FlyBase Gene Report: Dmel\nolo

General Information

Symbol

Dmel\nolo

Species

D. melanogaster

Name

no long nerve cord

Annotation Symbol

CG31619

Feature Type

protein_coding_gene

FlyBase ID

FBgn0051619

Gene Model Status

Current

Stock Availability

19 publicly available

Gene Summary

no long nerve cord (nolo) encodes a protein involved in ventral cord development. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

CT6940

Key Links

Genomic Location

Cytogenetic map

39F1-39F3

Sequence location

2L:21,684,106..21,729,051 [+]

Recombination map

2-54

RefSeq locus

NT_033779 REGION:21684106..21729051

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (2 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in ventral cord development

inferred from mutant phenotype

(Meyer et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in extracellular matrix organization

inferred from electronic annotation with InterPro:IPR013273

(InterPro Project Members, 2004-)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

ADAMTS LIKE

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

no long nerve cord (nolo) encodes a protein involved in ventral cord development. [Date last reviewed: 2019-09-12]

Gene Group (FlyBase)

ADAMTS LIKE -: ADAMTS-like proteins contain ADAMTS ancillary domains but they lack the catalytic domain and therefore lack proteolytic activity. ADAMTS-like proteins appear to have regulatory roles in the extracellular matrix, perhaps regulating ADAMTS proteins. (Adapted from PMID:19734141.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\nolo for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q0E8N3)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.49

Multiphase exon postulated: exon reading frame differs in alternative transcripts; overlap >20aa.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

nolo-RA

FBtr0085901

NM_165396

5565

1353

nolo-RB

FBtr0085902

NM_165397

3610

1014

nolo-RC

FBtr0110959

NM_001042909

5495

1394

nolo-RD

FBtr0301000

NM_001169569

5477

1388

nolo-RE

FBtr0307497

NM_001259199

5688

1394

nolo-RF

FBtr0339131

NM_001299197

5180

1208

nolo-RG

FBtr0339132

NM_001299198

5351

1346

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

nolo-PA

FBpp0085256

150.2

1353

6.51

FBpp0085257

112.2

1014

5.90

FBpp0110259

154.6

1394

6.55

FBpp0290222

153.9

1388

6.55

FBpp0298832

154.6

1394

6.55

FBpp0308276

133.4

1208

5.83

FBpp0308277

149.5

1346

6.51

X2JAM1

NP_001286127

AHN54641

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1394 aa isoforms: nolo-PC, nolo-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nolo using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG31619_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.52

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 12

larval foregut atrium | precursor

Comment: reported as atrium primordium

(Fisher et al., 2012)

Bolwig organ primordium

Comment: reported as larval eye primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{Switch2}nolo^GSG1802-2

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

larval neuron | subset of larval ventral nerve cord

(Nicholson et al., 2008)

VL fascicle

(Nicholson et al., 2008)

motor neuron

• neuromuscular junction

(Nicholson et al., 2008)

embryonic/larval hypodermal muscle cell

• neuromuscular junction

(Nicholson et al., 2008)

embryonic/larval neuromuscular junction

• type Ib terminal bouton

(Nicholson et al., 2008)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\nolo in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\nolo

View exonic expression by tissue for Dmel\nolo

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0051619

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35424/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0051619

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0051619

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0051619

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31619

Flygut - An atlas of the Drosophila adult midgut

FBgn0051619

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\nolo

Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 21 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of nolo

Transgenic constructs containing regulatory region of nolo

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2L)Exel7082

(Ryder, 2004.4.26)

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

nolo^GSG1802-2

partially lethal, with Scer\GAL4^wor.PA

nolo^HMC03983

partially lethal, with Scer\GAL4^wor.PA, nolo^HMC03983

nolo^ΔA23

partially lethal, with Scer\GAL4^wor.PA, nolo^ΔA23

nolo^HMC03983

partially lethal, with Scer\GAL4^αTub84B.PL

nolo^HMC03983

partially lethal, with Scer\GAL4^αTub84B.PL, nolo^HMC03983

nolo^ΔA23

partially lethal, with Scer\GAL4^αTub84B.PL, nolo^ΔA23

nolo^HMC03983

partially lethal, with Scer\GAL4^αTub84B.PL, Scer\GAL4^wor.PA, Spyo\Cas9^nanos.cPa

nolo^WKO.3-B3

partially lethal - majority die, with Scer\GAL4^pnr-MD237

nolo^GD491

partially lethal - majority die | maternal effect

nolo^Δ4-12

viable

nolo^Δ4-12

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

nolo^GD491

viable, with Scer\GAL4^tin.CΔ4

nolo^GD491

Other Phenotypes

Allele

abnormal behavior | larval stage

nolo^Δ4-12

abnormal locomotor behavior | larval stage

nolo^Δ4-12

abnormal neuroanatomy | larval stage

nolo^ΔA23

abnormal neuroanatomy | larval stage, with Scer\GAL4^unspecified

nolo^HMC03983

abnormal neuroanatomy | larval stage, with Scer\GAL4^αTub84B.PL, Scer\GAL4^wor.PA, Spyo\Cas9^nanos.cPa

