FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\AMPdeam
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General Information
Symbol
Dmel\AMPdeam
Species
D. melanogaster
Name
AMP deaminase
Annotation Symbol
CG32626
Feature Type
protein_coding_gene
FlyBase ID
FBgn0052626
Gene Model Status
Current
Stock Availability
17 publicly available
Enzyme Name (EC)
AMP deaminase (3.5.4.6)
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
12C6-12C7
Sequence location
Recombination map
1-46
RefSeq locus
NC_004354 REGION:13830741..13845866
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables AMP deaminase activity
inferred from biological aspect of ancestor with PANTHER:PTN000144579
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR006329
(InterPro Project Members, 2004-)
enables deaminase activity
inferred from electronic annotation with InterPro:IPR006650
(InterPro Project Members, 2004-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in AMP metabolic process
inferred from biological aspect of ancestor with PANTHER:PTN000144579
(GO Reference Genome Project, 2011-)
involved_in IMP biosynthetic process
inferred from biological aspect of ancestor with PANTHER:PTN000144579
(GO Reference Genome Project, 2011-)
involved_in IMP salvage
inferred from electronic annotation with InterPro:IPR006329
(InterPro Project Members, 2004-)
involved_in purine ribonucleoside monophosphate biosynthetic process
inferred from electronic annotation with InterPro:IPR006650
(InterPro Project Members, 2004-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
AMP deaminase activity
AMP + H2O + H(+) = IMP + NH4(+) (3.5.4.6)
RHEA 14777:
Summaries
Gene Group (FlyBase)
UNCLASSIFIED DEAMINASES -
This group comprises deaminases that do not classify under other groups in FlyBase.
UNCLASSIFIED CARBON-NITROGEN HYDROLASES OF CYCLIC AMIDINES -
This group comprises carbon-nitrogen hydrolases of cyclic amidines that do not classify under other groups in FlyBase.
Gene Model and Products
Number of Transcripts
9
Number of Unique Polypeptides
9

Please see the JBrowse view of Dmel\AMPdeam for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry X2JEY5)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.40

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.50

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
AMPdeam-RC
FBtr0073833
NM_132703
3216
707
AMPdeam-RE
FBtr0301044
NM_167384
2879
771
AMPdeam-RF
FBtr0301045
NM_167385
2814
649
AMPdeam-RG
FBtr0301046
NM_167386
2611
774
AMPdeam-RH
FBtr0303292
NM_001201659
2656
789
AMPdeam-RI
FBtr0309245
NM_001258730
4679
258
AMPdeam-RJ
FBtr0309246
NM_001258731
2620
777
AMPdeam-RK
FBtr0340444
NM_001298304
2810
798
AMPdeam-RL
FBtr0340445
NM_001298305
2647
786
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
AMPdeam-PC
FBpp0073664
82.0
707
6.03
Q961Q7
NP_572931
AAN09337
AMPdeam-PE
FBpp0290266
89.2
771
5.83
Q9VY76
NP_727739
AAF48329
AMPdeam-PF
FBpp0290267
75.8
649
6.39
Q76NQ9
NP_727740
AAF48331
AMPdeam-PG
FBpp0290268
89.4
774
5.91
Q76NR0
NP_727741
AAF48330
AMPdeam-PH
FBpp0292384
91.0
789
5.91
M9MS55
NP_001188588
ADV37670
AMPdeam-PI
FBpp0301184
29.1
258
4.94
M9NDW2
NP_001245659
AFH07373
AMPdeam-PJ
FBpp0301185
89.6
777
5.81
D0IQK3
NP_001245660
AFH07374
AMPdeam-PK
FBpp0309386
91.5
798
6.00
X2JEY5
NP_001285233
AHN59703
AMPdeam-PL
FBpp0309387
90.7
786
6.00
X2JFA0
NP_001285234
AHN59704
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\AMPdeam using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.49

