FlyBase Allele Report: Dmel\Dll[9]

General Information

Symbol

Dmel\Dll⁹

Species

D. melanogaster

Name

FlyBase ID

FBal0001006

Feature type

allele

Associated gene

Dmel\Dll

Associated Insertion(s)

Carried in Construct

Also Known As

Ba^M, Dll^M

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Cohen and Jurgens, 1989)

Mutagen

spontaneous

(Cohen and Jurgens, 1989, Sunkel and Whittle, 1987)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Sunkel and Whittle, 1987)

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

homeotic (with Dll^md23)

(Dey et al., 2009)

lethal (with Dll^md23)

(Dey et al., 2009)

viable

(Sunkel and Whittle, 1987)

visible | recessive

(Sunkel and Whittle, 1987)

Phenotype Manifest In

antenna

(Sunkel and Whittle, 1987)

antenna (with Dll^md23)

(Dey et al., 2009)

tarsal segment (with Dll^md23)

(Dey et al., 2009)

tarsal segment | ectopic

tibia

unguis

unguis | ectopic

Detailed Description

Statement

Reference

About 3% of Dll^md23/Dll⁹ animals emerge as adults, with all escapers displaying partial transformation of the antenna to leg structures and deletion of distal leg structures.

(Dey et al., 2009)

Homozygote has a very mild leg phenotype: males have a decrease in number of sex comb teeth. Entire arista and distal most portion of AIII are transformed into a distally complete tarsus.

(Cohen and Jurgens, 1989)

Minor reductions in the tarsal region.

(Cohen et al., 1989)

Heterozygotes are wild-type. Homozygotes show a transformation of antenna to leg. Hemizygous embryos but not homozygous embryos lack the Keilin's organs, and sometimes lack the labial sense organ, antennal sense organ and maxillary sense organ.

(Sunkel and Whittle, 1987)

Homozygotes show partial transformation of antennae to legs as well as deletions of some leg structures. Tarsal tissue, sometimes including claws, develops in place of arista and part of third antennal segment. Third segment usually contains patchwork of incompletely differentiated leg tissue; first and second segments normal. Leg effects distal to mid-tibia; legs proximal to mid-tibia normal. In extreme cases number of tarsal segments reduced to two or three; basitarsus and distal tibia may be missing; in most extreme cases claws may also be missing. In the case of mild expression abnormal bristle patterns, including polarity reversal, occur around basitarsus-tibia joint, where there may also develop cuticular hyperplasia. Penetrance greater in females than males, in antennae than legs and in metathoracic than other legs.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Dll⁹/Dll^md23 has lethal phenotype, enhanceable by disco^RNAi.UAS/Scer\GAL4^Dll-md23

(Dey et al., 2009)

Suppressed by

Statement

Reference

Dll⁹/Dll^md23 has lethal phenotype, suppressible | partially by disco^UAS.cDa/Scer\GAL4^Dll-md23

(Dey et al., 2009)

Dll⁹/Dll^md23 has homeotic phenotype, suppressible | partially by disco^UAS.cDa/Scer\GAL4^Dll-md23

(Dey et al., 2009)

Enhancer of

Statement

Reference

Dll⁹/Dll[+] is an enhancer of increased cell death phenotype of Dref^UAS.cSa, Scer\GAL4^GMR.PS

(Hirose et al., 2001)

Dll⁹/Dll[+] is an enhancer of visible phenotype of BEAF-32^UAS.cYa, Scer\GAL4^GMR.PS

(Yamaguchi et al., 2001)

Suppressor of

Statement

Reference

Dll⁹ is a suppressor | partially of lethal phenotype of Nf-YA^UAS.Tag:HA, Scer\GAL4^ey.PH

(Yoshioka et al., 2007)

Phenotype Manifest In

Suppressed by

Statement

Reference

Dll⁹/Dll^md23 has antenna phenotype, suppressible | partially by disco^UAS.cDa/Scer\GAL4^Dll-md23

(Dey et al., 2009)

Dll⁹/Dll^md23 has tarsal segment phenotype, suppressible | partially by disco^UAS.cDa/Scer\GAL4^Dll-md23

(Dey et al., 2009)

Enhancer of

Statement

Reference

Dll⁹/Dll[+] is an enhancer of eye phenotype of Dref^UAS.cSa, Scer\GAL4^GMR.PS

(Hirose et al., 2001)

Dll⁹ is an enhancer of eye phenotype of BEAF-32^UAS.cYa, Scer\GAL4^GMR.PS

(Yamaguchi et al., 2001)

NOT Enhancer of

Statement

Reference

Dll⁹/Dll[+] is a non-enhancer of wing vein | ectopic phenotype of Snr1^E1

(Marenda et al., 2004)

NOT Suppressor of

Statement

Reference

Dll⁹/Dll[+] is a non-suppressor of wing vein | ectopic phenotype of Snr1^E1

(Marenda et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Scer\GAL4^Dll-md23-mediated expression of disco^Scer\UAS.cDa partially rescues the lethality associated with Dll^md23/Dll⁹, and nearly completely rescues the antenna and leg phenotypes of this mutant.

Scer\GAL4^Dll-md23-mediated expression of disco^{dsRNA.Scer\UAS} reduces the number of Dll^md23/Dll⁹ escapers to nearly zero.

(Dey et al., 2009)

Dll⁹ flies expressing Nf-YA^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^ey.PH show 86% viability.

(Yoshioka et al., 2007)

Genetic crossing of the Dref^Scer\UAS.cSa expressing strain with Dll⁹ results in a weakly enhanced rough eye phenotype.

(Hirose et al., 2001)

The rough eye phenotype caused by expression of BEAF-32^Scer\UAS.cYa under the control of Scer\GAL4^GMR.PS is weakly enhanced by Dll⁹.

(Yamaguchi et al., 2001)

Has little or no effect on the phenotype of E2f^GMR.PD Dp^GMR.PD BacA\p35^GMR.PH flies.

(Staehling-Hampton et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

3069

106818

Notes on Origin

Discoverer

Sato.

Comments

Weak Dll allele.

(Cohen et al., 1989)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Ba⁹

(Lindsley and Zimm, 1992)

Ba^M

(Goriely et al., 1996, Lindsley and Zimm, 1992, Sunkel and Whittle, 1987)

Dll⁹

(Dey et al., 2009, Yoshioka et al., 2007, Hirose et al., 2001)

Dll^M

(Cohen and Jurgens, 1989, Cohen et al., 1989)

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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