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Citation
Rong, Y.S., Golic, K.G. (2000). Gene targeting by homologous recombination in Drosophila.  Science 288(5473): 2013--2018.
FlyBase ID
FBrf0128625
Publication Type
Research paper
Abstract

Drosophila offers many advantages as an experimental organism. However, in comparison with yeast and mouse, two other widely used eukaryotic model systems, Drosophila suffers from an inability to perform homologous recombination between introduced DNA and the corresponding chromosomal loci. The ability to specifically modify the genomes of yeast and mouse provides a quick and easy way to generate or rescue mutations in genes for which a DNA clone or sequence is available. A method is described that enables analogous manipulations of the Drosophila genome. This technique may also be applicable to other organisms for which gene-targeting procedures do not yet exist.

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Note

Reversal of fortune for Drosophila geneticists?
Engels, 2000, Science 288(5473): 1973--1975 [FBrf0128456]

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075 1095-9203
    Data From Reference