Allele Dmel\mts⁰²⁴⁹⁶

General Information
Symbol	Dmel\mts⁰²⁴⁹⁶	Species	D. melanogaster
Name		FlyBase ID	FBal0008000
Feature type	allele	Associated gene	Dmel\mts

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	P-element activity
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 2L:7,827,731..7,827,732 2L:7,827,796..7,827,796 (Wassarman et al., 1996, BDGP Project Members, 1994-1999, Spradling et al., 1999, Casso et al., 2008, Chen et al., 2008, Ogawa et al., 2009)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference P{PZ} is inserted 320bp upstream of the translation start site of mts. (Wassarman et al., 1996)
Caused by insertion	P{PZ}mts⁰²⁴⁹⁶ (Wassarman et al., 1996, BDGP Project Members, 1994-1999, Spradling et al., 1999, Casso et al., 2008, Chen et al., 2008, Ogawa et al., 2009)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| recessive (Wassarman et al., 1996) lethal \| recessive (Spradling et al., 1999)
Phenotype Manifest In

Detailed Description
	Statement Reference mts[02496]/mts[XE-2258] mutant embryos do not exhibit any defects in neuroblast division at stage 10 of embryogenesis. mts[02496]/mts[XE-2258] mitotic neuroblasts display normal mira localisation. (Ogawa et al., 2009)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference mts⁰²⁴⁹⁶ is an enhancer of cell polarity defective phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, aPKC^{CAAXWT.Scer\UAS} (Ogawa et al., 2009)
NOT Enhancer of
Statement Reference mts⁰²⁴⁹⁶ is a non-enhancer of visible phenotype of Scer\GAL4^ptc-559.1, smo^{dsRNA.Scer\UAS.WIZ} (Casso et al., 2008)
Suppressor of
Statement Reference mts[+]/mts⁰²⁴⁹⁶ is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, foxo^GS9928, wdb^GS9548 (Vereshchagina et al., 2008)
NOT Suppressor of
Statement Reference mts[+]/mts⁰²⁴⁹⁶ is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, foxo^GS9928 (Vereshchagina et al., 2008)
Other
Statement Reference l(2)gl^ts3/l(2)gl⁴, mts⁰²⁴⁹⁶ has eclosion rhythm defective phenotype (Ogawa et al., 2009)
Phenotype Manifest In
Enhancer of
Statement Reference mts⁰²⁴⁹⁶ is an enhancer of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, aPKC^{CAAXWT.Scer\UAS} (Ogawa et al., 2009) mts⁰²⁴⁹⁶ is an enhancer of mechanosensory chaeta \| heat sensitive phenotype of l(2)gl^ts3/l(2)gl⁴ (Ogawa et al., 2009)
NOT Enhancer of
Statement Reference mts⁰²⁴⁹⁶ is a non-enhancer of wing vein phenotype of Scer\GAL4^ptc-559.1, smo^{dsRNA.Scer\UAS.WIZ} (Casso et al., 2008)
Suppressor of
Statement Reference mts[+]/mts⁰²⁴⁹⁶ is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, foxo^GS9928, wdb^GS9548 (Vereshchagina et al., 2008)
NOT Suppressor of
Statement Reference mts[+]/mts⁰²⁴⁹⁶ is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, foxo^GS9928 (Vereshchagina et al., 2008)
Additional Comments
Genetic Interactions
Statement Reference The addition of one copy of mts[02496] to l(2)gl[4]/l(2)gl[ts3] flies reduces the eclosion rate to 72% and 42% respectively. The presence of one copy of mts[02496] in l(2)gl[4]/l(2)gl[ts3] flies increases the frequency of defective bristle formation to 33% and 64% respectively (compared to 28% in l(2)gl[4]/l(2)gl[ts3] mutants). (Ogawa et al., 2009) mts[02496]/+ has little effect on the eye phenotype of animals expressing foxo[GS9928] under the control of Scer\GAL4[GMR.PF]. mts[02496]/+ suppresses the eye phenotype of animals expressing wdb[GS9548] and foxo[GS9928] under the control of Scer\GAL4[GMR.PF]. (Vereshchagina et al., 2008)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	mts⁰⁵⁵⁵⁹ (BDGP Project Members, 1994-1999) mts^k06009 (BDGP Project Members, 1994-1999) mts^k09822 (BDGP Project Members, 1994-1999) mts^k12502 (BDGP Project Members, 1994-1999) mts^k16501 (BDGP Project Members, 1994-1999) mts^s5286 (BDGP Project Members, 1994-1999)
Comments
Stocks ( 1 )
Bloomington	11193 P{PZ}mts⁰²⁴⁹⁶ cn¹/CyO; ry⁵⁰⁶
Notes on Origin
Discoverer	A. Spradling.

Comments
	Complements: l(2)37Ad^02660b. Complements: Cka⁰⁵⁸³⁶. Complements: Bsg⁰⁶²⁴³. Complements: l(2)k00607^k00607. Complements: l(2)k05404^k05404. Complements: l(2)k10210^k10210. Complements: l(2)k11101^k11101. Complements: l(2)rL220^rL220. Complements: Cka^s1883. Complements: cuc¹. Complements: Bsg^gel. (BDGP Project Members, 1994-1999)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	l(2)02496 (Spradling et al., 1999) l(2)02496⁰²⁴⁹⁶ mts⁰²⁴⁹⁶ (Wang et al., 2008, Ogawa et al., 2009, Vereshchagina et al., 2008) Pp2A-28D⁰²⁴⁹⁶ PP2A⁰²⁴⁹⁶ (Lu et al., 2003)
Name Synonym
Secondary FlyBase IDs

References ( 12 )
Research paper	Ogawa et al., 2009, J. Cell Sci. 122(18): 3242--3249 Protein phosphatase 2A negatively regulates aPKC signaling by modulating phosphorylation of Par-6 in Drosophila neuroblast asymmetric divisions. [FBrf0209035] Casso et al., 2008, Genetics 178(3): 1399--1413 A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts. [FBrf0205418] Chen et al., 2008, Genome Res. 18(1): 123--136 Identification of novel modulators of mitochondrial function by a genome-wide RNAi screen in Drosophila melanogaster. [FBrf0202125] Vereshchagina et al., 2008, J. Cell Sci. 121(20): 3383--3392 The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila. [FBrf0206002] Wang et al., 2008, J. Neurosci. 28(6): 1444--1451 Role of protein phosphatase 2A in regulating the visual signaling in Drosophila. [FBrf0202809] Lu et al., 2003, Neuron 40(6): 1185--1197 Regulation of the Ca2+/CaM-responsive pool of CaMKII by scaffold-dependent autophosphorylation. [FBrf0167958] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489] Wassarman et al., 1996, Genes Dev. 10(3): 272--278 Protein phosphatase 2A positively and negatively regulates Ras1-mediated photoreceptor development in Drosophila. [FBrf0086675]
Personal communication to FlyBase	Deal et al., 2003.9.17, Isolation and characterization of Df(2L)BSC41. Isolation and characterization of Df(2L)BSC41. [FBrf0161614] Beaton, 1999.12.12, Alleles of the lines in the P-element paper. Alleles of the lines in the P-element paper. [FBrf0125032] Meister and Braun, 1995.10, lacZ expression patterns for P{} insertions at Bloomington. lacZ expression patterns for P{} insertions at Bloomington. [FBrf0083714] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]

Allele Dmel\mts02496

Allele Dmel\mts⁰²⁴⁹⁶