FlyBase Gene Report: Dmel\SPoCk

General Information

Symbol

Dmel\SPoCk

Species

D. melanogaster

Name

Secretory Pathway Calcium atpase

Annotation Symbol

CG32451

Feature Type

protein_coding_gene

FlyBase ID

FBgn0052451

Gene Model Status

Current

Stock Availability

17 publicly available

Enzyme Name (EC)

P-type Ca(2+) transporter (7.2.2.10)

Gene Summary

Secretory Pathway Calcium atpase (SPoCk) encodes a transporting ATPase with roles in the maintenance of cellular Ca2+ homeostasis. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

80A1-80A2

Sequence location

3L:22,749,444..22,787,631 [+]

Recombination map

3-47

RefSeq locus

NT_037436 REGION:22749444..22787631

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (19 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables P-type calcium transporter activity

inferred from mutant phenotype

(Southall et al., 2006)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR001757

(InterPro Project Members, 2004-)

enables ATP hydrolysis activity

inferred from electronic annotation with InterPro:IPR001757

(InterPro Project Members, 2004-)

enables nucleotide binding

inferred from electronic annotation with InterPro:IPR023299

(InterPro Project Members, 2004-)

enables P-type calcium transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN002450634

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with UniProtKB:P13586

(Southall et al., 2006)

inferred from electronic annotation with InterPro:IPR006413

(InterPro Project Members, 2004-)

enables P-type manganese transporter activity

inferred from sequence or structural similarity with UniProtKB:P13586

(Southall et al., 2006)

Biological Process (7 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in calcium ion transmembrane transport

inferred from mutant phenotype

(Southall et al., 2006)

involved_in calcium ion transport from cytosol to endoplasmic reticulum

inferred from mutant phenotype

(Southall et al., 2006)

involved_in Golgi calcium ion transmembrane transport

inferred from mutant phenotype

(Southall et al., 2006)

involved_in intracellular calcium ion homeostasis

inferred from mutant phenotype

(Southall et al., 2006)

involved_in peroxisomal membrane transport

inferred from mutant phenotype

(Southall et al., 2006)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in calcium ion transmembrane transport

inferred from biological aspect of ancestor with PANTHER:PTN002450634

(GO Reference Genome Project, 2011-)

involved_in calcium ion transport

inferred from electronic annotation with InterPro:IPR006413

(InterPro Project Members, 2004-)

involved_in intracellular calcium ion homeostasis

inferred from biological aspect of ancestor with PANTHER:PTN002450634

(GO Reference Genome Project, 2011-)

involved_in manganese ion transport

inferred from biological aspect of ancestor with PANTHER:PTN000643689

(GO Reference Genome Project, 2011-)

Cellular Component (7 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in endomembrane system

inferred from high throughput direct assay

(Tan et al., 2009)

located_in endoplasmic reticulum membrane

inferred from direct assay

(Southall et al., 2006)

located_in Golgi membrane

inferred from direct assay

(Southall et al., 2006)

located_in peroxisomal membrane

inferred from direct assay

(Southall et al., 2006)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

is_active_in endoplasmic reticulum

inferred from biological aspect of ancestor with PANTHER:PTN000643689

(GO Reference Genome Project, 2011-)

is_active_in Golgi membrane

inferred from biological aspect of ancestor with PANTHER:PTN000643691

(GO Reference Genome Project, 2011-)

located_in membrane

inferred from electronic annotation with InterPro:IPR001757, InterPro:IPR006413

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000643689

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

SARCO(ENDO)PLASMIC RETICULUM CALCIUM TRANSPORTING P-ATPASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

ATP hydrolysis activity
RHEA 13065: P-type calcium transporter activity

Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+) (7.2.2.10)

RHEA 18105: P-type manganese transporter activity
RHEA 66820:

Summaries

Gene Snapshot

Secretory Pathway Calcium atpase (SPoCk) encodes a transporting ATPase with roles in the maintenance of cellular Ca2+ homeostasis. [Date last reviewed: 2019-09-12]

Gene Group (FlyBase)

SARCO(ENDO)PLASMIC RETICULUM CALCIUM TRANSPORTING P-ATPASES -: Sarco(endo)plasmic reticulum Ca²⁺ transporting ATPases (SERCA) are type IIA P-ATPases that utilize the hydrolysis of ATP to drive the transmembrane transport of Ca²⁺ from the cytoplasm to the lumen of organelle. (Adapted from FBrf0224947.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\SPoCk for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry M9PG15)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 6.25

Gene model reviewed during 5.45

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Gene model reviewed during 5.56

Stop-codon suppression (UGA) postulated; FBrf0234051.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

