FlyBase Gene Report: Dmel\RpL41

General Information

Symbol

Dmel\RpL41

Species

D. melanogaster

Name

Ribosomal protein L41

Annotation Symbol

CG30425

Feature Type

protein_coding_gene

FlyBase ID

FBgn0066084

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

pncr005:2R , BcDNA:RE63504

Key Links

Genomic Location

Cytogenetic map

60E5-60E5

Sequence location

2R:24,903,416..24,903,935 [-]

Recombination map

2-107

RefSeq locus

NT_033778 REGION:24903416..24903935

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables structural constituent of ribosome

non-traceable author statement

(Kulkarni et al., 2002)

inferred from sequence or structural similarity with SGD:S000002343

(Gene Ontology Curators, 2002-)

traceable author statement

(Marygold et al., 2007)

inferred from electronic annotation with InterPro:IPR007836

(InterPro Project Members, 2004-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in cytoplasmic translation

traceable author statement

(Marygold et al., 2007)

inferred from sequence or structural similarity with SGD:S000002343

(Gene Ontology Curators, 2002-)

involved_in translation

non-traceable author statement

(Kulkarni et al., 2002)

inferred from electronic annotation with InterPro:IPR007836

(InterPro Project Members, 2004-)

Cellular Component (8 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Rugjee et al., 2013)

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

colocalizes_with nuclear chromosome

inferred from direct assay

(Rugjee et al., 2013)

located_in nucleolus

inferred from direct assay

(Rugjee et al., 2013)

located_in nucleoplasm

inferred from high throughput direct assay

(Lye et al., 2014)

located_in nucleus

inferred from direct assay

(Rugjee et al., 2013)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of cytosolic large ribosomal subunit

traceable author statement

(Marygold et al., 2007)

inferred from sequence or structural similarity with SGD:S000002343

(Gene Ontology Curators, 2002-)

non-traceable author statement

(Kulkarni et al., 2002)

located_in ribosome

inferred from electronic annotation with InterPro:IPR007836

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

CYTOPLASMIC LARGE RIBOSOMAL SUBUNIT

CYTOPLASMIC LARGE RIBOSOMAL SUBUNIT - TESTIS-SPECIFIC VARIANT

Protein Family (UniProt)

Protein Signatures (InterPro)

Large ribosomal subunit protein eS32

Summaries

Gene Group (FlyBase)

CYTOPLASMIC LARGE RIBOSOMAL SUBUNIT -: Cytoplasmic ribosomes are found on the endoplasmic reticulum and in the cytosol. They translate all mRNAs produced from nuclear genes and perform the majority of cellular protein synthesis. Ribosomes are formed by two ribonucleoprotein subunits, large and small. The principle function of the large subunit is to bind tRNA during the synthesis of polypeptides. (Adapted from FBrf0205398.)
CYTOPLASMIC LARGE RIBOSOMAL SUBUNIT - TESTIS-SPECIFIC VARIANT -: Cytoplasmic ribosomes are found on the endoplasmic reticulum and in the cytosol. They translate all mRNAs produced from nuclear genes and perform the majority of cellular protein synthesis. Ribosomes are formed by two ribonucleoprotein subunits, large and small. The principle function of the large subunit is to bind tRNA during the synthesis of polypeptides. Tissue expression data from modENCODE has been used to infer the composition of the cytosolic large ribosomal subunit testis-specific variant. (Adapted from FBrf0205398.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\RpL41 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q962S2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

Comments on Gene Model

Gene model reviewed during 5.39

Gene model reviewed during 5.44

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

RpL41-RA

FBtr0100231

NM_001014551

320

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

RpL41-PA

FBpp0099610

3.4

13.46

Q962S2

NP_001014551

AAX52686

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Large ribosomal subunit protein eS32

PDB - An information portal to biological macromolecular structures

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q962S2

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RpL41 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

RpL41_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.22

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Rugjee et al., 2013)

