Open Close
Reference
Citation
Ismail, J.N., Badini, S., Frey, F., Abou-Kheir, W., Shirinian, M. (2019). Drosophila Tet Is Expressed in Midline Glia and Is Required for Proper Axonal Development.  Front. Cell. Neurosci. 13(): 252.
FlyBase ID
FBrf0242694
Publication Type
Research paper
Abstract

Ten-Eleven Translocation (TET) proteins are important epigenetic regulators that play a key role in development and are frequently deregulated in cancer. Drosophila melanogaster has a single homologous Tet gene (dTet) that is highly expressed in the central nervous system during development. Here, we examined the expression pattern of dTet in the third instar larval CNS and discovered its presence in a specific set of glia cells: midline glia (MG). Moreover, dTet knockdown resulted in significant lethality, locomotor dysfunction, and alterations in axon patterning in the larval ventral nerve cord. Molecular analyses on dTet knockdown larvae showed a downregulation in genes involved in axon guidance and reduced expression of the axon guidance cue Slit. Our findings point toward a potential role for dTet in midline glial function, specifically the regulation of axon patterning during neurodevelopment.

PubMed ID
PubMed Central ID
PMC6558204 (PMC) (EuropePMC)
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Front. Cell. Neurosci.
    Title
    Frontiers in cellular neuroscience
    ISBN/ISSN
    1662-5102
    Data From Reference
    Alleles (6)
    Genes (8)
    Insertions (1)
    Transgenic Constructs (5)