FlyBase Allele Report: Dmel\twin[KK108897]

General Information

Symbol

Dmel\twin^KK108897

Species

D. melanogaster

Name

FlyBase ID

FBal0235908

Feature type

allele

Associated gene

Dmel\twin

Associated Insertion(s)

Carried in Construct

P{KK108897}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108897}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108897

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA with Delta^UAS.cDa

(Vicente et al., 2018)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage, with Scer\GAL4^ey.PH

(Vicente et al., 2018)

decreased occurrence of cell division | larval stage, with Scer\GAL4^ey.PH

(Vicente et al., 2018)

Phenotype Manifest In

eye, with Scer\GAL4^ey.PH

(Vicente et al., 2018)

eye disc, with Scer\GAL4^ey.PH

(Vicente et al., 2018)

Detailed Description

Statement

Reference

The expression of twin^KK108897 under the control of Scer\GAL4^ey.PH induces a highly frequent small rough eye phenotype. The eye disc exhibits a significant decrease in cell divisions (pH3 immunostaining), as compared to controls.

(Vicente et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Delta^UAS.cDa, Scer\GAL4^ey.PH, twin^KK108897 has visible | adult stage phenotype, suppressible | partially by Fancl^GD7835, Scer\GAL4^ey.PH

(Vicente et al., 2018)

Delta^UAS.cDa, Scer\GAL4^ey.PH, twin^KK108897 has visible | adult stage phenotype, suppressible | partially by Df(1)os^o

(Vicente et al., 2018)

Delta^UAS.cDa, Scer\GAL4^ey.PH, twin^KK108897 has visible | adult stage phenotype, suppressible | partially by CycB²

(Vicente et al., 2018)

Delta^UAS.cDa, Scer\GAL4^ey.PH, twin^KK108897 has neoplasia | adult stage phenotype, suppressible | partially by Df(1)os^o

(Vicente et al., 2018)

Delta^UAS.cDa, Scer\GAL4^ey.PH, twin^KK108897 has neoplasia | adult stage phenotype, suppressible | partially by Fancl^GD7835, Scer\GAL4^ey.PH

(Vicente et al., 2018)

Delta^UAS.cDa, Scer\GAL4^ey.PH, twin^KK108897 has neoplasia | adult stage phenotype, suppressible | partially by upd3^Δ/upd2^Δ

(Vicente et al., 2018)

Delta^UAS.cDa, Scer\GAL4^ey.PH, twin^KK108897 has neoplasia | adult stage phenotype, suppressible | partially by CycB²

(Vicente et al., 2018)

Delta^UAS.cDa, Scer\GAL4^ey.PH, twin^KK108897 has neoplasia | adult stage phenotype, suppressible | partially by CycB^HMS01015, Scer\GAL4^ey.PH

(Vicente et al., 2018)

Delta^UAS.cDa, Scer\GAL4^ey.PH, twin^KK108897 has visible | adult stage phenotype, suppressible | partially by upd3^Δ

(Vicente et al., 2018)

Delta^UAS.cDa, Scer\GAL4^ey.PH, twin^KK108897 has neoplasia | adult stage phenotype, suppressible | partially by upd3^Δ

(Vicente et al., 2018)

Delta^UAS.cDa, Scer\GAL4^ey.PH, twin^KK108897 has visible | adult stage phenotype, suppressible | partially by upd3^Δ/upd2^Δ

(Vicente et al., 2018)

Delta^UAS.cDa, Scer\GAL4^ey.PH, twin^KK108897 has visible | adult stage phenotype, suppressible | partially by CycB^HMS01015, Scer\GAL4^ey.PH

(Vicente et al., 2018)

Enhancer of

Statement

Reference

twin^KK108897, Scer\GAL4^ey.PH is an enhancer of neoplasia | adult stage phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH

(Vicente et al., 2018)

twin^KK108897, Scer\GAL4^ey.PH is an enhancer of visible | adult stage phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH

(Vicente et al., 2018)

Other

Statement

Reference

Delta^UAS.cDa, Scer\GAL4^ey.PH, twin^KK108897 has visible | adult stage phenotype

(Vicente et al., 2018)

Delta^UAS.cDa, Scer\GAL4^ey.PH, twin^KK108897 has neoplasia | adult stage phenotype

(Vicente et al., 2018)

Phenotype Manifest In

Suppressed by

Statement

Reference

Delta^UAS.cDa, Scer\GAL4^ey.PH, twin^KK108897 has eye phenotype, suppressible | partially by upd3^Δ

(Vicente et al., 2018)

Delta^UAS.cDa, Scer\GAL4^ey.PH, twin^KK108897 has eye phenotype, suppressible | partially by CycB²

(Vicente et al., 2018)

Delta^UAS.cDa, Scer\GAL4^ey.PH, twin^KK108897 has eye phenotype, suppressible | partially by upd3^Δ/upd2^Δ

(Vicente et al., 2018)

Delta^UAS.cDa, Scer\GAL4^ey.PH, twin^KK108897 has eye phenotype, suppressible | partially by Fancl^GD7835, Scer\GAL4^ey.PH

(Vicente et al., 2018)

Delta^UAS.cDa, Scer\GAL4^ey.PH, twin^KK108897 has eye phenotype, suppressible | partially by Df(1)os^o

(Vicente et al., 2018)

Delta^UAS.cDa, Scer\GAL4^ey.PH, twin^KK108897 has eye phenotype, suppressible | partially by CycB^HMS01015, Scer\GAL4^ey.PH

(Vicente et al., 2018)

Enhancer of

Statement

Reference

twin^KK108897, Scer\GAL4^ey.PH is an enhancer of eye phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH

(Vicente et al., 2018)

Other

Statement

Reference

Delta^UAS.cDa, Scer\GAL4^ey.PH, twin^KK108897 has eye phenotype

(Vicente et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v104442

P{KK108897}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

twin^KK108897

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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