Pfleger, C.M., Wang, J., Friedman, L., Vittorino, R., Conley, L.M., Ho, L., Fivecoat, H.C., Pasinetti, G.M. (2010). Grape-seed polyphenolic extract improves the eye phenotype in a Drosophila model of tauopathy. Int. J. Alzheimers Dis. 2010(): .
FlyBase ID
FBrf0211898
Publication Type
Research paper
Abstract
Drosophila models of tauopathies have been developed by transgenically overexpressing the disease-associated forms of tau. In this paper we report for the first time that a recently developed Grape-Seed Polyphenolic Extract (GSPE) improves the eye phenotype of a Drosophila eye model of R406W tau. GSPE-mediated improvements in this distinct in vivo neurodegeneration model for protein misfolding/aggregation suggest that GSPE may have therapeutic value in disorders involving aberrant protein aggregation.
