Amyotrophic lateral sclerosis is a neurodegenerative disorder characterized by the death of motor neurons in the brain, brainstem, and spinal cord, resulting in fatal paralysis. ALS usually begins with asymmetric involvement of the muscles in middle adult life. Approximately 10% of ALS cases are familial (Siddique and Deng, 1996, pubmed:8875253). ALS is sometimes referred to as 'Lou Gehrig disease' after the famous American baseball player who was diagnosed with the disorder. [from MIM:105400, 2015.02.11]

See general description of amyotrophic lateral sclerosis, above.

ALS11 is an autosomal dominant form of ALS caused by mutation in the FIG4 gene [from MIM:612577; 2016.06.22]

FIG4 Phosphoinositide 5-Phosphatase (FIG4) encodes a protein in the SAC domain-containing protein family; the SAC domain incorporates the phosphoinositide phosphatase activity. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. [from Gene Cards, FIG4; 2016.06.22]

One to one: 1 human to 1 Drosophila.

Ortholog of human FIG4 (1 Drosophila to 1 human). Dmel\FIG4 shares 41% identity and 58% similarity with the human gene.