Open Close
Reference
Citation
Kim, K., Lin, Y.R., Park, Y. (2010). Enhancement of stress resistances and downregulation of Imd pathway by lower developmental temperature in Drosophila melanogaster.  Exp. Gerontol. 45(12): 984--987.
FlyBase ID
FBrf0212401
Publication Type
Research paper
Abstract

Ambient temperature affects the lifespan of cold-blooded organisms such as Drosophila melanogaster. To better understand what influences the lifespan of an adult fruit fly, we tested whether developmental temperature could affect stress responses used as surrogate markers for the aging process. When 2-day-old adult flies developed at two representative temperatures (18°C and 25°C) were challenged with three stresses (starvation, oxidation, and heat), both male and female flies developed at 18°C exhibited stronger resistance to all three stresses compared to those developed at 25°C. Nutrient composition analyses showed that fat, protein, and glycogen levels increased when male flies were developed at 18°C. These differences in stress resistance by developmental temperature were sustained even between 30-day-old male flies of two groups aged at the same temperature. We also showed that development at a lower temperature represented by 18°C significantly downregulates anti-microbial peptide genes, AttA and DptB, of Imd pathway.

PubMed ID
PubMed Central ID
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Exp. Gerontol.
    Title
    Experimental Gerontology
    Publication Year
    1964-
    ISBN/ISSN
    0531-5565
    Data From Reference
    Genes (18)