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

colocalizes_with nuclear chromosome

inferred from direct assay

(Rugjee et al., 2013)

located_in nucleolus

inferred from direct assay

(Rugjee et al., 2013)

located_in nucleoplasm

inferred from high throughput direct assay

(Lye et al., 2014)

located_in nucleus

inferred from direct assay

(Rugjee et al., 2013)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\RpL41 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\RpL41

View exonic expression by tissue for Dmel\RpL41

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

251466/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0066084

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0066084

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0066084

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG30425

Flygut - An atlas of the Drosophila adult midgut

FBgn0066084

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of RpL41

Transgenic constructs containing regulatory region of RpL41

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(2R)ED4071

(Marygold et al., 2007)

Df(2R)ED9069

(Marygold et al., 2007)

Df(2R)M60E

(Marygold et al., 2007)

Inferred from location ( 9 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Scer\GAL4^Mef2.PR

RpL41^GD14507

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP007087

3 of 12

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:RpL41. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

RpL41 - Rack1

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL10

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL10Ab

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL11

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL12

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL13

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL13A

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL14

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL15

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL17

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL18

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL18A

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL19

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL21

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL22

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL23

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL23A

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL24

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL26

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL27

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL27A

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL28

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL29

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL3

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL30

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL31

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL32

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL34a

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL35

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL35A

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL36

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL36A

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL37-1

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL37A

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL38

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL39

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL4

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL40

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL5

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL6

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL7

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL7A

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL8

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpL9

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpLP0

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpLP1

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpLP2

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS10a

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS11

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS12

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS13

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS14a

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS14b

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS15

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS15Aa

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS16

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS17

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS18

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS19a

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS2

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS20

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS21

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS23

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS24

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS25

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS26

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS27

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS27A

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS28b

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS29

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS3

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS30

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS3A

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS4

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS5a

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS6

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS7

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS8

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - RpS9

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - eEF2

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - sta

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - vig2

cosedimentation, electron microscopy

(Anger et al., 2013)

RNA-protein

Physical Interaction

Assay

References

RpL41 - 18SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - 28SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - 2SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - 5.8SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL41 - 5SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

75542

DroID - A comprehensive database of gene and protein interactions.

FBgn0066084

MIST (protein-protein) - An integrated Molecular Interaction Database

251466

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Ribosome

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-107

Cytogenetic map

60E5-60E5

Sequence location

2R:24,903,416..24,903,935 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

60E5-60E5

Limits computationally determined from genome sequence between P{EP}CG9047^EP560&P{EP}CG3760^EP936 and P{EP}CG2790^EP412&P{EP}CG3776^EP835

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-107

(FlyBase, 2016)

2-111.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

17133

w¹¹¹⁸; P{EP}NaCP60E^EP348 RpL41^EP348/CyO

15457

y¹ w^67c23; P{EPgy2}NaCP60E^EY05570 RpL41^EY05570

33231

w^*; P{ID.QF}NaCP60E^Q10B RpL41^Q10B; Pri¹/TM6B, Tb¹

FlyORF

F001596

M{UAS-RpL41.ORF}ZH-86Fb

F001018

M{UAS-RpL41.ORF.3xHA}ZH-86Fb

Kyoto

115344

w¹¹¹⁸; PBac{754.P.FSVS-0}RpL41^CPTI002881

114455

y^d2 w¹¹¹⁸ P{ey-FLP.N}2; P{neoFRT}42D P{EP}NaCP60E^EP348 /CyO y⁺

NIG-Fly

HMJ21806

y¹ v¹; P{TRiP.HMJ21806}attP40/CyO

VDRC

v103332

P{KK112906}VIE-260B

v45823

w¹¹¹⁸; P{GD14507}v45823/TM3

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (391)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0066084

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0066084

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Not a Minute gene.

(Marygold et al., 2007)

Deletions removing RpL41 but no other cytoplasmic ribosomal protein-encoding genes do not show Minute phenotypes.

