FlyBase Allele Report: Dmel\fry[02240]

(Han et al., 2012, Cong et al., 2001, Spradling, 1999.12.9, Spradling et al., 1999, Neufeld et al., 1998, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates tauopathy

modeled by Hsap\MAPT^V337M.UAS

(Shulman and Feany, 2003)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage (with fry¹)

(Han et al., 2012)

lethal | recessive

(Cong et al., 2001, Spradling et al., 1999, BDGP Project Members, 1994-1999)

visible

(He and Adler, 2002)

visible (with fry⁷)

(He and Adler, 2002)

Phenotype Manifest In

adult abdomen & chaeta

(Cong et al., 2001)

adult head bristle

(Cong et al., 2001)

arista

(He and Adler, 2002, Cong et al., 2001)

arista (with fry⁷)

(He and Adler, 2002)

larval dorsal multidendritic neuron ddaC | third instar larval stage (with fry¹)

(Han et al., 2012)

leg & chaeta

(Cong et al., 2001)

mesothoracic tergum & chaeta

(Cong et al., 2001)

multidendritic neuron & dendrite

(Emoto et al., 2004)

multidendritic neuron & dendrite (with fry¹)

(Emoto et al., 2004)

multidendritic neuron & dendrite | supernumerary

(Emoto et al., 2004)

multidendritic neuron & dendrite | supernumerary (with fry¹)

(Emoto et al., 2004)

triple row of wing sensilla

(Cong et al., 2001)

wing hair | increased number

(Cong et al., 2001)

Detailed Description

Statement

Reference

fry¹/fry⁰²²⁴⁰ mutant third instar larvae show a significant increase in the proportion of dorsal midline ddaC dendritic length that is enclosed within the epidermis rather than attached to the ECM. Dendrite crossing is seen in these mutants, and the majority of these crossings are between enclosed dendrites and dendrites attached to the ECM and are thus non-contacting. Unlike in wild type, crossing is also seen between dendrites on the interface between the v'ada and the vdaB neurons. These crossings are non-contacting.

(Han et al., 2012)

fry⁰²²⁴⁰ mutants exhibit supernumerary terminal branching and defective dendritic tiling: the branches of ddaC neurons often overlap each other. ddaC neurons in fry⁰²²⁴⁰/fry¹ larvae exhibit tiling defects, though they have normal dendritic length and branch points.

(Emoto et al., 2004)

The length of the central core of the arista is reduced in fry⁰²²⁴⁰/fry⁷ flies and the arista laterals are branched. Homozygous flies have split arista laterals.

(He and Adler, 2002)

Homozygotes often die as pharate adults. Cells in the wing of pharate adults form a cluster of hairs. The multiple wing hair phenotype is also seen in pupae late in hair development (more than 36 hours after the white pupa stage), while at earlier times the phenotype seems weaker. One or a few branched bristles are seen in the abdomen, legs, notum and triple row of homozygous pharate adults. These bristles are relatively normal in shape and length except for the branching. In some cases, several branches are seen at the same proximal/distal location along the shaft. Bristles with extensive splitting are occasionally seen and these are often shorter than normal. On the head, some bristles are bent, distorted and shorter than normal without being excessively split. The phenotype of developing bristles in the pupa (assayed by staining the actin cytoskeleton) overlaps that of the adult bristle phenotype. Homozygous or hemizygous pharate adults show extensive branching of essentially all arista laterals and they are thinner than normal and appear curled distally. Equivalent defects are seen in developing arista laterals in pupae.

(Cong et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

fry⁰²²⁴⁰/fry¹ has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by mew^UAS.cMBa/mys^UAS.cDa/Scer\GAL4^ppk.PH

(Han et al., 2012)

Suppressor of

Statement

Reference

fry⁰²²⁴⁰ is a suppressor of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Other

Statement

Reference

fry⁰²²⁴⁰, stan[+]/stan^E59 has abnormal neuroanatomy | third instar larval stage phenotype

(Matsubara et al., 2011)

Phenotype Manifest In

Suppressed by

Statement

Reference

fry⁰²²⁴⁰/fry¹ has larval dorsal multidendritic neuron ddaC | third instar larval stage phenotype, suppressible by mew^UAS.cMBa/mys^UAS.cDa/Scer\GAL4^ppk.PH

(Han et al., 2012)

Suppressor of

Statement

Reference

fry⁰²²⁴⁰ is a suppressor of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

fry⁰²²⁴⁰ is a suppressor of ommatidium phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Other

Statement

Reference

fry⁰²²⁴⁰, stan[+]/stan^E59 has dendrite | third instar larval stage phenotype

(Matsubara et al., 2011)

fry⁰²²⁴⁰, stan[+]/stan^E59 has larval dorsal multidendritic neuron ddaC | third instar larval stage phenotype

(Matsubara et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of mys^Scer\UAS.cDa and mew^{Scer\UAS.cMBa} the control of Scer\GAL4^ppk.PH rescues the increase in epidermally enclosed dendrites seen in fry¹/fry⁰²²⁴⁰ mutants. The dendritic crossing seen in fry¹/fry⁰²²⁴⁰ mutants is also largely rescued. The dendritic crossings that remain in the rescue flies are between two ECM attached dendrites, rather than non-contacting crossings between an epidermally enclosed dendrite and one attached to the ECM. The crossing on the v'ada/vdaB interface is also mostly rescued and all non-contacting crossing is eliminated.

(Han et al., 2012)

stan^E59/fry⁰²²⁴⁰ double heterozygous larvae show increased crossing of dendrites in the dendritic arbor of the ddaC class IV neurons compared to wild type (neither single heterozygote shows this phenotype).

(Matsubara et al., 2011)

Xenogenetic Interactions

Statement

Reference

The rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is suppressed by fry⁰²²⁴⁰.

(Shulman and Feany, 2003)

Complementation and Rescue Data

Fails to complement

fry^unspecified

(Neufeld et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11558

P{PZ}fry⁰²²⁴⁰ ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

A. Spradling.

Comments

Excision of the P{PZ} element can revert the mutant phenotype.

(Cong et al., 2001)

Complements: simj⁰¹⁸¹⁴. Complements: cpo⁰¹⁸²⁴. Complements: l(3)01859⁰¹⁸⁵⁹. Complements: l(3)rK145^rK145.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

fry⁰²²⁴⁰

(Christensen et al., 2008.12.28, Christensen et al., 2007.10.29)

fry⁶

(Han et al., 2012, Matsubara et al., 2011, Emoto et al., 2004, He and Adler, 2002, Cong et al., 2001)

l(3)02240

(Cong et al., 2001, Spradling, 1999.12.9, Spradling et al., 1999)

l(3)02240⁰²²⁴⁰

(BDGP Project Members, 1994-1999)

l(3)2240

(Neufeld et al., 1998)

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

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