FlyBase Allele Report: Dmel\mts[02496]

(Bánréti et al., 2012, Ogawa et al., 2009, Casso et al., 2008, Chen et al., 2008, Spradling et al., 1999, Wassarman et al., 1996, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999)

lethal - all die during embryonic stage | recessive

(Wassarman et al., 1996)

some die during embryonic stage | recessive

(Wassarman et al., 1996)

Phenotype Manifest In

Detailed Description

Statement

Reference

Starvation induced formation of lysosomes/autolysosomes is blocked in mutant larvae.

(Bánréti et al., 2012)

mts⁰²⁴⁹⁶/mts^XE-2258 mutant embryos do not exhibit any defects in neuroblast division at stage 10 of embryogenesis.

mts⁰²⁴⁹⁶/mts^XE-2258 mitotic neuroblasts display normal mira localisation.

(Ogawa et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

mts⁰²⁴⁹⁶ is an enhancer of abnormal cell polarity phenotype of Scer\GAL4^GMR.PF, aPKC^{UAS.Tag:CAAX(Unk)}

(Ogawa et al., 2009)

NOT Enhancer of

Statement

Reference

mts[+]/mts⁰²⁴⁹⁶ is a non-enhancer of abnormal neuroanatomy | larval stage | somatic clone - tissue specific phenotype of Mitf^KK113614, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

mts⁰²⁴⁹⁶ is a non-enhancer of visible phenotype of Scer\GAL4^ptc-559.1, smo^RNAi.UAS.WIZ

(Casso et al., 2008)

Suppressor of

Statement

Reference

mts[+]/mts⁰²⁴⁹⁶ is a suppressor | partially of abnormal neuroanatomy | larval stage | somatic clone - tissue specific phenotype of Mitf^UAS.Tag:MYC, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

mts[+]/mts⁰²⁴⁹⁶ is a suppressor | partially of visible | adult stage phenotype of Mitf^UAS.cZa, Scer\GAL4^dpp.blk1

(Zhang et al., 2024)

mts[+]/mts⁰²⁴⁹⁶ is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, foxo^GS9928, wdb^GS9548

(Vereshchagina et al., 2008)

NOT Suppressor of

Statement

Reference

mts[+]/mts⁰²⁴⁹⁶ is a non-suppressor of abnormal neuroanatomy | larval stage | somatic clone - tissue specific phenotype of Mitf^KK113614, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

mts[+]/mts⁰²⁴⁹⁶ is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF, foxo^GS9928

(Vereshchagina et al., 2008)

Other

Statement

Reference

l(2)gl^ts3/l(2)gl⁴, mts⁰²⁴⁹⁶ has abnormal eclosion rhythm phenotype

(Ogawa et al., 2009)

Phenotype Manifest In

Enhancer of

Statement

Reference

mts⁰²⁴⁹⁶ is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, aPKC^{UAS.Tag:CAAX(Unk)}

(Ogawa et al., 2009)

mts⁰²⁴⁹⁶ is an enhancer of mechanosensory chaeta | heat sensitive phenotype of l(2)gl^ts3/l(2)gl⁴

(Ogawa et al., 2009)

NOT Enhancer of

Statement

Reference

mts[+]/mts⁰²⁴⁹⁶ is a non-enhancer of developing neuron | larval stage | ectopic | somatic clone - tissue specific phenotype of Mitf^KK113614, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

mts[+]/mts⁰²⁴⁹⁶ is a non-enhancer of eye disc | larval stage | somatic clone - tissue specific phenotype of Mitf^KK113614, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

mts[+]/mts⁰²⁴⁹⁶ is a non-enhancer of peripodial epithelium of eye disc | larval stage | somatic clone - tissue specific phenotype of Mitf^KK113614, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

mts⁰²⁴⁹⁶ is a non-enhancer of wing vein phenotype of Scer\GAL4^ptc-559.1, smo^RNAi.UAS.WIZ

(Casso et al., 2008)

Suppressor of

Statement

Reference

mts[+]/mts⁰²⁴⁹⁶ is a suppressor | partially of wing phenotype of Mitf^UAS.cZa, Scer\GAL4^dpp.blk1

(Zhang et al., 2024)

mts[+]/mts⁰²⁴⁹⁶ is a suppressor | partially of eye disc | larval stage | somatic clone - tissue specific phenotype of Mitf^UAS.Tag:MYC, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

mts[+]/mts⁰²⁴⁹⁶ is a suppressor | partially of developing neuron | larval stage | decreased number | somatic clone - tissue specific phenotype of Mitf^UAS.Tag:MYC, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

mts[+]/mts⁰²⁴⁹⁶ is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, foxo^GS9928, wdb^GS9548

(Vereshchagina et al., 2008)

NOT Suppressor of

Statement

Reference

mts[+]/mts⁰²⁴⁹⁶ is a non-suppressor of developing neuron | ectopic | larval stage | somatic clone - tissue specific phenotype of Mitf^KK113614, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

mts[+]/mts⁰²⁴⁹⁶ is a non-suppressor of eye disc | larval stage | somatic clone - tissue specific phenotype of Mitf^KK113614, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

mts[+]/mts⁰²⁴⁹⁶ is a non-suppressor of peripodial epithelium of eye disc | larval stage | somatic clone - tissue specific phenotype of Mitf^KK113614, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

mts[+]/mts⁰²⁴⁹⁶ is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, foxo^GS9928

(Vereshchagina et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of one copy of mts⁰²⁴⁹⁶ to l(2)gl⁴/l(2)gl^ts3 flies reduces the eclosion rate to 72% and 42% respectively.

The presence of one copy of mts⁰²⁴⁹⁶ in l(2)gl⁴/l(2)gl^ts3 flies increases the frequency of defective bristle formation to 33% and 64% respectively (compared to 28% in l(2)gl⁴/l(2)gl^ts3 mutants).

(Ogawa et al., 2009)

mts⁰²⁴⁹⁶/+ has little effect on the eye phenotype of animals expressing foxo^GS9928 under the control of Scer\GAL4^GMR.PF.

mts⁰²⁴⁹⁶/+ suppresses the eye phenotype of animals expressing wdb^GS9548 and foxo^GS9928 under the control of Scer\GAL4^GMR.PF.

(Vereshchagina et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

mts^s5286

(BDGP Project Members, 1994-1999)

mts^k06009