FlyBase Allele Report: Dmel\Ras85D[06677]

General Information

Symbol

Dmel\Ras85D⁰⁶⁶⁷⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0009572

Feature type

allele

Associated gene

Dmel\Ras85D

Associated Insertion(s)

P{PZ}Ras85D⁰⁶⁶⁷⁷

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}Ras85D⁰⁶⁶⁷⁷

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:9,512,366..9,512,366 [+]

(Park et al., 2013, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN1^82Q.UAS

(Park et al., 2013)

ameliorates multiple endocrine neoplasia type 2B

modeled by Ret^MEN2B.GMR

(Read et al., 2005)

ameliorates multiple endocrine neoplasia type 2A

modeled by Ret^MEN2A.GMR

(Read et al., 2005)

ameliorates alveolar rhabdomyosarcoma

modeled by Hsap\FOXO1::Hsap\PAX7^UAS.cGa

(Galindo et al., 2006)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999)

partially lethal - majority die

partially lethal - majority die | recessive

(Berkeley Drosophila Genome Project, 1993.6.1)

visible | recessive

(Berkeley Drosophila Genome Project, 1993.6.1)

Phenotype Manifest In

abdominal tergite

(Berkeley Drosophila Genome Project, 1993.6.1)

Detailed Description

Statement

Reference

Homozygotes have etched tergites.

(Berkeley Drosophila Genome Project, 1993.6.1)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Ras85D⁰⁶⁶⁷⁷ is a suppressor | partially of abnormal locomotor behavior phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS

(Park et al., 2013)

Ras85D⁰⁶⁶⁷⁷ is a suppressor | partially of short lived phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^nrv2.PS

(Park et al., 2013)

Ras85D⁰⁶⁶⁷⁷ is a suppressor of visible | adult stage phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Park et al., 2013)

Ras85D⁰⁶⁶⁷⁷/Ras85D[+] is a suppressor of lethal phenotype of Hsap\FOXO1::Hsap\PAX7^UAS.cGa, Scer\GAL4^Mhc.PW

(Galindo et al., 2006)

Ras85D⁰⁶⁶⁷⁷ is a suppressor of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

Ras85D⁰⁶⁶⁷⁷ is a suppressor of visible phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

Phenotype Manifest In

Suppressor of

Statement

Reference

Ras85D⁰⁶⁶⁷⁷ is a suppressor of eye phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Park et al., 2013)

Ras85D⁰⁶⁶⁷⁷ is a suppressor of photoreceptor phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Park et al., 2013)

Ras85D⁰⁶⁶⁷⁷/Ras85D[+] is a suppressor of larval muscle system phenotype of Hsap\FOXO1::Hsap\PAX7^UAS.cGa, Scer\GAL4^Mhc.PW

(Galindo et al., 2006)

Ras85D⁰⁶⁶⁷⁷/Ras85D[+] is a suppressor of larval somatic muscle cell phenotype of Hsap\FOXO1::Hsap\PAX7^UAS.cGa, Scer\GAL4^Mhc.PW

(Galindo et al., 2006)

Ras85D⁰⁶⁶⁷⁷ is a suppressor of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

Ras85D⁰⁶⁶⁷⁷ is a suppressor of eye phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Ras85D⁰⁶⁶⁷⁷ partially suppresses the external eye phenotype and photoreceptor degeneration seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF. The progressive impairment of motor performance and reduction in lifespan seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^nrv2.PS are also partially rescued.

(Park et al., 2013)

Heterozygosity for Ras85D^e2F, Ras85D^e1B or Ras85D⁰⁶⁶⁷⁷ suppresses the larval muscle phenotype seen in animals expressing Hsap\FOXO1A::Hsap\PAX7^Scer\UAS.cGa under the control of Scer\GAL4^Mhc.PW and also results in viable adult escapers.

(Galindo et al., 2006)

Complementation and Rescue Data

Fails to complement

Ras85D^s1747

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11694

P{PZ}Ras85D⁰⁶⁶⁷⁷ ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

A. Spradling.

Comments

Complements: pum⁰¹⁶⁸⁸. Complements: l(3)01728⁰¹⁷²⁸. Complements: Aats-trp⁰³⁵⁵⁹. Complements: Aats-trp⁰⁴⁴¹⁰. Complements: l(3)04837⁰⁴⁸³⁷. Complements: l(3)05430⁰⁵⁴³⁰. Complements: ps¹⁰⁶¹⁵. Complements: pum¹⁰⁶²⁵. Complements: l(3)L4092^L4091.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Ras85^D06677

(Mahoney et al., 2006)

Ras85D⁰⁶⁶⁷⁷

dRas^LOF

(Park et al., 2013)

l(3)06677

(Spradling et al., 1999)

l(3)06677⁰⁶⁶⁷⁷

(Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project, 1993.6.1)

ras⁰⁶⁶⁷⁷

(Galindo et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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