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General Information
Symbol
Dmel\oc1
Species
D. melanogaster
Name
FlyBase ID
FBal0013199
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The eclosion of oc1 mutant flies under photoperiod conditions lacks the prominent lights-on response seen in wild-type flies. No significant increases in eclosion are seen regardless of when flies are exposed to the lights-on signal. The eclosion rate is variable and substantial eclosion precedes the lights-on signal, but overall eclosion appears circadian. Flies exhibit normal geotaxis. The time taken for the flies to spread their wings post-eclosion is similar in flies that eclose in the dark and those that eclose in response to the lights-on signal. This is in contrast to controls, in which inflation occurs more quickly in the dark.

oc1 males do not show feminisation of walking behaviour; the number of start/stop bouts is not greater than in control males.

Homozygotes and hemizygotes lack ocelli and most of the associated bristles.

The entire protocerebral bridge is missing in oc1 adult brains. Total walking activity is significantly decreased in comparison to wild-type flies. Episodes of high walking probability occur as frequently as in wild-type flies, but these episodes are of much shorter duration than in wild type.

Homozygotes and hemizygotes lack the ocelli and most of the associated bristles.

Transheterozygous larvae with lphA2 have a low negatively photokinetic stimulus indice.

Defects in formation of the protocerebral bridge.

In hemizygotes the ocelli, the interocellar, ocellar and postvertical bristles are missing, only disorganised macrochaetae are present in this region. Medial portion of the frons is missing so a few lateral ridges of frons cuticle remain. One hour heat pulse of P{HS-en.G} at 100 hours AEL in oc1 individuals causes the reappearance of ocelli. Phenotypic series from the strongest to weakest oc allele: ocdb/ocdb > oc1/oc+ > ocγa1/oc+ > oc2/oc+ > oc1/oc1 > ocγa1/ocγa1 > oc2/oc1 > oc2/ocγa1.

Adult flies have defects in the ocellar region of the head capsule. oc1/ocγa1 transheterozygotes have slightly stronger defects. The ocelli and much of the adjacent cuticle is missing. The frons region lacks its typical ridged morphology and has ectopic bristles. oc1/ocγa1 transheterozygotes also variably lack parovaria. Clones in the head homozygous for oc1 show abnormal morphology only when located in the medial region (the ocellar and occipital regions and the frons).

female-sterile Eggs from oc1 homozygotes have defective chorions and abnormal β yolk spheres (Johnson and King, 1974). Sterility is due to the presence of In(1)oc, one breakpoint of which disrupts oc and the other of which interferes with amplification of the chorion-protein genes Cp36 and Cp38 (Spradling and Mahowald, 1981). oc1 in heterozygous combination with non-complementing lethal alleles survives and is female fertile.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

oc1 has visible | recessive phenotype, suppressible | partially by Hror\Otxhs.PA

oc1 has visible | recessive phenotype, suppressible | partially by Hsap\OTX1hs.PN

oc1 has visible | recessive phenotype, suppressible by Hsap\OTX2hs.PN

oc1 has visible | recessive phenotype, suppressible by Hsap\OTX1hs.PN

Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference

oc1 has ocellus phenotype, suppressible | partially by Hror\Otxhs.PA

oc1 has ocellar bristle phenotype, suppressible by Hsap\OTX1hs.PN

oc1 has ocellus phenotype, suppressible | partially by Hsap\OTX1hs.PN

oc1 has ocellus lens phenotype, suppressible by Hsap\OTX1hs.PN

oc1 has head bristle phenotype, suppressible by Hsap\OTX1hs.PN

oc1 has ocellus lens phenotype, suppressible by Hsap\OTX2hs.PN

oc1 has head bristle phenotype, suppressible by Hsap\OTX2hs.PN

NOT suppressed by
Statement
Reference

oc1 has ocellar bristle phenotype, non-suppressible by Hror\Otxhs.PA

oc1 has postvertical bristle phenotype, non-suppressible by Hror\Otxhs.PA

oc1 has phenotype, non-suppressible by su(Hw)2

Additional Comments
Genetic Interactions
Statement
Reference

Males expressing traScer\UAS.cFa under the control of Scer\GAL4103Y in an oc1 background do not show feminisation of walking behaviour; the number of start/stop bouts is not greater than in control males.

Xenogenetic Interactions
Statement
Reference

Hror\Otxhs.PA partially rescues the vertex defects of oc1 adults; rescue of ocellus lens structures but not of ocellar or postvertical bristles is seen. Hsap\OTX1hs.PN partially rescues the vertex defects of oc1 adults; 16.1% rescue of ocellus lens structures and some rescue of ocellar but not postvertical bristles is seen.

The phenotype is also complemented by Hsap\OTX1hs.PN or by Hsap\OTX2hs.PN; oc1 flies carrying either of these alleles have either ocellar lenses and/or associated ocellar pigments. The number of macrochaetae on the vertex of the head is also rescued towards wild-type in these flies.

Complementation and Rescue Data
Partially rescued by

oc1 is partially rescued by ochs.PR

oc1 is partially rescued by ochs.PR

Comments

The ocellus phenotype is partially rescued by ochs.PR, rescue being most effective when heat pulses are applied either 72-85 hours after egg laying (AEL) or 84-97 hours AEL, and being virtually ineffective when heat pulses are given at the end of the third larval instar stage.

Images (1)
Stocks (40)
Notes on Origin
Discoverer

Bedichek, 15th March 1930.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
References (28)