FlyBase Gene Report: Dmel\Tmx2

General Information

Symbol

Dmel\Tmx2

Species

D. melanogaster

Name

Thioredoxin related transmembrane protein 2

Annotation Symbol

CG11007

Feature Type

protein_coding_gene

FlyBase ID

FBgn0034455

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

56D14-56D14

Sequence location

2R:19,503,068..19,504,594 [+]

Recombination map

2-89

RefSeq locus

NT_033778 REGION:19503068..19504594

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables disulfide oxidoreductase activity

inferred from biological aspect of ancestor with PANTHER:PTN000406896

(GO Reference Genome Project, 2011-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of mitochondrion organization

inferred from sequence or structural similarity with UniProtKB:Q9Y320

(Chen et al., 2025)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in endoplasmic reticulum membrane

inferred from biological aspect of ancestor with PANTHER:PTN001040199

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with UniProtKB:Q9Y320

(Chen et al., 2025)

is_active_in mitochondria-associated endoplasmic reticulum membrane contact site

inferred from sequence or structural similarity with UniProtKB:Q9Y320

(Chen et al., 2025)

inferred from biological aspect of ancestor with PANTHER:PTN001040199

(GO Reference Genome Project, 2011-)

is_active_in mitochondrion

inferred from biological aspect of ancestor with PANTHER:PTN001040199

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

UNCLASSIFIED SULFUR GROUP OXIDOREDUCTASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

UNCLASSIFIED SULFUR GROUP OXIDOREDUCTASES -: This group comprises sulfur group oxidoreductases that do not classify under other groups in FlyBase.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Tmx2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7JW12)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Tmx2-RA

FBtr0086464

NM_137585

1201

271

Tmx2-RB

FBtr0345929

NM_001299688

1527

271

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Tmx2-PA

FBpp0085660

31.3

271

9.24

FBpp0311843

31.3

271

9.24

Q7JW12

NP_001286617

AHN56412

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

271 aa isoforms: Tmx2-PA, Tmx2-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Domain

The thioredoxin domain lacks the 2 redox-active cysteines, suggesting that it lacks thioredoxin activity.

The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

(UniProt, Q7JW12)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tmx2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG11007_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.70

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

Comment: rapidly degraded

(Fisher et al., 2012)

embryonic stage 7 -- 8

head mesoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

central brain primordium

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

central brain primordium

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

larval visceral muscle cell

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Tmx2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Tmx2

View exonic expression by tissue for Dmel\Tmx2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0034455

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37249/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0034455

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0034455

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0034455

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11007

Flygut - An atlas of the Drosophila adult midgut

FBgn0034455

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Tmx2

Transgenic constructs containing regulatory region of Tmx2

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal, with Scer\GAL4^repo

Tmx2^GD2093

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Tmx2^GD2093

viable, with Scer\GAL4^Mef2.PR

Tmx2^GD2093

viable, with Scer\GAL4^nSyb.PS

Tmx2^GD2093

viable, with Scer\GAL4^pnr-MD237

Tmx2^GD2093

viable, with Scer\GAL4^tin.CΔ4

Tmx2^GD2093

Other Phenotypes

Allele

bang sensitive | progressive, with Scer\GAL4^repo

Tmx2^GD2093

decreased rate of adult locomotory behavior | progressive, with Scer\GAL4^repo

Tmx2^GD2093

short lived, with Scer\GAL4^repo

Tmx2^GD2093

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (9)

Hsap\TMX2

14 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\TMX3

1 of 14

Hsap\TXNDC5

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (4)

Rnor\Tmx2

14 of 14

Yes

Rnor\Dnajc10

1 of 14

Rnor\Erp44

1 of 14

Rnor\Glrx3

1 of 14

Mus musculus (laboratory mouse) (5)

Mmus\Tmx2

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (3)

Xtro\tmx2

11 of 13

Yes

Xtro\glrx3

1 of 13

Xtro\txndc5

1 of 13

Danio rerio (Zebrafish) (10)

Drer\tmx2b

14 of 14

Yes

Drer\tmx2a

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (9)

Cele\C35D10.10

14 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (6)

Agam\AgaP_AGAP009997

12 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (5)

Atha\AT5G11640

9 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\TRX1

1 of 13

Yes

Scer\TRX2

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPAC17H9.14c

1 of 12

Yes

Escherichia coli (enterobacterium) (2)

Ecol\trxA

1 of 11

Yes

Ecol\trxC

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Tmx2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (3)

CaBP1

1 of 13

dhd

1 of 13

Grx3

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

TMX2; thioredoxin related transmembrane protein 2

14 of 14

616715

NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, CORTICAL MALFORMATIONS, AND SPASTICITY; NEDMCMS

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Tmx2 - strat

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

62907

DroID - A comprehensive database of gene and protein interactions.

FBgn0034455

MIST (protein-protein) - An integrated Molecular Interaction Database

37249

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-89

Cytogenetic map

56D14-56D14

Sequence location

2R:19,503,068..19,504,594 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

56D14-56D14

Limits computationally determined from genome sequence between P{lacW}l(2)k00705^k00705&P{lacW}mei-W68^k05603 and P{EP}CG11007^EP736

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-89

(FlyBase, 2016)

2-94.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

17196

w¹¹¹⁸; P{EP}Tmx2^EP736/CyO

602323

y¹ w^*; TI{KozakGAL4}Tmx2^{CR71069-KO-kG4}/SM6a

Kyoto

114459

y^d2 w¹¹¹⁸ P{ey-FLP.N}2; P{neoFRT}42D P{EP}Tmx2^EP736 /CyO y⁺

NIG-Fly

11007R-1

P{NIG.11007R}1

2RG-0144

y² VhaAC39-1^cho-1 v¹; P{U6-Tmx2.NIG.sgRNA}attP40/CyO

VDRC

v40833

w¹¹¹⁸; P{GD2093}v40833

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (45)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD01519

Other clones

DPiM_LD01519

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0034455

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0034455

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Tmx2 CG11007

(Chen et al., 2025)

Nomenclature comments

Etymology

The gene is named 'Tmx2' based on the closest human ortholog.

(Chen et al., 2025)

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CG11007

(Chen et al., 2025, Burghardt et al., 2023, National Institute of Genetics Fly Stocks, 2022-, Gene Disruption Project members, 2018-, Çiçek et al., 2016, Luck et al., 2014, Kwon et al., 2013, Japanese National Institute of Genetics, 2012.5.21)

TMX2

(Chen et al., 2025)

Tmx2

Name Synonyms

Thioredoxin related transmembrane protein 2

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 37 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37249

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7JW12

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q7JW12

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0B4LFY2

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7JW12

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0034455

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37249/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0034455

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0034455

FlyMine - An integrated database for Drosophila genomics

FBgn0034455

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG11007

MARRVEL_MODEL - MARRVEL (model organism gene)

37249

Linkouts

BioGRID - A database of protein and genetic interactions.

62907

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0034455

DroID - A comprehensive database of gene and protein interactions.

FBgn0034455

DRSC - Results frm RNAi screens

FBgn0034455

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG11007_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0034455

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0034455

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11007

Flygut - An atlas of the Drosophila adult midgut

FBgn0034455

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC015732

MIST (protein-protein) - An integrated Molecular Interaction Database

37249

References (31)

The following external sites may use different assemblies or annotations than FlyBase.

4.70

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