FlyBase Gene Report: Dmel\Epac

General Information

Symbol

Dmel\Epac

Species

D. melanogaster

Name

Exchange protein directly activated by cAMP

Annotation Symbol

CG34392

Feature Type

protein_coding_gene

FlyBase ID

FBgn0085421

Gene Model Status

Current

Stock Availability

15 publicly available

Gene Summary

Exchange protein directly activated by cAMP (Epac) encodes a guanine nucleotide exchange factor for the Ras-like small GTPases encoded by Rap1 and Rap2l. It is involved in transducing cAMP effects during synaptic potentiation, neuronal differentiation and renal secretion. [Date last reviewed: 2019-02-28] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Dm_2R:10367

Key Links

Genomic Location

Cytogenetic map

42C8-42D1

Sequence location

2R:6,759,715..6,798,941 [-]

Recombination map

2-55

RefSeq locus

NT_033778 REGION:6759715..6798941

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables guanyl-nucleotide exchange factor activity

inferred from electronic annotation with InterPro:IPR001895, InterPro:IPR008937, InterPro:IPR019804, InterPro:IPR036964

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000560991

(GO Reference Genome Project, 2011-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in regulation of Rap protein signal transduction

inferred from genetic interaction with FLYBASE:Rap1; FB:FBgn0004636

(Dupuy et al., 2005)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in intracellular signal transduction

inferred from electronic annotation with InterPro:IPR000591

(InterPro Project Members, 2004-)

involved_in Ras protein signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN000560991

(GO Reference Genome Project, 2011-)

involved_in signal transduction

inferred from electronic annotation with InterPro:IPR000159

(InterPro Project Members, 2004-)

involved_in small GTPase-mediated signal transduction

inferred from electronic annotation with InterPro:IPR001895, InterPro:IPR008937, InterPro:IPR019804, InterPro:IPR036964

(InterPro Project Members, 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN007734601

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS -: RasGEFs are Guanine Nucleotide Exchange Factors (GEFs) for Ras family GTPases. The RasGEFs are characterized by a CDC25 homology domain. (Adapted from FBrf0220530).

Summary (Interactive Fly)

guanine nucleotide exchange factor - noncanonical cAMP sensor involved aversive odor learning - required for activity of bacterial adenylate cyclase - stimulated fluid secretion in Malphigian tubules

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Epac for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A1Z6P8)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.48

Gene model reviewed during 5.43

Low-frequency RNA-Seq exon junction(s) not annotated.

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 6.32

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Epac-RD

FBtr0112636

NM_165490

4044

861

Epac-RE

FBtr0329849

NM_001103732

6597

1006

Epac-RF

FBtr0329850

NM_001273807

4043

935

Epac-RH

FBtr0479928

NM_001273808

3662

947

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Epac-PD

FBpp0111548

97.4

861

6.92

FBpp0302889

113.8

1006

6.85

FBpp0302890

105.9

935

7.02

FBpp0428260

106.7

947

7.79

AGB93270

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Epac using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.51

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9 -- 12

midline primordium | subset

(Kearney et al., 2004)

embryonic stage 13 -- 16

midline glial cell

(Kearney et al., 2004)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Epac in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Epac

View exonic expression by tissue for Dmel\Epac

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0085421

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35588/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0085421

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0085421

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0085421

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3427

Flygut - An atlas of the Drosophila adult midgut

FBgn0085421

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 13 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Epac

Transgenic constructs containing regulatory region of Epac

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2R)Exel6050

(Ryder, 2004.4.26)

Gene partially disrupted in

Df(2R)Epac^Δ2

(Schwarzel, 2018.9.21, Richlitzki et al., 2017)

Inferred from location ( 9 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Epac^f07038

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^tin.CΔ4

Epac^GD16734

viable (with Epac^Δ1)

Epac^Δ3

viable (with Epac^Δ3)

Epac^Δ1

Sterility

Allele

fertile

Epac^f07038

fertile (with Epac^Δ1)

Epac^Δ3

fertile (with Epac^Δ3)

Epac^Δ1

Other Phenotypes

Allele

abnormal neurophysiology | larval stage (with Epac^Δ1)

Epac^Δ3

abnormal neurophysiology | larval stage (with Epac^Δ3)

Epac^Δ1

Phenotype manifest in

Allele

embryonic/larval neuromuscular junction | larval stage (with Epac^Δ1)

Epac^Δ3

embryonic/larval neuromuscular junction | larval stage (with Epac^Δ3)

Epac^Δ1

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (25)

Hsap\RAPGEF4

13 of 14

Yes

Hsap\RAPGEF3

10 of 14

Yes

Hsap\RAPGEF5

8 of 14

Yes

Hsap\RAPGEFL1

5 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (25)

Rnor\Rapgef3

11 of 14

Yes

Rnor\Rapgef4

8 of 14

Yes

Rnor\Rapgef5

7 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Rasgrf2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (38)

Mmus\Rapgef4

13 of 14

Yes

Mmus\Rapgef3

10 of 14

Yes

Mmus\Rapgef5

8 of 14

Yes

Mmus\Rapgefl1

5 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Sos1

1 of 14

Mmus\Sos2

1 of 14

Xenopus tropicalis (Western clawed frog) (16)

Xtro\rapgef4

11 of 13

Yes

Xtro\rapgef3

5 of 13

Yes

Xtro\rapgef5

4 of 13

Yes

Xtro\rapgefl1

3 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\rasgrp1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (29)

