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General Information
Symbol
Dmel\Hsc70-403550
Species
D. melanogaster
Name
FlyBase ID
FBal0009472
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
l(3)03550
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The P{PZ} insertion is within the first exon of Hsc70-4 just after the proposed transcription start site.

Insertion components
P{PZ}Hsc70-403550
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The nerve-evoked excitatory junctional potential (EJP) amplitudes in mutant larvae are reduced to about half that of controls. EJP amplitudes are not reduced by a fatigue of evoked release, because responses sequentially recorded at 0.2 Hz do not progressively diminish. The quantal content of evoked release in homozygotes is reduced to a third to a half of control.

Shows no interaction with N pathway mutants.

Third instar larvae contain circulating melanotic capsules, and die as early pupae.

The Bolwig's organs show variable disruption of cell clustering in homozygous embryos. A number of photoreceptors are displaced along the path of the Bolwig's nerve (BN) in some embryos. The BN defasciculates on the surface of the optic lobe anlagen in most embryos. the defasciculated BN usually projects abnormally and forms loop-like structures.

Germline clones produce eggs with patterning defects: anterior head defects and variable abdominal segmentation defects. Lethality occurs during the larval and pupal stages.

visible rough eyes, bent wings, thin, short bristles

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

Hsc70-403550/Hsc70-4[+] is an enhancer of visible | dominant | homeotic phenotype of Pc3

NOT Enhancer of
Statement
Reference
NOT Suppressor of
Statement
Reference
Other
Phenotype Manifest In
NOT Enhanced by
Statement
Reference

Hsc70-403550 has axon | larval stage phenotype, non-enhanceable by CspU1

NOT suppressed by
Statement
Reference

Hsc70-403550 has axon | larval stage phenotype, non-suppressible by CspU1

Enhancer of
Statement
Reference

Hsc70-403550/Hsc70-4[+] is an enhancer of wing vein | ectopic phenotype of Snr1E1

Hsc70-403550/Hsc70-4[+] is an enhancer of sex comb | ectopic phenotype of ph-p410

Hsc70-403550/Hsc70-4[+] is an enhancer of sex comb | ectopic phenotype of Pc3

NOT Enhancer of
Statement
Reference

Hsc70-403550 is a non-enhancer of axon | larval stage phenotype of CspU1

Hsc70-403550/Hsc70-4[+] is a non-enhancer of adult abdominal segment 5 phenotype of trxB11

Hsc70-403550/Hsc70-4[+] is a non-enhancer of abdominal tergite 4 | male phenotype of Pc3

Hsc70-403550/Hsc70-4[+] is a non-enhancer of abdominal tergite 6 phenotype of Pc3

Hsc70-403550/Hsc70-4[+] is a non-enhancer of adult abdominal segment 4 phenotype of Pc3

Hsc70-403550/Hsc70-4[+] is a non-enhancer of adult abdominal segment 5 | ectopic phenotype of Pc3

Hsc70-403550/Hsc70-4[+] is a non-enhancer of adult abdominal segment 6 phenotype of Pc3

Hsc70-403550/Hsc70-4[+] is a non-enhancer of adult abdominal segment 7 | ectopic phenotype of Pc3

Suppressor of
Statement
Reference

Hsc70-403550 is a suppressor | partially of eye phenotype of CycEJP

NOT Suppressor of
Statement
Reference

Hsc70-403550 is a non-suppressor of axon | larval stage phenotype of CspU1

Additional Comments
Genetic Interactions
Statement
Reference

The CycEJP rough eye phenotype is weakly suppressed by the addition of Hsc70-403550.

The EJP amplitudes recorded from Hsc70-403550, CspU1 double mutant neuromuscular junctions (NMJs) are reduced to about a third of control amplitudes - about the same as each allele individually. The frequency and amplitude of spontaneously occurring mEJPs in double mutants are not different from controls.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

A. Spradling.

Comments
Comments

Excision of the P{PZ} restores wild type phenotype.

Complements: l(3)0071600716. Complements: Tm102299. Complements: l(3)0471304713. Complements: Tm109965. Complements: Tm110617. Complements: MRG15j6A3. Complements: l(3)neo431.

The lethality and Bolwig's nerve disruption phenotype can be reverted by P-element excision.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
Reported As
Symbol Synonym
E(nd)195ry+3550
Hsc70-403550
Hsc70-4P03550
l(3)0355003550
scattered03550
Name Synonyms
Secondary FlyBase IDs
    References (15)