DsRed-Express2 is a tetrameric red fluorescent protein with an excitation peak of 554nm and an emission peak of 591nm in vitro. It is an artificial derivative of the naturally occurring fluorescent protein encoded by the Discosoma drFP583 gene (GenBank:AF168419; AAF03369), containing the mutations A2D, S4T, D6N, E10P, R17H, R36K, K47Q, S117T, K121H, M141L, A145P, D169G, Q188K, I210V, G219A and L225Q relative to DsRed(T1). DsRed-Express2 has minimal cytotoxicity (PMID:18953349).