FlyBase Allele Report: Dmel\RpLP0[01544]

General Information

Symbol

Dmel\RpLP0⁰¹⁵⁴⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0009416

Feature type

allele

Associated gene

Dmel\RpLP0

Associated Insertion(s)

P{PZ}RpLP0⁰¹⁵⁴⁴

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypermorphic allele - genetic evidence

gain of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

gain of function allele

(Frolov and Birchler, 1998)

hypermorphic allele - genetic evidence

(Frolov and Birchler, 1998)

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}RpLP0⁰¹⁵⁴⁴

Cytology

Description

P{PZ} maps to the first intron of RpLP0.

(Frolov and Birchler, 1998)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:22,076,133..22,076,133 [+]

(Spradling et al., 1999, Frolov and Birchler, 1998, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999, Frolov and Birchler, 1998)

suppressor of variegation | dominant, with In(1)w^m4h

(Frolov and Birchler, 1998)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

RpLP0⁰¹⁵⁴⁴/RpLP0[+] is an enhancer of visible phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

NOT Suppressor of

Statement

Reference

RpLP0⁰¹⁵⁴⁴/RpLP0[+] is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS

(Ambegaokar and Jackson, 2011)

Phenotype Manifest In

Enhancer of

Statement

Reference

RpLP0⁰¹⁵⁴⁴/RpLP0[+] is an enhancer of eye phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

RpLP0⁰¹⁵⁴⁴ is an enhancer of pigment cell phenotype of w^sp3

(Frolov and Birchler, 1998)

RpLP0⁰¹⁵⁴⁴ is an enhancer of pigment cell phenotype of w^sp1

(Frolov and Birchler, 1998)

RpLP0⁰¹⁵⁴⁴ is an enhancer of pigment cell phenotype of w^sp55

(Frolov and Birchler, 1998)

RpLP0⁰¹⁵⁴⁴ is an enhancer of pigment cell phenotype of w^sp81d

(Frolov and Birchler, 1998)

Suppressor of

Statement

Reference

RpLP0⁰¹⁵⁴⁴ is a suppressor of pigment cell phenotype of w^crr

(Frolov and Birchler, 1998)

RpLP0⁰¹⁵⁴⁴ is a suppressor of pigment cell phenotype of w^a2

(Frolov and Birchler, 1998)

RpLP0⁰¹⁵⁴⁴ is a suppressor of pigment cell phenotype of w^bl

(Frolov and Birchler, 1998)

RpLP0⁰¹⁵⁴⁴ is a suppressor of pigment cell phenotype of w^col

(Frolov and Birchler, 1998)

RpLP0⁰¹⁵⁴⁴ is a suppressor of pigment cell phenotype of w^a

(Frolov and Birchler, 1998)

RpLP0⁰¹⁵⁴⁴ is a suppressor of pigment cell phenotype of w^cf

(Frolov and Birchler, 1998)

NOT Suppressor of

Statement

Reference

RpLP0⁰¹⁵⁴⁴/RpLP0[+] is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS

(Ambegaokar and Jackson, 2011)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of RpLP0⁰¹⁵⁴⁴ does not suppress the apoptosis seen in flies overexpressing hid.

(Ambegaokar and Jackson, 2011)

Xenogenetic Interactions

Statement

Reference

One copy of RpLP0⁰¹⁵⁴⁴ enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of RpLP0⁰¹⁵⁴⁴ does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

(Ambegaokar and Jackson, 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11537

P{PZ}RpLP0⁰¹⁵⁴⁴ ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

A. Spradling.

Comments

Δ2-3 induced mobilisation of the P{PZ} can revert the mutant phenotype to wild type.

(Frolov and Birchler, 1998)

Complements: Aats-ile⁰⁰⁸²⁷. Complements: TyrR^neo30.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

P0^l(3)01544

(Frolov and Birchler, 1998)

RpLP0⁰¹⁵⁴⁴

(Ambegaokar and Jackson, 2011, Gresens and Cook, 2006.12.5)

RpP0⁰¹⁵⁴⁴

(BDGP Project Members, 1994-1999)

l(3)01544

(Spradling et al., 1999)

l(3)01544⁰¹⁵⁴⁴

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

Open Close