FB2025_01 , released February 20, 2025
Allele: Dmel\Toll-7C993Y.UAS.Tag:FLAG
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General Information
Symbol
Dmel\Toll-7C993Y.UAS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0295835
Feature type
allele
Associated gene
Dmel\Toll-7
Associated Insertion(s)
Carried in Construct
P{UAS-Toll-7.CY}
Also Known As
UAS-Toll-7CY
Key Links
Transgenic product class
missense_variant
(McIlroy et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(McIlroy et al., 2013)
Mutagen
in vitro construct
(McIlroy et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-Toll-7.CY}
Cytology
Description

Amino acid replacement: C993Y.

(McIlroy et al., 2013)

UAS regulatory sequences drive expression of mutated Toll-7 coding sequences.

(McIlroy et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Toll-7
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  carcinoma
      modeled by scribGD11666
      (Ding et al., 2022)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Toll-7C993Y.UAS.Tag:FLAG under the control of Scer\GAL4ptc-559.1 induces expansion of, and increased mitosis in, the ptc domain along the anterior-posterior compartment boundary of the third instar larval wing disc; some Toll-7C993Y.UAS.Tag:FLAG expressing cells are basally extruded and migrate away from the anterior-posterior compartment boundary.

      (Ding et al., 2022)

      Expression of Toll-7C993Y.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4elav.PU results in significantly increased number of eve-positive neurons in the ventral nerve cord in third instar larvae, as compared to driver-only controls.

      (Foldi et al., 2017)

      Constitutive overexpression of Toll-6, through expression of Toll-7C993Y.Scer\UAS.T:Zzzz\FLAG in the neurons, under the control of Scer\GAL4elav-C155, causes axon targeting defects. Neuronal apoptosis is rescued in these overexpression mutants.

      (McIlroy et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Pan-neuronal expression of Toll-7C993Y.Scer\UAS.T:Zzzz\FLAG, under the control of Scer\GAL4elav-C155, suppresses the semi-lethality seen in spz2 mutants.

      (McIlroy et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Toll-7C993Y.Scer\UAS.T:Zzzz\FLAG
      Toll-7C993Y.UAS.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (3)