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
Expression Deduced from Reporters
Reporter: PBac{602.P.SVS-1}AMPdeamCPTI001081
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain cell body rind
(Knowles-Barley, 2011.8.24)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\AMPdeam in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 15 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of AMPdeam
Transgenic constructs containing regulatory region of AMPdeam
Aberrations (Deficiencies and Duplications) ( 0 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (5)
Hsap\AMPD2
13 of 14
Yes
Yes
1  
Hsap\AMPD3
9 of 14
No
Yes
Hsap\AMPD1
8 of 14
No
Yes
Hsap\ADA2
1 of 14
No
No
1  
Hsap\ADA
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (5)
Rnor\Ampd2
13 of 14
Yes
Yes
Rnor\Ampd3
9 of 14
No
Yes
Rnor\Ampd1
8 of 14
No
Yes
Rnor\Adal
1 of 14
No
No
Rnor\Ada
1 of 14
No
No
Mus musculus (laboratory mouse) (5)
Mmus\Ampd2
13 of 14
Yes
Yes
Mmus\Ampd3
9 of 14
No
Yes
Mmus\Ampd1
7 of 14
No
Yes
Mmus\Adal
1 of 14
No
No
Mmus\Ada
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (6)
Xtro\ampd2
10 of 13
Yes
Yes
Xtro\ampd1
5 of 13
No
Yes
Xtro\ampd3
4 of 13
No
Yes
Xtro\hes6.2
1 of 13
No
No
Xtro\kif5a
1 of 13
No
No
Xtro\mphosph8
1 of 13
No
Yes
Danio rerio (Zebrafish) (9)
Drer\ampd2b
12 of 14
Yes
Yes
Drer\ampd2a
11 of 14
No
Yes
Drer\ampd3a
9 of 14
No
Yes
Drer\ampd3b
9 of 14
No
Yes
Drer\ampd1
8 of 14
No
Yes
Drer\ada2a
1 of 14
No
No
Drer\ada2b
1 of 14
No
No
Drer\ada
1 of 14
No
No
Drer\adal
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\ampd-1
13 of 14
Yes
Yes
Cele\adal-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (5)
Agam\AgaP_AGAP000577
11 of 12
Yes
Yes
Agam\AgaP_AGAP005158
1 of 12
No
No
Agam\AgaP_AGAP005283
1 of 12
No
No
Agam\AgaP_AGAP006906
1 of 12
No
No
Agam\AgaP_AGAP006907
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (2)
Atha\FAC1
12 of 13
Yes
Yes
Atha\AT4G04880
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\AMD1
13 of 13
Yes
Yes
Scer\YBR284W
4 of 13
No
Yes
Scer\YJL070C
4 of 13
No
Yes
Scer\AAH1
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\ada1
12 of 12
Yes
Yes
Spom\SPBC1683.02
2 of 12
No
No
Spom\dea2
1 of 12
No
No
Escherichia coli (enterobacterium) (1)
Ecol\add
1 of 11
Yes
No
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:AMPdeam. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (7)
Ada
1 of 13
Adgf-A2
1 of 13
Adgf-A
1 of 13
Adgf-B
1 of 13
Adgf-C
1 of 13
Adgf-D
1 of 13
Adgf-E
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    AMPD2; adenosine monophosphate deaminase 2
    13 of 14
    102771
     
    AMPD3; adenosine monophosphate deaminase 3
    9 of 14
    102772
      AMPD1; adenosine monophosphate deaminase 1
      8 of 14
      102770
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        AMPdeam - egg
        two hybrid, pull down, autoradiography
        (Stabell et al., 2006)
        Summary of Genetic Interactions
        Interaction Browsers
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
        External Data
        Linkouts
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        X
        Recombination map
        1-46
        Cytogenetic map
        12C6-12C7
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        12C6-12C7
        Limits computationally determined from genome sequence between P{EP}CG33174EP1101 and P{EP}EP1595EP1595
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        1-46

        (FlyBase, 2016)

        1-44.2

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (17)
        Genomic Clones (17)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (69)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments
            Relationship to Other Genes
            Source for database merge of

            Source for merge of: CG11058 CG15762 CG11065

            (Robertson, 2001.7.7)
            Additional comments

            Annotations CG11058, CG11065, CG15762 merged as CG32626 in release 3 of the genome annotation.

            (FlyBase Genome Annotators, 2002-2003)
            Nomenclature History
            Source for database identify of

            Source for identity of: AMPdeam CG32626

            (Stenesen et al., 2013)
            Nomenclature comments
            Etymology
            Synonyms and Secondary IDs (7)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 80 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
            References (60)