SPoCk-RA

FBtr0078531

NM_168963

3659

901

SPoCk-RB

FBtr0078533

NM_168961

5916

1034

SPoCk-RC

FBtr0078532

NM_168962

3716

924

SPoCk-RD

FBtr0113437

NM_001104196

3742

997

SPoCk-RE

FBtr0302134

NM_001170025

4245

917

SPoCk-RF

FBtr0306600

NM_001259958

4059

917

SPoCk-RG

FBtr0332105

NM_001275291

3937

1062

SPoCk-RH

FBtr0474170

NM_001370004

3659

916

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

SPoCk-PA

FBpp0078183

99.5

901

6.52

FBpp0078185

113.8

1034

5.67

FBpp0078184

102.2

924

6.52

FBpp0112349

109.9

997

7.50

FBpp0291344

101.2

917

6.30

FBpp0297555

101.2

917

6.30

FBpp0304415

116.7

1062

7.46

FBpp0423169

101.2

916

6.47

QCD26228

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

917 aa isoforms: SPoCk-PE, SPoCk-PF

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SPoCk using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.84

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in endomembrane system

inferred from high throughput direct assay

(Tan et al., 2009)

located_in endoplasmic reticulum membrane

inferred from direct assay

(Southall et al., 2006)

located_in Golgi membrane

inferred from direct assay

(Southall et al., 2006)

located_in peroxisomal membrane

inferred from direct assay

(Southall et al., 2006)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\SPoCk in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\SPoCk

View exonic expression by tissue for Dmel\SPoCk

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0052451

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40495/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0052451

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052451

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0052451

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32451

Flygut - An atlas of the Drosophila adult midgut

FBgn0052451

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 20 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of SPoCk

Transgenic constructs containing regulatory region of SPoCk

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

SPoCk^GD12766

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

SPoCk^GD12766

Phenotype manifest in

Allele

Malpighian tubule, with Scer\GAL4^c42

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (23)

Hsap\ATP2C1

14 of 14

Yes

Hsap\ATP2C2

13 of 14

Yes

7 of 14

7 of 14

6 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (21)

Rnor\Atp2c1

14 of 14

Yes

Rnor\Atp2c2

13 of 14

Yes

7 of 14

5 of 14

5 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (21)

Mmus\Atp2c1

14 of 14

Yes

Mmus\Atp2c2

13 of 14

Yes

7 of 14

7 of 14

6 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (27)

Xtro\atp2c1

11 of 13

Yes

Xtro\atp2c2

10 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\zbtb7c

1 of 13

Yes

Danio rerio (Zebrafish) (26)

Drer\atp2c1

14 of 14

Yes

7 of 14

7 of 14

7 of 14

7 of 14

6 of 14

5 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (15)

Cele\pmr-1

13 of 14

Yes

5 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (7)

Agam\AgaP_AGAP012115

12 of 12

Yes

4 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (32)

Atha\ECA1

7 of 13

Yes

Atha\ECA2

7 of 13

Yes

Atha\ECA4

7 of 13

Yes

6 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Yes

Atha\AT4G11730

1 of 13

Yes

Atha\HA1

1 of 13

Yes

Atha\HA2

1 of 13

Yes

Atha\HA3

1 of 13

Yes

Atha\HA4

1 of 13

Yes

Atha\HA5

1 of 13

Yes

Atha\HA6

1 of 13

Yes

Atha\HA7

1 of 13

Yes

Atha\HA8

1 of 13

Yes

Atha\HA9

1 of 13

Yes

Atha\HA11

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (10)

Scer\PMR1

13 of 13

Yes

4 of 13

4 of 13

4 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (8)

Spom\pmr1

12 of 12

Yes

4 of 12

1 of 12

1 of 12

1 of 12

Yes

Spom\pma2

1 of 12

Yes

Spom\SPAPB2B4.04c

1 of 12

Spom\SPCC1672.11c

1 of 12

Escherichia coli (enterobacterium) (2)

Ecol\mgtA

3 of 11

Yes

Ecol\kdpB

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:SPoCk. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (10)

9 of 13

4 of 13

4 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

ATP2C1; ATPase secretory pathway Ca2+ transporting 1

model of Hailey-Hailey disease

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

SPoCk^NIG.32451R

exacerbates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\poly-GR^PO-36.UAS

(Park et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ATP2C1; ATPase secretory pathway Ca2+ transporting 1

