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Citation
Zhang, N., Zhang, J., Cheng, Y., Howard, K. (1996). Identification and genetic analysis of wunen, a gene guiding Drosophila melanogaster germ cell migration.  Genetics 143(3): 1231--1241.
FlyBase ID
FBrf0089219
Publication Type
Research paper
Abstract

We describe a novel genetic locus, wunen (wun), required for guidance of germ cell migration in early Drosophila development. Loss of wun function does not abolish movement but disrupts the orientation of the motion causing the germ cells to disperse even though their normal target, the somatic gonad, is well formed. We demonstrate that the product of this gene enables a signal to pass from the soma to the germ line and propose that the function of this signal is to selectively stabilize certain cytoplasmic extensions resulting in oriented movement. To characterize this guidance factor, we have mapped wun to within 100 kb of cloned DNA.

PubMed ID
PubMed Central ID
PMC1207393 (PMC) (EuropePMC)
DOI
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genetics
    Title
    Genetics
    Publication Year
    1916-
    ISBN/ISSN
    0016-6731
    Data From Reference