Guss, K.A., Nelson, C.E., Hudson, A., Kraus, M.E., Carroll, S.B. (2001). Control of a genetic regulatory network by a selector gene. Science 292(5519): 1164--1167.
FlyBase ID
FBrf0135948
Publication Type
Research paper
Abstract
The formation of many complex structures is controlled by a special class of transcription factors encoded by selector genes. It is shown that SCALLOPED, the DNA binding component of the selector protein complex for the Drosophila wing field, binds to and directly regulates the cis-regulatory elements of many individual target genes within the genetic regulatory network controlling wing development. Furthermore, combinations of binding sites for SCALLOPED and transcriptional effectors of signaling pathways are necessary and sufficient to specify wing-specific responses to different signaling pathways. The obligate integration of selector and signaling protein inputs on cis-regulatory DNA may be a general mechanism by which selector proteins control extensive genetic regulatory networks during development.
