytosis

inferred from mutant phenotype

(Genç et al., 2017)

inferred from direct assay

(Genç et al., 2017)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of neurotransmitter secretion

inferred from biological aspect of ancestor with PANTHER:PTN000413636

(GO Reference Genome Project, 2011-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in endoplasmic reticulum membrane

inferred from direct assay

(Genç et al., 2017)

is_active_in neuromuscular junction

inferred from mutant phenotype

(Genç et al., 2017)

inferred from direct assay

(Genç et al., 2017)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from sequence or structural similarity with UniProtKB:Q6DN14

(Shin et al., 2005)

is_active_in synaptic vesicle membrane

inferred from biological aspect of ancestor with PANTHER:PTN000413636

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Multiple C2 domain and transmembrane region protein (Mctp) encodes a regulator of both neuronal synaptic plasticity and neurotransmitter secretion. [Date last reviewed: 2019-09-12]

Protein Function (UniProtKB)

Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity (PubMed:28485711).

(UniProt, A1ZBD6)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Mctp for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A1ZBD6)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.56

Stop-codon suppression (UAG) postulated; FBrf0216884

Gene model reviewed during 5.44

Gene model reviewed during 5.50

Gene model reviewed during 6.02

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Mctp-RA

FBtr0110970

NM_137528

4066

893

Mctp-RB

FBtr0110971

NM_001043095

2824

596

Mctp-RD

FBtr0330004

NM_001274149

4123

982

Mctp-RE

FBtr0330005

NM_001043094

4015

954

Mctp-RF

FBtr0345950

NM_001299661

4223

893

Mctp-RG

FBtr0346955

NM_001316428

4123

912

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Mctp-PA

FBpp0110270

101.1

893

7.24

NP_611372

AAO41353

Mctp-PB

FBpp0110271

69.1

596

7.52

FBpp0303039

110.6

982

8.26

FBpp0303040

108.1

954

8.22

FBpp0311864

101.1

893

7.24

NP_001286590

AHN56385

Mctp-PG

FBpp0312419

103.5

912

7.67

A1ZBD6

NP_001303357

ALI30186

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

893 aa isoforms: Mctp-PA, Mctp-PF

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mctp using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.12

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

Comment: rapidly degraded

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in endoplasmic reticulum membrane

inferred from direct assay

(Genç et al., 2017)

is_active_in neuromuscular junction

inferred from mutant phenotype

(Genç et al., 2017)

inferred from direct assay

(Genç et al., 2017)

Expression Deduced from Reporters

Reporter: P{GT1}Mctp^BG01140b

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

eo sensory organ accessory cell of olfactory sensory organ | subset

(Tunstall et al., 2012)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Mctp in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Mctp

View exonic expression by tissue for Dmel\Mctp

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0034389

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37165/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0034389

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0034389

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0034389

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG33146

Flygut - An atlas of the Drosophila adult midgut

FBgn0034389

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Mctp

Transgenic constructs containing regulatory region of Mctp

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2R)Exel7158

(Ryder, 2004.4.26)

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

Mctp^BG01140b

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Mctp^GD2076

viable, with Scer\GAL4^Mef2.PR

Mctp^GD2076

viable, with Scer\GAL4^pnr-MD237

Mctp^GD2076

viable, with Scer\GAL4^tin.CΔ4

Mctp^GD2076

Sterility

Allele

fertile

Mctp^e00415

Other Phenotypes

Allele

abnormal heat stress response | third instar larval stage, with Scer\GAL4^ppk.1.9

Mctp^KK104930

abnormal neuroanatomy | third instar larval stage

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^ppk.1.9

Mctp^KK104930

abnormal neurophysiology | third instar larval stage

Phenotype manifest in

Allele

dendrite | third instar larval stage, with Scer\GAL4^ppk.1.9

Mctp^KK104930

embryonic/larval neuromuscular junction | third instar larval stage

larval dorsal multidendritic neuron ddaC | third instar larval stage, with Scer\GAL4^ppk.1.9

Mctp^KK104930

NMJ bouton | third instar larval stage

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (52)

Hsap\MCTP1

14 of 14

Yes

Hsap\MCTP2

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\PLA2G4F

1 of 14

Yes

Hsap\PRF1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (29)

Rnor\Mctp1

13 of 14

Yes

Rnor\Mctp2

12 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Prf1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mus musculus (laboratory mouse) (31)

Mmus\Mctp1

14 of 14

Yes

Mmus\Mctp2

13 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (35)

Xtro\mctp2

10 of 13

Yes

Xtro\mctp1

8 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\myof.1

1 of 13

Xtro\pla2g4a

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (66)

Drer\mctp1a

13 of 14

Yes

Drer\mctp1b

13 of 14

Yes

Drer\mctp2b

13 of 14

Yes

Drer\mctp2a

11 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\prf1.2

1 of 14

Yes

Drer\prf1.3

1 of 14

Yes

Drer\prf1.5

1 of 14

Yes

Drer\prf1.6

1 of 14

Yes

Drer\prf1.7

1 of 14

Yes

Drer\prf1.8

1 of 14

Yes

Drer\prf1.9

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:ch211-240l19.5

1 of 14

Yes

Drer\si:ch211-240l19.6

1 of 14

Yes

Drer\si:ch211-240l19.7

1 of 14

Yes

Drer\si:ch211-240l19.8

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (14)

Cele\mctp-1

13 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\unc-13

1 of 14

Cele\W09D10.1

1 of 14

Anopheles gambiae (African malaria mosquito) (17)

Agam\AgaP_AGAP007646

12 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (55)