nolo^WKO.3-B3

flightless

nolo^Δ4-12

some die during P-stage, with Scer\GAL4^wor.PA

nolo^HMC03983

some die during P-stage, with Scer\GAL4^wor.PA, nolo^HMC03983

nolo^ΔA23

some die during P-stage, with Scer\GAL4^wor.PA, nolo^ΔA23

nolo^HMC03983

some die during P-stage, with Scer\GAL4^αTub84B.PL

nolo^HMC03983

some die during P-stage, with Scer\GAL4^αTub84B.PL, nolo^HMC03983

nolo^ΔA23

some die during P-stage, with Scer\GAL4^αTub84B.PL, nolo^ΔA23

nolo^HMC03983

some die during P-stage, with Scer\GAL4^αTub84B.PL, Scer\GAL4^wor.PA, Spyo\Cas9^nanos.cPa

nolo^WKO.3-B3

some die during pupal stage, with Scer\GAL4^pnr-MD237

nolo^GD491

visible, with Scer\GAL4^pnr-MD237

nolo^GD491

Phenotype manifest in

Allele

embryonic/larval neuromuscular junction | larval stage

nolo^ΔA23

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^unspecified

nolo^HMC03983

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^αTub84B.PL, Scer\GAL4^wor.PA, Spyo\Cas9^nanos.cPa

nolo^WKO.3-B3

mesonotum, with Scer\GAL4^pnr-MD237

nolo^GD491

NMJ bouton | decreased number | larval stage

nolo^ΔA23

NMJ bouton | decreased number | larval stage, with Scer\GAL4^unspecified

nolo^HMC03983

NMJ bouton | decreased number | larval stage, with Scer\GAL4^αTub84B.PL, Scer\GAL4^wor.PA, Spyo\Cas9^nanos.cPa

nolo^WKO.3-B3

wing

nolo^Δ4-12

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (44)

Hsap\ADAMTSL1

10 of 14

Yes

Hsap\ADAMTSL3

10 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Hsap\ADAMTSL4

2 of 14

Hsap\ADAMTSL5

2 of 14

Hsap\ADGRB1

2 of 14

Yes

Hsap\PAPLN

2 of 14

Hsap\THSD4

2 of 14

Hsap\THSD7A

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (30)

Rnor\Adamtsl3

10 of 14

Yes

Rnor\Adamtsl1

9 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (34)

Mmus\Adamtsl1

10 of 14

Yes

Mmus\Adamtsl3

10 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Hmcn1

1 of 14

Mmus\Sema5b

1 of 14

Mmus\Thsd1

1 of 14

Yes

Mmus\Thsd4

1 of 14

Mmus\Thsd7b

1 of 14

Yes

Mmus\Wfikkn2

1 of 14

Xenopus tropicalis (Western clawed frog) (36)

Xtro\adamtsl1

8 of 13

Yes

Xtro\adamtsl3

8 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\traf7

1 of 13

Yes

Xtro\ubxn2a

1 of 13

Danio rerio (Zebrafish) (38)

Drer\adamtsl3

9 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\adamtsl5

1 of 14

Drer\cilp

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:ch211-267e7.3

1 of 14

Drer\si:dkeyp-73b11.8

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\thsd7ba

1 of 14

Yes

Drer\wfikkn2a

1 of 14

Drer\wfikkn2b

1 of 14

Drer\wu:fb59d01

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (30)

Cele\madd-4

11 of 14

Yes

Cele\adt-1

2 of 14

Cele\adt-3

2 of 14

Cele\T21B6.3

2 of 14

Yes

Cele\adt-2

1 of 14

Cele\C27A7.8

1 of 14

Yes

Cele\C27A7.9

1 of 14

Yes

Cele\C36B7.5

1 of 14

Cele\C55C3.7

1 of 14

Yes

Cele\dpy-31

1 of 14

Cele\F02H6.6

1 of 14

Yes

Cele\F02H6.7

1 of 14

Yes

Cele\F11C7.6

1 of 14

Yes

Cele\F11C7.7

1 of 14

Yes

Cele\F14H12.3

1 of 14

Yes

Cele\F35C11.7

1 of 14

Yes

Cele\F58F9.6

1 of 14

Yes

Cele\F58F9.8

1 of 14

Yes

Cele\F58F9.9

1 of 14

Yes

Cele\fig-1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\Y8A9A.2

1 of 14

Yes

Cele\Y46D2A.3

1 of 14

Yes

Cele\Y64G10A.1

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (9)

Agam\AgaP_AGAP007792

12 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

Agam\AgaP_AGAP002424

1 of 12

Agam\AgaP_AGAP010003

1 of 12

Agam\AgaP_AGAP011737

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:nolo. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (9)

