FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Nnd-2
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General Information
Symbol
Dmel\Nnd-2
Species
D. melanogaster
Name
FlyBase ID
FBal0012891
Feature type
allele
Associated gene
Dmel\N
Associated Insertion(s)
Carried in Construct
Also Known As
nd2
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Couso and Martinez Arias, 1994)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Frameshift 14 residues before the C terminus, which leads to a truncated protein.

    (Couso and Martinez Arias, 1994)

    Nnd-2 maps proximal to Nnd-1 at the 3' end of Notch and shows a deletion of one bp.

    (Lindsley and Zimm, 1992)

    Deletion of 1bp from codon 2690 causing a frameshift that changes the 14 carboxy terminal amino acid into a new sequence which is 23 amino acids in length.

    (Xu et al., 1990)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Nnd-2 is a temperature-sensitive allele. In homozygous Nnd-1 mutants at 29[o]C, eyes are rough and reduced in size. They also show extreme wing notching and thickened wing veins.

        Nnd-2 mutants exhibit elevated levels of asymmetry and reduced mean character size relative to Canton-S flies for thoracic bristles.

        Nnd-2 mutants show significantly reduced mean character size for orbital bristles compared to Canton-S flies.

        (Indrasamy et al., 2000)

        Wing margin is scalloped. Wing veins are slightly thickened.

        (Royet et al., 1998)

        At 25oC, nicks in wings. At 17oC displays Ax-type phenotypes. Reduces viability and increases penetrance of wing/haltere phenotypes of wg1. N, wg1 and arm4 triple mutants display, with about 10-20% penetrance, a perfect duplication of the notum charcateristic of wg mutations.

        (Couso and Martinez Arias, 1994)

        Mutant flies have a variable mutant phenotype with a slightly increased or slightly decreased density of bristles in different regions of the thorax. Mutant cells in clones fail to prevent their wild type neighbours from becoming neural and more bristles than expected are of the wild type genotype.

        (Heitzler and Simpson, 1993)

        Thickened wing veins with deltas and variably notched wing margins.

        (Lyman and Young, 1993)

        Nnd-2/Nnd-2 and Nnd-2/Nnd-1 flies resemble Nnd-1 homozygotes; Nnd-2/Nnd-3 heterozygotes are noncomplementary (Welshons). The Nnd-2 allele is temperature-sensitive; in homozygotes at 29oC, the eyes are small and rough (spl-like), wings have extreme notches, wing veins are thickened, tarsi are shortened and the mutants are semi-lethal as late pupae; at 25oC, the abnormalities are much less severe; at 18oC, the eyes are slightly spl-like, wings are nicked, wing veins are incomplete, some bristles are missing, and the mutants are semi-lethal as late pupae. Similar wing abnormalities in Nnd-1/Y; groE73/+ and Nnd-2/Y; groE73/+ males. RK1.

        (Lindsley and Zimm, 1992)

        Nnd-1/dxENU and Nnd-2/dxENU transheterozygous flies never reach adulthood, stage not determined. Enhance wing phenotype.

        (Xu and Artavanis-Tsakonas, 1990)

        Wing notching and thickened veins when homozygous or hemizygous. Temperature sensitive rough eye phenotype at 18oC.

        (Xu et al., 1990)

        Homozygotes show late pupal semi-lethality at 18oC and 29oC. Homozygotes have small, rough eyes (like Nspl-1), extreme apical and marginal notches in the wing, thick wing veins and a shortened tarsus at 29oC. At 25oC, the Nspl-1-like eye phenotype, wing apical notching and thick wing vein phenotypes are seen. At 18oC, a weak Nspl-1-like eye phenotype, weak wing nicking, incomplete wing veins and missing bristles are seen.

        (Shellenbarger and Mohler, 1975)

        Similar to and phenotypically non-complementary with Nnd-3.

        (Welshons, 1974)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Enhanced by
        Statement
        Reference

        Nnd-2 has phenotype, enhanceable by sno71e3

        (Coyle-Thompson and Banerjee, 1993)

        Nnd-2 has eye phenotype, enhanceable by E(spl)[+]/E(spl)m8-HLH1

        (Xu et al., 1990)
        Suppressed by
        Statement
        Reference

        Nnd-2 has wing phenotype, suppressible by Nle[+]/Nlek13714

        (Royet et al., 1998)

        Nnd-2 has wing vein phenotype, suppressible by Nle[+]/Nlek13714

        (Royet et al., 1998)

        Nnd-2 has wing phenotype, suppressible by Nle[+]/NleΔ8

        (Royet et al., 1998)

        Nnd-2 has wing vein phenotype, suppressible by Nle[+]/NleΔ8

        (Royet et al., 1998)
        Enhancer of
        Statement
        Reference

        Nnd-2 is an enhancer of phenotype of sno71e3

        (Coyle-Thompson and Banerjee, 1993)
        Other
        Statement
        Reference

        E(spl)m8-HLH1, Nnd-2 has eye phenotype

        (Xu et al., 1990)

        Nnd-2, groE73 has wing phenotype

        (Xu et al., 1990)

        Nnd-2, mam10 has wing phenotype

        (Xu et al., 1990)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Synergistic interaction of phenotype with that of sno71e3 mutation.

        (Coyle-Thompson and Banerjee, 1993)

        Temperature sensitive rough eye phenotype at 18oC is enhanced by one copy of E(spl)1. When heterozygous with groE73 causes a severe wing material loss phenotype. Wing development is severely affected when heterozygous with mam10.

        (Xu et al., 1990)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        R.M. Valencia,.

        (Lindsley and Zimm, 1992)
        Comments
        Comments

        Phenotype is sensitive to specific alleles of wg. Shows weak allele-specific interaction with wgl-15 and wgS107, and strong allele-specific interaction with wgl-12 and wgS84.

        (Couso and Martinez Arias, 1994)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        References (19)