Reference Report

Reference
Citation	Royet, J., Finkelstein, R. (1996). hedgehog, wingless and orthodenticle specify adult head development in Drosophila. Development 122(6): 1849--1858. (Export to RIS)
FlyBase ID	FBrf0088886
Publication Type	Research paper
PubMed ID	8674424
PubMed Abstract	The adult head capsule of Drosophila forms primarily from the eye-antennal imaginal discs. Here, we demonstrate that the head primordium is patterned differently from the discs which give rise to the appendages. We show that the segment polarity genes hedgehog and wingless specify the identities of specific regions of the head capsule. During eye-antennal disc development, hedgehog and wingless expression initially overlap, but subsequently segregate. This regional segregation is critical to head specification and is regulated by the orthodenticle homeobox gene. We also show that orthodenticle is a candidate hedgehog target gene during early eye-antennal disc development.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	T(1;2)ocγ1
Alleles (15)
	dsh⁶ Ecol\lacZ^17.6.L1 Ecol\lacZ^en-Xho25 Ecol\lacZ^hh-P30 Ecol\lacZ^neur-A101 Ecol\lacZ^wg-en11 fu¹ hh^{Scer\FRT.αTub84B} hh^ts2 hh^αTub84B.PB oc^γa1 wg^Act5C.PS wg^l-12 wg^l-16 wg^{Scer\FRT.Act5C}
Constructs (5)
	P{17.6(L1)-lacZ} P{Act5C(FRT.y⁺)wg.S} P{Act5C(-FRT)wg.S} P{αTub84B(FRT.y⁺)hh.B} P{αTub84B(-FRT)hh.B}
Genes (6)
	dsh Ecol\lacZ fu hh oc wg
Insertions (4)
	P{en1}wg^en11 P{en-lacZ(Xho)}en^Xho25 P{lArB}neur^A101 P{PZ}hh^P30