AdamTS-A

3 of 13

AdamTS-B

3 of 13

Ppn

3 of 13

stl

3 of 13

sona

2 of 13

CG31609

1 of 13

loh

1 of 13

Sema5c

1 of 13

unc-5

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ADAMTSL1; ADAMTS like 1

10 of 14

609198

ADAMTSL3; ADAMTS like 3

10 of 14

609199

ADAMTS6; ADAM metallopeptidase with thrombospondin type 1 motif 6

3 of 14

605008

ADAMTS8; ADAM metallopeptidase with thrombospondin type 1 motif 8

3 of 14

605175

ADAMTS9; ADAM metallopeptidase with thrombospondin type 1 motif 9

3 of 14

605421

ADAMTS19; ADAM metallopeptidase with thrombospondin type 1 motif 19

3 of 14

607513

CARDIAC VALVULAR DYSPLASIA 2; CVDP2

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

nolo - Drep2

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

nolo

enhanceable

Oatp30B

(Meyer et al., 2014)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

61368

DroID - A comprehensive database of gene and protein interactions.

FBgn0051619

MIST (protein-protein) - An integrated Molecular Interaction Database

35424

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

O-glycosylation of TSR domain-containing proteins

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-54

Cytogenetic map

39F1-39F3

Sequence location

2L:21,684,106..21,729,051 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

39F1-39F3

Limits computationally determined from genome sequence between P{lacW}Df31^k05815 and P{PZ}cul-2⁰²⁰⁷⁴&P{lacW}l(2)k08110^k08110

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-54

(FlyBase, 2016)

2-54.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (19)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

83042

y¹; M{WKO.3-B3}ZH-86Fb

74400

w¹¹¹⁸; P{VT011075-p65.AD}attP40

75492

w¹¹¹⁸; P{VT011075-GAL4.DBD}attP2

55296

y¹ v¹; P{TRiP.HMC03983}attP2

40987

w^*; P{Switch2}nolo^GSG1802-2/CyO

56418

y¹ w^*; Mi{MIC}nolo^MI11393

34291

y¹ w^*; Mi{MIC}nolo^MI02195/SM6a

53118

y¹ w^*; Mi{MIC}nolo^MI09505/SM6a

12909

y¹ w^67c23; P{SUPor-P}nolo^KG02868

Korea

13397

P{VT011075-GAL4}attP2

VDRC

v104736

P{KK103748}VIE-260B

v33102

w¹¹¹⁸; P{GD491}v33102

More stocks available...

Genomic Clones (24)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (58)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

RT01718

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0051619

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0051619

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: CG2131 CG2122

(FlyBase, 1996-)

Source for merge of: CG13236 CG2131

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Annotations CG13236, CG2122 and CG2131 merged as CG31619 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of CG2131 CG2122 was a shared cDNA ( date:010720 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: nolo CG31619

(Meyer et al., 2014)

Nomenclature comments

Etymology

Named 'no long nerve cord' because the length of the ventral nerve cord is not extended in mutants, whereas initial experiments using RNAi to knock-down expression of the gene id produce this phenotype.

(Meyer et al., 2014)

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CG13236

CG2122

CG2131

(Fujii and Amrein, 2002)

CG31619

(National Institute of Genetics Fly Stocks, 2022-, Gene Disruption Project members, 2015-, Hosono et al., 2015, Rosa-Ferreira et al., 2015, Andlauer et al., 2014, Ashwal-Fluss et al., 2014, Meyer et al., 2014, Sing et al., 2014, Ozkan et al., 2013, Cole et al., 2012.7.6, Rodriguez et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Nicholson et al., 2008, Badal et al., 2006)

CT6940

(Hynes and Zhao, 2000, Hynes and Zhao, 2000)

no long nerve cord

(Frantz et al., 2023)

nolo

(Mohana et al., 2023, National Institute of Genetics Fly Stocks, 2022-, Velten et al., 2022, McLaughlin et al., 2021, He et al., 2019, Meltzer et al., 2019, Gene Disruption Project members, 2016-, Meyer et al., 2014)

Name Synonyms

no long nerve cord

Secondary FlyBase IDs

FBgn0032958
FBgn0032959
FBgn0040517

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 77 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35424

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q0E8N3

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q0E8N3

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0051619

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35424/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0051619

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0051619

FlyMine - An integrated database for Drosophila genomics

FBgn0051619

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG31619

MARRVEL_MODEL - MARRVEL (model organism gene)

35424

Linkouts

BioGRID - A database of protein and genetic interactions.

61368

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0051619

DroID - A comprehensive database of gene and protein interactions.

FBgn0051619

DRSC - Results frm RNAi screens

FBgn0051619

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG31619_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0051619

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0051619

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31619

Flygut - An atlas of the Drosophila adult midgut

FBgn0051619

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0051619

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC033768

MIST (protein-protein) - An integrated Molecular Interaction Database

35424

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

O-glycosylation of TSR domain-containing proteins

References (60)

The following external sites may use different assemblies or annotations than FlyBase.

-0.52

Report Sections