DsRed(E5) is a tetrameric fluorescent timer protein that changes its fluorescence from over time, from an initial bright green fluorescence to yellow, orange and finally red. It is an artificial derivative of the naturally occurring fluorescent protein encoded by the Discosoma drFP583 gene (GenBank:AF168419; AAF03369), derived by mutagenesis of DsRed1. It contains the mutations V105A and S197T relative to DsRed1 (PMID:11090358).