FB2026_03 , released September 17, 2026
Human Disease Model Report: alcohol, response to, dual-GPCR signaling
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General Information
Name
alcohol, response to, dual-GPCR signaling
FlyBase ID
FBhh0000904
Disease Ontology Term
Parent Disease
OMIM
Overview

The Drosophila gene DopEcR is a dual G-protein-coupled receptor (GPCR) that can be activated by dopamine and by the insect steroid hormone ecdysone; it is postulated to link GPCR-mediated non-genomic steroid action to cAMP signaling in the fly nervous system. DopEcR has been shown to modulate a number of complex behaviors in flies, including response to ethanol.

RNAi targeting constructs and alleles caused by insertional mutagenesis have been generated for Dmel\DopEcR. Genetic interactions have been described; see the DopEcR gene report.

[updated Oct. 2018 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: alcohol, response to, dual-GPCR signaling
OMIM report
Human gene(s) implicated
Symptoms and phenotype

Steroid hormones possess two distinct actions, a delayed genomic effect and a rapid non-genomic effect. Rapid steroid-triggered signaling is mediated by specific receptors localized most often to the plasma membrane; among these are G protein-coupled receptors (GPCRs) (Wang et al., 2014; pubmed:25257522).

(FlyBase Curators, 2013-)
Genetics
Cellular phenotype and pathology
Molecular information

Dmel\DopEcR is postulated to link GPCR-mediated non-canonical steroid action to cAMP signaling in the fly nervous system (FBrf0223024).

(FlyBase Curators, 2013-)
External links
    Disease synonyms
    alcohol, response to, dual-GPCR-signaling
    alcohol, response to, steroid hormone-related
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (1)
        Dmel\DopEcR
        Gene Snapshot
        Dopamine/Ecdysteroid receptor (DopEcR) encodes a GPCR that shows ligand-biased activation. It can be activated by dopamine to increase cyclic AMP levels and by the insect steroid ecdysone to activate the MAPKinase pathway. It is widely expressed in the nervous system and can modulate a wide variety of complex behaviors including male courtship, locomotion, the response to stressful social interactions and the regulation of appetite. [Date last reviewed: 2019-03-07]
        Molecular function (GO)
        Cellular component (GO)
        Gene Groups / Pathways
        Comments on ortholog(s)

        A number of human genes encoding GPCR's show low levels of homology to Dmel\DopEcR, including GPR52 and GPR21 (24-26% identity and 42-46% similarity).

        Orthologs and Alignments from DRSC
        DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans
        H. sapiens (Human)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (4 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila transgenes
          Allele
          Transgene
          Publicly Available Stocks
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          DopEcRRNAi.UAS.cXa
          P{UAS-DopEcR.RNAi.X}
          w*; P{UAS-DopEcR.RNAi.X}3/TM6C, Sb1
          DopEcRGD641
          P{GD641}
          DopEcRKK111211
          P{KK111211}
          P{KK111211}VIE-260B
          DopEcRJF03415
          P{TRiP.JF03415}
          y1 v1; P{TRiP.JF03415}attP2
          DopEcRRNAi.UAS.cEa
          P{UAS-DopEcR.RNAi.E}
          DopEcRVSH330061
          P{VSH330061}
          P{VSH330061}attP40
          Selected Drosophila classical alleles
          Allele
          Allele class
          Mutagen
          Publicly Available Stocks
          DopEcRc02142
          piggyBac activity
          w1118; PBac{PB}DopEcRc02142/TM6B, Tb1
          DopEcRMI02790
          DopEcRGAL4
          gene targeting by homologous recombination
          References (5)