14 of 14

604384

HAILEY-HAILEY DISEASE; HHD

Hailey-Hailey disease

ATP2C2; ATPase secretory pathway Ca2+ transporting 2

13 of 14

613082

ATP2A1; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

7 of 14

108730

BRODY DISEASE; BROD

Brody myopathy

ATP2A2; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

7 of 14

108740

ATP2A3; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

6 of 14

601929

ATP1A1; ATPase Na+/K+ transporting subunit alpha 1

3 of 14

182310

Charcot-Marie-Tooth disease type 2DD

ATP1A2; ATPase Na+/K+ transporting subunit alpha 2

3 of 14

182340

ATP1A4; ATPase Na+/K+ transporting subunit alpha 4

3 of 14

607321

ATP2B1; ATPase plasma membrane Ca2+ transporting 1

3 of 14

108731

INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL DOMINANT 66; MRD66

autosomal dominant intellectual developmental disorder 66

ATP2B2; ATPase plasma membrane Ca2+ transporting 2

3 of 14

108733

DEAFNESS, AUTOSOMAL DOMINANT 82; DFNA82

autosomal dominant nonsyndromic deafness 82

ATP2B3; ATPase plasma membrane Ca2+ transporting 3

3 of 14

300014

SPINOCEREBELLAR ATAXIA, X-LINKED 1; SCAX1

X-linked spinocerebellar ataxia 1

ATP4A; ATPase H+/K+ transporting subunit alpha

3 of 14

137216

ATP12A; ATPase H+/K+ transporting non-gastric alpha2 subunit

3 of 14

182360

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

65727

DroID - A comprehensive database of gene and protein interactions.

FBgn0052451

MIST (protein-protein) - An integrated Molecular Interaction Database

40495

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Ion transport by P-type ATPases

Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2016)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47

Cytogenetic map

80A1-80A2

Sequence location

3L:22,749,444..22,787,631 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

80A1-80A2

Limits computationally determined from genome sequence between P{lacW}l(3)j1B10^j1B10 and P{lacW}l(3)j2C4^j2C4

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-47

(FlyBase, 2016)

3-44.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (17)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

28352

y¹ v¹; P{TRiP.JF02988}attP2

65722

w¹¹¹⁸; PBac{IT.GAL4}SPoCk^2119-G4

34444

y¹ w^*; Mi{MIC}SPoCk^MI01547

58638

y¹ w^*; Mi{MIC}SPoCk^MI12413

15848

y¹ w^67c23; P{EPgy2}SPoCk^EY02005

76472

y¹ sc^* v¹ sev²¹; P{TKO.GS00648}attP40

79673

y¹ sc^* v¹ sev²¹; P{TOE.GS01261}attP40

44040

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02756}attP40

Korea

11115

P{EP}SPoCk^G9333

Kyoto

104076

w^*; P{GawB}SPoCk^NP2070 / TM3, Sb¹ Ser¹

VDRC

v110379

P{KK101068}VIE-260B

v22975

w¹¹¹⁸; P{GD12766}v22975

More stocks available...

Genomic Clones (35)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (77)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RH03344

Other clones

MIP02852

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0052451

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0052451

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Area matching Drosophila EST AA202880 (inverted). This EST has sequence similarity to Calcium ATPase genes.

(Davies, 2001.3.15)

Relationship to Other Genes

Source for database merge of

Source for merge of: SPoCk anon-WO0118547.249

(FlyBase, 1996-)

Source for merge of: CG14449 CG7651

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Annotations CG14449 and CG7651 merged as CG32451 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of SPoCk anon-WO0118547.249 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: SPoCk CG32451

(Southall, 2005.3.3)

Nomenclature comments

Etymology

The gene is named "SPoCk" as it sits next to a gene called "Jim".

(Southall et al., 2006)

Named 'SPoCk' because it is a Secretory Pathway Calcium atpase, and it sits near to a gene called 'jim'.

(Southall, 2005.3.3)

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

ATP2C1/2

(Baron et al., 2016)

ATP2CD1

(Anderson-Baron and Simmonds, 2018)

CG14449

(Southall et al., 2006)

CG32451

(Anderson-Baron and Simmonds, 2018, Baron et al., 2016, Meadows, 2014.12.12, Faust et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Southall et al., 2006)

CG7651

(Southall et al., 2006)

SPoCK

(Anderson-Baron and Simmonds, 2018, Badal et al., 2006)

anon-WO0118547.249

sPoCk

(Pavlidaki et al., 2022)

Name Synonyms

Secretory Pathway Calcium atpase

(Southall, 2005.3.3)

Secretory pathway calcium atpase

(Anderson-Baron and Simmonds, 2018)

Secondary FlyBase IDs

FBgn0037189
FBgn0037190
FBgn0062145

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External Crossreferences and Linkouts ( 75 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40495

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

M9PG15

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

M9PG15

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0052451

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40495/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0052451

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0052451

FlyMine - An integrated database for Drosophila genomics

FBgn0052451

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG32451

MARRVEL_MODEL - MARRVEL (model organism gene)

40495

Linkouts

BioGRID - A database of protein and genetic interactions.

65727

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0052451

DroID - A comprehensive database of gene and protein interactions.

FBgn0052451

DRSC - Results frm RNAi screens

FBgn0052451

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052451

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0052451

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32451

Flygut - An atlas of the Drosophila adult midgut

FBgn0052451

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0052451

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC011526

MIST (protein-protein) - An integrated Molecular Interaction Database

40495

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Ion transport by P-type ATPases

References (75)

The following external sites may use different assemblies or annotations than FlyBase.

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