Drer\rapgef4a

12 of 14

Yes

Drer\rapgef4b

11 of 14

Yes

Drer\rapgef3

10 of 14

Yes

Drer\rapgef5a

6 of 14

Yes

Drer\rapgef5b

6 of 14

Yes

Drer\rapgefl1

5 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

Drer\LOC101885382

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\rasgrp3

1 of 14

Yes

Drer\rasgrp4

1 of 14

Yes

Drer\rgl2

1 of 14

Drer\sos1

1 of 14

Drer\sos2

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (8)

Cele\epac-1

14 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\rgl-1

1 of 14

Cele\sos-1

1 of 14

Cele\Y34B4A.4

1 of 14

Anopheles gambiae (African malaria mosquito) (9)

Agam\AgaP_AGAP007307

12 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP004853

1 of 12

Agam\AgaP_AGAP008775

1 of 12

Agam\AgaP_AGAP009180

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\BUD5

1 of 13

Yes

Scer\CDC25

1 of 13

Yes

Scer\IML1

1 of 13

Yes

Scer\LTE1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\efc25

1 of 12

Yes

Spom\ste6

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Epac. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (8)

PDZ-GEF

4 of 13

Rgl

4 of 13

C3G

3 of 13

CG4853

3 of 13

CG7369

3 of 13

RalGPS

3 of 13

Sos

3 of 13

CG34393

2 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RAPGEF4; Rap guanine nucleotide exchange factor 4

13 of 14

606058

RAPGEF3; Rap guanine nucleotide exchange factor 3

10 of 14

606057

RAPGEF5; Rap guanine nucleotide exchange factor 5

8 of 14

609527

RAPGEFL1; Rap guanine nucleotide exchange factor like 1

5 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Rap1

suppressible

Epac

(Dupuy et al., 2005)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

61484

DroID - A comprehensive database of gene and protein interactions.

FBgn0085421

MIST (protein-protein) - An integrated Molecular Interaction Database

35588

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-55

Cytogenetic map

42C8-42D1

Sequence location

2R:6,759,715..6,798,941 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

42C8-42D1

Limits computationally determined from genome sequence between P{lacW}geminin^k14019&P{PZ}Adf1⁰¹³⁴⁹ and P{lacW}ubl^k03203&P{PZ}CG3287⁰⁹⁹⁶⁷

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-55

(FlyBase, 2016)

2-56.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (15)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

19033

w¹¹¹⁸; PBac{WH}Epac^f07038

29317

y¹ v¹; P{TRiP.JF02476}attP2

42380

y¹ w^*; Mi{MIC}Epac^MI06245

56410

y¹ w^*; Mi{MIC}Epac^MI11261

13663

y¹ w^67c23; P{SUPor-P}Epac^KG00434

66364

y¹ w^*; Mi{PT-GFSTF.0}Epac^{MI06245-GFSTF.0}

80670

y¹ w^*; TI{CRIMIC.TG4.1}Epac^{CR00799-TG4.1}/SM6a

52093

y¹ w^*; Mi{MIC}Cyp6a2^MI09313 Epac^MI09313/SM6a

78799

w^*; Df(2R)Epac^Δ1, Epac^Δ1/Df(2R)Epac^Δ3, Epac^Δ3

NIG-Fly

2RG-0519

y² VhaAC39-1^cho-1 v¹; P{U6-Epac.NIG.sgRNA}attP40/CyO

VDRC

v110077

P{KK108597}VIE-260B

v50372

w¹¹¹⁸; P{GD16734}v50372

More stocks available...

Genomic Clones (40)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (73)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH01501

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0085421

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0085421

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: Epac CG15235

(FlyBase Genome Annotators, 2007)

Additional comments

Annotations CG3427 and CG15235 merged as CG34392 in release 5.2 of the genome annotation.

(FlyBase Genome Annotators, 2007)

Nomenclature History

Source for database identify of

Source for identity of: Epac CG3427

(Sebastien and Camonis, 2003)

Nomenclature comments

Etymology

Named "Epac" after the human ortholog.

(FlyBase, 2009-)

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

CG15235

CG3427

(Praveen et al., 2012, Lin et al., 2010, van Dam et al., 2009, Schneider et al., 2004, Giot et al., 2003, Brody et al., 2002)

CG34392

(National Institute of Genetics Fly Stocks, 2022-, Meadows, 2014.12.12, Garcia et al., 2013, Pessa et al., 2010, Willis et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, FlyBase Genome Annotators, 2007)

D-EPAC

(Sebastien and Camonis, 2003)

D-Epac

(Dupuy et al., 2005)

Dm_2R:10367

(FlyBase Genome Annotators, 2014, Ladoukakis et al., 2011)

Epac1

(Metaxakis et al., 2023)

epac

(Richlitzki et al., 2017, Gupta et al., 2014, Efetova et al., 2013, Shakiryanova et al., 2011, Sandmann et al., 2007)

Name Synonyms

Epac Guanine Nucleotide Exchange Factor

(Willis et al., 2010)

Exchange protein directly activated by cAMP

Exchange protein directly activated by cAMP ortholog

Secondary FlyBase IDs

FBgn0033102
FBgn0033103

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 68 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35588

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A1Z6P8

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A1Z6P8

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0085421

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35588/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0085421

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0085421

FlyMine - An integrated database for Drosophila genomics

FBgn0085421

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG34392

MARRVEL_MODEL - MARRVEL (model organism gene)

35588

Linkouts

BioGRID - A database of protein and genetic interactions.

61484

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0085421

DroID - A comprehensive database of gene and protein interactions.

FBgn0085421

DRSC - Results frm RNAi screens

FBgn0085421

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0085421

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0085421

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3427

Flygut - An atlas of the Drosophila adult midgut

FBgn0085421

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0085421

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

35588

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

References (91)

The following external sites may use different assemblies or annotations than FlyBase.

-0.51

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