FlyBase Allele Report: Dmel\Antp[1]

General Information

Symbol

Dmel\Antp¹

Species

D. melanogaster

Name

FlyBase ID

FBal0000542

Feature type

allele

Associated gene

Dmel\Antp

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

hypomorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Simon et al., 1992)

hypomorphic allele - genetic evidence

Mutagen

X ray

(Abbott and Kaufman, 1986)

Progenitor genotype

Cytology

Polytene chromosomes normal.

Description

Defective in promoter P2 function.

(Talbert and Garber, 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Simon et al., 1992)

lethal (with Antp^Scx)

(Southworth and Kennison, 2002)

lethal | recessive

(Talbert and Garber, 1994)

lethal - all die before end of P-stage | recessive

(Abbott and Kaufman, 1986)

some die during immature adult stage | recessive

(Simon et al., 1992)

some die during pharate adult stage | recessive

(Abbott and Kaufman, 1986)

viable (with Antp¹⁷)

(Southworth and Kennison, 2002)

viable (with Antp^73b)

(Southworth and Kennison, 2002)

viable (with Antp^B)

(Southworth and Kennison, 2002)

viable (with Antp^CB)

(Southworth and Kennison, 2002)

viable (with Antp^Ctx)

(Southworth and Kennison, 2002)

viable (with Antp^LC)

(Southworth and Kennison, 2002)

viable (with Antp^PW)

(Southworth and Kennison, 2002)

viable (with Antp^R)

(Southworth and Kennison, 2002)

Phenotype Manifest In

muscle cell of mesothoracic dorsal acute muscle 3

(Enriquez et al., 2010)

muscle cell of metathoracic dorsal acute muscle 3

(Enriquez et al., 2010)

prothoracic leg

(Abbott and Kaufman, 1986)

Detailed Description

Statement

Reference

No DA3 muscle forms in thoracic segment 2 and 3 in Antp¹ embryos.

(Enriquez et al., 2010)

No ectopic abd-A or Abd-B expression is seen.

(Simon et al., 1992)

Pharate adult individuals have normal mesothoracic and metathoracic legs but abnormal prothoracic legs: fusion of the femur, tibia and tarsal leg segments. Failure to eclose from the pupal case is most likely due to a mechanical difficulty derived from the dramatic crippling of the prothoracic legs.

(Abbott and Kaufman, 1986)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The penetrance of the held-out wing phenotype in Antp¹/Antp^B flies is increased if they are also heterozygous for brm².