Atha\AT3G61300

9 of 13

Yes

Atha\AT1G22610

7 of 13

Yes

Atha\AT1G51570

7 of 13

Yes

Atha\AT3G57880

7 of 13

Yes

Atha\AT4G00700

7 of 13

Yes

Atha\AT4G11610

7 of 13

Yes

Atha\AT5G12970

7 of 13

Yes

Atha\AT5G48060

7 of 13

Yes

Atha\FTIP1

7 of 13

Yes

Atha\AT1G04150

6 of 13

Yes

Atha\AT3G03680

6 of 13

Yes

Atha\AT4G20080

6 of 13

Yes

Atha\AT5G17980

6 of 13

Yes

Atha\QKY

6 of 13

Yes

Atha\AT3G61720

5 of 13

Yes

Atha\AT5G03435

5 of 13

Yes

Atha\AT5G44760

5 of 13

Yes

Atha\AT1G70790

3 of 13

Yes

Atha\AT2G01540

3 of 13

Yes

Atha\AT3G07940

3 of 13

Yes

Atha\AT5G47710

3 of 13

Yes

Atha\AGD13

2 of 13

Yes

Atha\AT1G23140

2 of 13

Yes

Atha\AT1G48590

2 of 13

Yes

Atha\AT1G63220

2 of 13

Yes

Atha\AT1G66360

2 of 13

Yes

Atha\AT1G70810

2 of 13

Yes

Atha\AT1G73580

2 of 13

Yes

Atha\AT3G55470

2 of 13

Yes

Atha\AT4G00467

2 of 13

Yes

Atha\AT4G34150

2 of 13

Yes

Atha\AT5G37740

2 of 13

Yes

Atha\C2

2 of 13

Yes

Atha\EHB1

2 of 13

Yes

Atha\ZAC

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (8)

Scer\TCB3

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Scer\PEX28

1 of 13

Yes

Scer\TCB1

1 of 13

Scer\TCB2

1 of 13

Schizosaccharomyces pombe (Fission yeast) (4)

Spom\syn1

2 of 12

Yes

Spom\fic1

1 of 12

Yes

Spom\mug190

1 of 12

Spom\SPCC962.01

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Mctp. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (16)

Pkc53E

2 of 13

Rph

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Git

1 of 13

Nedd4

1 of 13

RasGAP1

1 of 13

raskol

1 of 13

vap

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MCTP1; multiple C2 and transmembrane domain containing 1

14 of 14

616296

MCTP2; multiple C2 and transmembrane domain containing 2

13 of 14

616297

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

62835

DroID - A comprehensive database of gene and protein interactions.

FBgn0034389

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-86

Cytogenetic map

55F1-55F2

Sequence location

2R:18,761,758..18,774,824 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

55F1-55F2

Limits computationally determined from genome sequence between P{EP}EP437 and P{PZ}l(2)03709⁰³⁷⁰⁹

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-86

(FlyBase, 2016)

2-91.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

17855

w¹¹¹⁸; PBac{RB}Mctp^e00415

36257

y¹ w^*; Mi{MIC}Mctp^MI02901

59726

y¹ w^*; Mi{MIC}Mctp^MI14773

76765

y¹ w^*; Mi{Trojan-GAL4.1}Mctp^{MI14773-TG4.1}/SM6a

NIG-Fly

15078R-2

P{NIG.15078R}2

2RG-1465

y² VhaAC39-1^cho-1 v¹; P{U6-Mctp.NIG.sgRNA}attP40/CyO

VDRC

v100312

P{KK104930}VIE-260B

v103778

P{KK102643}VIE-260B

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (16)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_RE18318

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0034389

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

GM06083

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0034389

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG33148 CG33146

(Shin et al., 2005)

Additional comments

Annotations CG33146 and CG33148 merged as CG15078 (which corresponds to Mctp) in release 5.1 of the genome annotation.

(FlyBase Genome Annotators, 2006)

Annotation CG15078 split into CG33146, CG33148 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Source for identity of: Mctp CG33148 CG33146

(Shin et al., 2005)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CG15078

(National Institute of Genetics Fly Stocks, 2022-, Honjo et al., 2016, Keleman et al., 2009.8.5, FlyBase Genome Annotators, 2006)

CG33146

(Shin et al., 2005, Giot et al., 2003)

CG33148

(Shin et al., 2005)

DmMCTP

(Shin et al., 2005)

Mctp

(Praschberger et al., 2023, Navarro-Dominguez et al., 2022, Scholz et al., 2019, Chen et al., 2016, Gene Disruption Project members, 2016-, Honjo et al., 2016, Japanese National Institute of Genetics, 2012.5.21, Tunstall et al., 2012, Jungreis et al., 2011, Gan et al., 2010, Kong et al., 2010)

mctp

(Frank et al., 2020, Genç et al., 2017)

Name Synonyms

Multiple C2 domain and transmembrane region protein

(Shin et al., 2005)

Secondary FlyBase IDs

FBan0033146
FBgn0053146
FBgn0053148

Datasets (0)

Study focus (0)

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External Crossreferences and Linkouts ( 48 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37165

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A1ZBD6

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

A1ZBD6

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q7JZN2

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A1ZBD6

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0034389

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37165/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0034389

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0034389

FlyMine - An integrated database for Drosophila genomics

FBgn0034389

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG15078

MARRVEL_MODEL - MARRVEL (model organism gene)

37165

Linkouts

BioGRID - A database of protein and genetic interactions.

62835

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0034389

DroID - A comprehensive database of gene and protein interactions.

FBgn0034389

DRSC - Results frm RNAi screens

FBgn0034389

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0034389

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0034389

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG33146

Flygut - An atlas of the Drosophila adult midgut

FBgn0034389

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014537

References (41)

The following external sites may use different assemblies or annotations than FlyBase.

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