(Marygold et al., 2007)

Molecularly-defined mutations in RpL41 do not result in Minute phenotypes.

(Marygold et al., 2007)

Annotation CR30425 renamed CG30425 in release 4.1 of the genome annotation.

(FlyBase Genome Annotators, 2005)

New annotation (CR30425) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

RpL41 is nested in the second intron of NaCP60E, in the opposite orientation. The P{lArB}NaCP60E^smi60E insertion (which results in a smell-impaired phenotype) maps within an intron of NaCP60E and is also near the promoter region of RpL41 (which is nested within the second intron of NaCP60E). Evidence indicates that the smell-impaired phenotype caused by the P{lArB}NaCP60E^smi60E insertion is due to an effect on NaCP60E and not RpL41; a revertant of NaCP60E^smi60E showing wild-type olfactory behaviour (NaCP60E^smi60E-rev16) shows full restoration of NaCP60E transcript expression and a massive reduction in RpL41 transcription. Overall orientation not stated: NaCP60E+ RpL41- NaCP60E+

(Kulkarni et al., 2002)

Identified with: LP07070.5prime <up>FlyBase curator comment: EST subsequently found to be chimeric</up>.

(Oliver, 2001.8.16)

Identified with: LP07070 (BDGP-DGC) <up>FlyBase curator comment: EST subsequently found to be chimeric</up>.

(BDGP Project Members, 2000-)

EST LP07070 is chimeric; the 5' portion matches part of AE003542 on the opposite strand to Adk1, the 3' portion corresponds to part of RpL41.

(FlyBase, 1996-)

Relationship to Other Genes

Source for database merge of

Source for merge of: RpL41 CR30425

(FlyBase, 1996-)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: BcDNA:RE63504 CR30425

(FlyBase Genome Annotators, 2002-2003)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

BEST:LP07070

BcDNA:LP07070

BcDNA:RE63504

(Giot et al., 2003)

CG30425

(National Institute of Genetics Fly Stocks, 2023-, Schertel et al., 2013, Keleman et al., 2009.8.5, Marygold et al., 2007, FlyBase Genome Annotators, 2005, Tupy, 2005.4.22)

CR30425

L41

(Kulkarni et al., 2002)

L41e

(Anger et al., 2013)

RpL41

(Adashev et al., 2022, Loganathan et al., 2022, Jin et al., 2020, DeSalvo et al., 2014, Handler et al., 2013, Rugjee et al., 2013, Schertel et al., 2013, Fischer et al., 2012, Winbush et al., 2012, Abruzzi et al., 2011, Marygold et al., 2007, Reiter et al., 2007)

Rpl41

(Baker et al., 2021, Lefebvre et al., 2016)

pncr005:2R

(Rugjee et al., 2013, Tupy et al., 2005, Tupy et al., 2005)

Name Synonyms

Ribosomal protein L41

(Kulkarni et al., 2002)

putative noncoding RNA 005:2R

(Tupy et al., 2005)

Secondary FlyBase IDs

FBgn0046237
FBgn0047072
FBgn0050425
FBgn0063106

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 34 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

251466

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q962S2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q962S2

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q962S2

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

251466/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0066084

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0066084

FlyMine - An integrated database for Drosophila genomics

FBgn0066084

InterPro - A database of protein families, domains and functional sites

Large ribosomal subunit protein eS32

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG30425

MARRVEL_MODEL - MARRVEL (model organism gene)

251466

PDB - An information portal to biological macromolecular structures

Linkouts

BioGRID - A database of protein and genetic interactions.

75542

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0066084

DroID - A comprehensive database of gene and protein interactions.

FBgn0066084

DRSC - Results frm RNAi screens

FBgn0066084

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

RpL41_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0066084

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0066084

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG30425

Flygut - An atlas of the Drosophila adult midgut

FBgn0066084

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC034504

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Ribosome

MIST (protein-protein) - An integrated Molecular Interaction Database

251466

References (47)

The following external sites may use different assemblies or annotations than FlyBase.

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